The effects of the interthalamic adhesion position on cerebrospinal fluid dynamics in the cerebral ventricles

Tan, Kristy; Bilston, Lynne E.

doi:10.1016/j.jbiomech.2009.10.002

Cited by 27 publications

(20 citation statements)

References 17 publications

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“…Wall effects of pulsatile CSF flow in the ventricular space have received little attention so far. Biological studies in animal or in vitro models have mostly focused on flow and WSS induced by the cilia alone [4,26], whereas macroscopic flows have been approached predominantly from a neurosurgical [27,29,30], radiological [31][32][33] or biomedical [15][16][17][18]20] point of view, mostly without interest in WSS or near-wall dynamics. In point of fact, WSS estimates from radiological studies are limited by the near-wall resolution, whereas numerical investigations have been limited by underlying model assumptions, including simplified geometries, steady flows, neglected wall motion, choroid plexus pulsations or cilia action.…”

Section: Discussionmentioning

confidence: 99%

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Flow induced by ependymal cilia dominates near-wall cerebrospinal fluid dynamics in the lateral ventricles

Siyahhan

Knobloch

Zélicourt

et al. 2014

J. R. Soc. Interface.

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While there is growing experimental evidence that cerebrospinal fluid (CSF) flow induced by the beating of ependymal cilia is an important factor for neuronal guidance, the respective contribution of vascular pulsation-driven macroscale oscillatory CSF flow remains unclear. This work uses computational fluid dynamics to elucidate the interplay between macroscale and cilia-induced CSF flows and their relative impact on near-wall dynamics. Physiological macroscale CSF dynamics are simulated in the ventricular space using subject-specific anatomy, wall motion and choroid plexus pulsations derived from magnetic resonance imaging. Near-wall flow is quantified in two subdomains selected from the right lateral ventricle, for which dynamic boundary conditions are extracted from the macroscale simulations. When cilia are neglected, CSF pulsation leads to periodic flow reversals along the ventricular surface, resulting in close to zero time-averaged force on the ventricle wall. The cilia promote more aligned wall shear stresses that are on average two orders of magnitude larger compared with those produced by macroscopic pulsatile flow. These findings indicate that CSF flow-mediated neuronal guidance is likely to be dominated by the action of the ependymal cilia in the lateral ventricles, whereas CSF dynamics in the centre regions of the ventricles is driven predominantly by wall motion and choroid plexus pulsation.

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Section: Discussionmentioning

confidence: 99%

“…These are known to produce pulsatile CSF flow with velocities several orders of magnitude larger than those generated by the cilia [15][16][17][18][19][20]. Vice versa, none of the investigations of large-scale CSF dynamics has taken into account the effect of cilia motion.…”

Section: Introductionmentioning

confidence: 99%

Flow induced by ependymal cilia dominates near-wall cerebrospinal fluid dynamics in the lateral ventricles

Siyahhan

Knobloch

Zélicourt

et al. 2014

J. R. Soc. Interface.

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“…A recent computational study on CSF dynamics in the third ventricle demonstrated that pressure in the third ventricle is higher when the IA is located close to the cerebral aqueduct [35]. Intriguingly, all patients with this peculiar form of DMJ abnormality also had moderate enlargement of the lateral ventricles.…”

Section: Type B Dmj Patternmentioning

confidence: 93%

Expanding the spectrum of congenital anomalies of the diencephalic–mesencephalic junction

et al. 2015

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“…In the work of Cheng et al (2010), it is stated that the structure of the ventricles of the brain play a vital role in the flow of cerebrospinal fluid (CSF), in that the CSF passes in a pulsatile manner that is related to the pulsation of the heart. The volume of these ventricles is vital in indicating the amount of CSF that is located within them (Shoshani et al, 2006) and understanding the amount of CSF contained is important as an indicator of the physiology of the brain in the species concerned.…”

Section: Introductionmentioning

confidence: 99%

Volumetric Analysis of the African Elephant Ventricular System

Maskeo

Spocter

Haagensen

et al. 2011

The Anatomical Record

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This study used magnetic resonance imaging (MRI) to determine the volume of the ventricular system in the brain of three adult male African elephants (Loxodonta africana). The ventricular system of the elephant has a volume of $240 mL, an order of magnitude larger than that seen in the adult human. Despite this large size, allometric analysis indicates that the volume of the ventricles in the elephant is what one would expect for a mammal with an $5 kg brain. Interestingly, our comparison with other mammals revealed that primates appear to have small relative ventricular volumes, and that megachiropterans and microchiropterans follow different scaling rules when comparing ventricular volume to brain mass indicating separate phylogenetic histories. The current study provides context for one aspect of the elephant brain in the broader picture of mammalian brain evolution.

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The effects of the interthalamic adhesion position on cerebrospinal fluid dynamics in the cerebral ventricles

Cited by 27 publications

References 17 publications

Flow induced by ependymal cilia dominates near-wall cerebrospinal fluid dynamics in the lateral ventricles

Flow induced by ependymal cilia dominates near-wall cerebrospinal fluid dynamics in the lateral ventricles

Expanding the spectrum of congenital anomalies of the diencephalic–mesencephalic junction

Volumetric Analysis of the African Elephant Ventricular System

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