This study was carried out to evaluate the effect of Selacid Green Growth (GG) or antibiotic growth promoter (AGP) on the performance and economics of grow-finish (GF) pigs. The Selacid GG is a blend of short chain fatty acids (formic acid, acetic acid, lactic acid, propionic acid, citric acid, sorbic acid), buffered organic acid (ammonium formate), and a combination of medium chain fatty acids (C8, C10, and C12). A total of 312 grower pigs (Yorkshire × Landrace × Duroc) with an initial body weight (BW) of 26.5±0.92 kg was used in a 90-day feeding trial. The pigs were allocated randomly to three treatments consisting of 8 replicate pens with 13 pigs each. The treatments tested included a (1) Negative Control (control): basal diet without Colistin and Selacid GG, (2) Positive Control (AGP): basal diet with Colistin (20 g/ton), (3) Feed additive (Selacid GG): basal diet with Selacid GG (2 kg/ton). The results showed that over the entire period of the experiment, the dietary supplementation of Selacid GG elicited a similar effect as AGP on feed cost and on all growth parameters measured (P>0.05). In relation to the control group, Selacid GG significantly improved the final BW (+3.4 kg or 3.6%), average daily gain (ADG) (+39 g/pig or 5.3%) and Gain:Feed (+30 g or 8.1%) of pigs (P<0.05). In addition, the feeding of Selacid GG reduced feed cost (−0.078 USD) per kilogram BW gain. The average daily feed intake was not affected by the dietary treatments (P>0.05). E. coli was prevalent in 46 out of 48 fecal samples tested. All E. coli isolates were resistant to Colistin, Amox-Colistin, Ciprofloxacin and Enrofloxacin. The number of E. coli isolates resistant to Amoxicillin/clavulanic, Cefotaxime, Ceftiofur and Norfloxacin was significantly reduced; whereas the inhibitory zones of Amocxillin/clavulanic acid were increased; and the susceptibility of E. coli to Amoxcillin/clavulanic, Cefotaxime, Ceftiofur, Ciprofloxacin, Nofloxacin and Flumequin was increased when Selacid GG was added in the feeds (P<0.05). The findings of the study suggest that Selacid GG is a cost-effective product with the same efficacy as AGP in promoting the growth and economic performance of GF pigs. The product is safe and can be added in the diet of GF pigs without developing resistance to selected antibiotics.