The effects of temperature on the spherical crystallization of salicylic acid

Kawashima, Yasunaru; Okumura, Motonari; Takenaka, Hideo

doi:10.1016/0032-5910(84)85018-4

Cited by 53 publications

(36 citation statements)

References 10 publications

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“…[1][2][3] Spherical crystallization is a nonconventional particle-size enlargement technique that involves crystallization and agglomeration using bridging liquid. 4,5 Different methods have been reported to achieve supersaturation during spherical crystallization. [6][7][8][9][10] Spherical crystallization has been used mainly to obtain directly compressible agglomerates of a single, water-insoluble large-dose drug, and rarely in combination with a diluent.…”

Section: Introductionmentioning

confidence: 99%

Crystallo-co-agglomeration: A novel technique to obtain ibuprofen-paracetamol agglomerates

et al. 2004

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The purpose of this research was to obtain directly compressible agglomerates of ibuprofen-paracetamol containing a desired ratio of drugs using a crystallo-co-agglomeration technique. Crystallo-co-agglomeration is an extension of the spherical crystallization technique, which enables simultaneous crystallization and agglomeration of 2 or more drugs or crystallization of a drug and its simultaneous agglomeration with another drug or excipient. Dichloromethane (DCM)-water system containing polyethylene glycol (PEG) 6000, polyvinyl pyrollidone, and ethylcellulose was used as the crystallization system. DCM acted as a good solvent for ibuprofen and bridging liquid for agglomeration. The process was performed at pH 5, considering the low solubility of ibuprofen and the stability of paracetamol. Loss of paracetamol was reduced by maintaining a low process temperature and by the addition of dextrose as a solubility suppressant. The agglomerates were characterized by differential scanning calorimetry, powder x-ray diffraction (PXRD), and scanning electron microscopy and were evaluated for tableting properties. The spherical agglomerates contained an ibuprofen-paracetamol ratio in the range of 1.23 to 1.36. Micromeritic, mechanical, and compressional properties of the agglomerates were affected by incorporated polymer. The PXRD data showed reduction in intensities owing to dilution and reduced crystallinity. Thermal data showed interaction between components at higher temperature. Ethylcellulose imparted mechanical strength to the agglomerates as well as compacts. The agglomerates containing PEG have better compressibility but drug release in the initial stages was affected owing to asperity melting, yielding harder compacts. The agglomeration and properties of agglomerates were influenced by the nature of polymer.

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Section: Introductionmentioning

confidence: 99%

Crystallo-co-agglomeration: A novel technique to obtain ibuprofen-paracetamol agglomerates

et al. 2004

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“…The crystalline asprin sample was structurally and spectrophotometrically examined by both of X-ray diffraction as shown in Fig.1 and infrared spectroscopy respectively and well The analysis of SE-micrograph recorded for crystalline asprin indicated that the grain size ranged in between 170-200 nm and no in-homogeneities observed on the grain boundaries or in between grain which refer to the quality of synthesis applying solution route [9][10][11] .The balck arrows in Fig.2 display moderate to large size gains while red arrows are foe small size gains…”

Section: Results and Discusionsmentioning

confidence: 99%

“…The synthesis of asprin involves the reaction of salicylic acid and acetic anhydride in the presence of phosphoric acid, H 3 PO 4 as catalyst [9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

Soft Synthesis and Nano -Structural Features of Highly Crystalline Asprin An AFM-Investigations

Sekkina¹,

M.Elsabawya²,

El‐Maghraby³

2013

Orient. J. Chem

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The present investigations introduce new trend of applying AFM-microscopy to visualize a real 3D-imaging of sample's surface topography. High resolution AFM-investigations indicated that crystalline asprin has regular arrays of atomic arrangement with no violation in the bulk of asprin .TM deflection AFM-gave us good approximation to the diffusion of grain throughout the surface topology of investigated asprin . The AFM-deflection centers imaging indicated that the numbers of grains distribute in circular arrangements on the surface and material bulk .3D-visualized imaging introduce precise determination of exposure surface area interacting with dissolving agent.

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“…So some of the emulsion droplets were gathered in the process of solidification. Interfacial tension effects and capillary action showed that the bridging agent (wetting agent) plays a role in blocking drug crystallization (42). Since bridging agent and poor solvent are immiscible with preferential wetting solution crystallization, so crystalline deposit precipitates immediately under agitation.…”

Section: Droplet Size Of Solid Self-microemulsionmentioning

confidence: 99%

Preparation and In Vitro/In Vivo Evaluation of Puerarin Solid Self-Microemulsifying Drug Delivery System by Spherical Crystallization Technique

Cheng

et al. 2015

AAPS PharmSciTech

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Abstract. The aim of this work was to establish a method for preparing stable and controllable solid selfmicroemulsifying drug delivery system (S-SMEDDS) by spherical crystallization technique, which was explored for promoting the dissolution, oral bioavailability, and process efficiency. Solubility test, preparation of liquid self-microemulsifying drug delivery system (L-SMEDDS), and the obtained ternary phase diagrams test have been performed to screen and optimize the composition of LSMEDDS. The optimized formulation was used to prepare puerarin solid self-microemulsifying drug delivery system (Pue-SSMEDDS) by spherical crystallization technique. Droplet size and morphological analysis of the optimal Pue-SSMEDDS were determined to evaluate the final formulation. And the Pue-SSMEDDS was also assessed by flowability study, angle of repose, Carr's index, and flow velocity. Furthermore, the vitro dissolution and pharmacokinetic profile in vivo were analyzed. The study in vitro showed the Pue-SSMEDDS could disperse in the dispersion medium within 60 s and was spherical with the particle size of 19.66 nm and zeta potential of −28.3 mV. It could keep stable at low temperature and seal condition for 3 months. In vivo pharmacokinetic experiments of rats, the mean plasma concentration of selfmicroemulsion group was much higher than that of conventional tablets and could play a long-lasting efficacy, while there was no significant difference between the LSMEDDS and S-SMEDDS. The results suggested the potential of S-SMEDDS could improve the oral bioavailability of poorly water-soluble drug, such as puerarin.

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The effects of temperature on the spherical crystallization of salicylic acid

Cited by 53 publications

References 10 publications

Crystallo-co-agglomeration: A novel technique to obtain ibuprofen-paracetamol agglomerates

Crystallo-co-agglomeration: A novel technique to obtain ibuprofen-paracetamol agglomerates

Soft Synthesis and Nano -Structural Features of Highly Crystalline Asprin An AFM-Investigations

Preparation and In Vitro/In Vivo Evaluation of Puerarin Solid Self-Microemulsifying Drug Delivery System by Spherical Crystallization Technique

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