The effects of synergistic blend of organic acid or antibiotic growth promoter on performance and antimicrobial resistance of bacteria in grow–finish pigs

Ngoc, Tran Thi Bich; Oanh, Duong Thi; Pineda, Lane; Ayudhya, Suparlark; Groot, Nienke de; Han, Yanming

doi:10.1093/tas/txaa211

Cited by 7 publications

(5 citation statements)

References 31 publications

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“…Even Canibe et al [ 23 ] reported that 1.8% of formic acid supplements to the diet of growing pig showed tendency to increase the gain-to-feed (G:F) ratio. Similarly, Ngoc et al [ 24 ] stated that growing pigs diet supplemented with SGG had a positive impact on ADG and G:F. The probable reason for the improvement in BW, ADG, and ADFI of piglets that were born to SGG-Low and -High group sows in this study are mainly due to the antimicrobial activity of synergistic organic acid blend or due to the reduction of harmful microbial inhabitants, which helps to reduce the metabolic need of microbes and increase the availability of dietary energy and nutrients to host animals.…”

Section: Discussionmentioning

confidence: 91%

Sows fed with synergistic blend of short- and medium chain organic acid has a carryover effect on post-weaning growth rate

Sampath¹,

Park²,

Pineda³

et al. 2022

J Anim Sci Technol

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This study investigated the effect of a synergistic blend of free and buffered organic acid (FMP) on the performance of piglets born to sows supplemented with a blend of short- and medium-chain organic acids (SGG) during the late gestation and lactation period. A total of 150 multiparous sows (n = 50/treatment, Landrace × Yorkshire) were blocked (2.4 parity) and assigned to 1 of 3 dietary treatments: CON - corn-soybean meal-based basal diet, SGG-Low − CON+ 1.5 kg/ton SGG, and SGG-High − CON + 3kg/ton SGG. During weaning, 600 piglets (6.72 ± 0.5kg) which weaned from sows supplemented with 3 levels of SGG were allocated to 2 weaner diets (Control and FMP - 3kg/ton) following 3 × 2 factorial arrangement. Supplemental effects on performance were measured at d0–d21 and d 21–42, and the entire period. Pigs fed with FMP and born to sows supplemented with SGG-High gained more weight and ate more ( p < 0.05) compared with those in the CON group in both phases, and with SGG-Low in the second phase. Over the entire post-weaning period, piglets born to sows supplemented with SGG-Low and SGG-High had a higher average daily gain (ADG) and body weight (BW) ( p < 0.05). Regardless of sow treatment, pigs fed with an FMP diet had higher ADG ( p < 0.001), BW ( p = 0.045), and a lower feed conversion ratio ( p = 0.033). Also, feeding FMP diets reduced the fecal Escherichia coli and Clostridium perfringens counts at d42. The current study indicates that sows fed SGG supplement had a positive carry-over effect on the post-weaning growth rate, and FMP supplement enhances the growth performance and reduced the number of C. perfringens and E. coli . Thus, the application of 3 kg/ton of SGG in sows’ diet and subsequent feeding of piglets with FMP would be an effective strategy to improve growth rate and reduce pathogenic bacteria in post-weaned piglets.

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Section: Discussionmentioning

confidence: 91%

Sows fed with synergistic blend of short- and medium chain organic acid has a carryover effect on post-weaning growth rate

Sampath¹,

Park²,

Pineda³

et al. 2022

J Anim Sci Technol

Self Cite

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“…Similarly, dietary supplementation of organic acids (fumaric acid, citric acid, malic acid, and MCFAs) in growing pig diet improved the performance by diminishing gastrointestinal pH leading to alteration of the intestinal microbiota (Upadhaya et al, 2014a). Besides, a previous study by Ngoc et al (2020) indicated that the Selacid GG (ORAC) supplementation significantly improved the final BW (3.6%), ADG (5.3%), and gain: Feed (8.1%) of pigs in the period 25-100kg. The positive influences of probiotics and organic acids on animal performance could be due to nutrient competition, antimicrobial substances production, intestinal adhesion or competitive inhibition of pathogenic bacteria (Steer et al, 2000;Zimmermann et al, 2016).…”

Section: Advances In Animal and Veterinary Sciencesmentioning

confidence: 94%

“…The organic acids (ORAC) used in our study was produced by a commercial company (Selacid GG, Trouw Nutrition, Netherlands). This product consisted of short chain fatty acids, buffered organic acid and a combination of mediumchain fatty acids (Ngoc et al, 2020).…”

Section: Source Of Probiotics and Organic Acidsmentioning

confidence: 99%

Effects of Probiotics and Organic Acids and Their Mixture on Nutrient Digestibility, Growth Performance and Fecal Gas Emission in Grower-Finisher Pigs

Ngoc¹,

Huyen²,

Cong³

et al. 2021

AAVS

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This study was carried out to evaluate the effects of dietary supplementation of probiotics (PROB), organic acids (ORAC), and their mix (PROR) on growth performance, nutrient digestibility, and fecal noxious gas concentration in grower-finisher pigs. Twenty-four barrows [(Pietrain × Duroc) × (Landrace × Yorkshire)], with an average initial body weight of 26 ± 0.77 kg (around 75 days old), were equally divided into four dietary groups, 6 replicates each group. The animals were housed individually in metabolism cages. The four experimental diets consisted of a basal diet (CONT), PROB diet (CONT + 0.2% PROB), ORAC diet (CONT + 0.2% ORAC), and PROR diet (CONT + 0.2% PROB + 0.2% ORAC) for 60 days including 2 periods (25-45 kg and 45-65 kg). In comparison to the CONT group, dietary supplementation of PROB or ORAC or PROR increased ADG and decreased FCR (P < 0.0001), with the higher ADG and lower FCR for PROR group during the entire experimental period. Pigs fed PROB or ORAC or PROR diets led to higher (P < 0.05) apparent total tract digestibility of protein, organic matter, neutral detergent fiber, and phosphorus than those fed CONT diet. A significant decrease in ammonia (NH 3 ) and hydrogen sulfide (H 2 S) concentrations were observed in diets with PROB or ORAC or PROR, with lower values for PROR diet. In conclusion, in grower-finisher pigs, dietary supplementation of either PROB or ORAC as a single product or their combination had improvements in performance parameters, nutrient digestibility, and fecal NH 3 and H 2 S emissions compared with CONT diet. There were no differences in performance parameters between the use of the single product and the combination. In general, a diet containing a combination of PROB and ORAC had larger effects on parameters observed than a diet containing either PROB or ORAC.

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“…Comparable to other antibiotics, organic acids show a broad spectrum of antimicrobial activity [ 112 ] which can contribute to the expression of the antibiotic resistance gene (ARG) and mobile genetic element. Interestingly, a study in pigs did not find any associated genes encoding resistance to tetracycline, streptomycin, or sulfonamide when feed with a blend of propionic, formic and acetic acids, cinnamaldehyde, and a permeabilizing complex was used [ 113 ]. Another study showed that, compared to feed containing the antibiotic enrofloxacin, acidifier-based feeds (formic, propionic, and acetic acids) did not change the total number of cecal E. coli .…”

Section: Alternatives To Antibiotics As Growth Promotersmentioning

confidence: 99%

Insights in the Development and Uses of Alternatives to Antibiotic Growth Promoters in Poultry and Swine Production

2022

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The overuse and misuse of antibiotics has contributed to the rise and spread of multidrug-resistant bacteria. To address this global public health threat, many countries have restricted the use of antibiotics as growth promoters and promoted the development of alternatives to antibiotics in human and veterinary medicine and animal farming. In food-animal production, acidifiers, bacteriophages, enzymes, phytochemicals, probiotics, prebiotics, and antimicrobial peptides have shown hallmarks as alternatives to antibiotics. This review reports the current state of these alternatives as growth-promoting factors for poultry and swine production and describes their mode of action. Recent findings on their usefulness and the factors that presently hinder their broader use in animal food production are identified by SWOT (strength, weakness, opportunity, and threat) analysis. The potential for resistance development as well as co- and cross-resistance with currently used antibiotics is also discussed. Using predetermined keywords, we searched specialized databases including Scopus, Web of Science, and Google Scholar. Antibiotic resistance cannot be stopped, but its spreading can certainly be hindered or delayed with the development of more alternatives with innovative modes of action and a wise and careful use of antimicrobials in a One Health approach.

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The effects of synergistic blend of organic acid or antibiotic growth promoter on performance and antimicrobial resistance of bacteria in grow–finish pigs

Cited by 7 publications

References 31 publications

Sows fed with synergistic blend of short- and medium chain organic acid has a carryover effect on post-weaning growth rate

Sows fed with synergistic blend of short- and medium chain organic acid has a carryover effect on post-weaning growth rate

Effects of Probiotics and Organic Acids and Their Mixture on Nutrient Digestibility, Growth Performance and Fecal Gas Emission in Grower-Finisher Pigs

Insights in the Development and Uses of Alternatives to Antibiotic Growth Promoters in Poultry and Swine Production

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