The effects of the surgical removal of subcutaneous adipose tissue on energy expenditure and adipocytokine concentrations in obese women

Busetto, Luca; Bassetto, Franco; Zocchi, Michele L.; Zuliani, Francesca; Nolli, Maria Luisa; Pigozzo, Sabrina; Coin, Alessandra; Mazza, M.; Sergi, Giuseppe; Mazzoleni, Francesco; Enzi, Giuliano

doi:10.1016/j.numecd.2006.09.009

Cited by 54 publications

(47 citation statements)

References 36 publications

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“…A reduction of serum leptin concentrations was also observed in obese women after surgical removal of subcutaneous adipose tissue [12,13] . Assuming that a high serum leptin concentration is responsible for the downregulation of lipogenic enzyme gene expression in WAT of old rats, the decrease in plasma leptin concentration, due to surgical removal of abdominal (perirenal and epididymal) fat pads, should lead to an increase of lipogenic enzyme activities.…”

Section: Introductionmentioning

confidence: 79%

Surgical Removal of Perirenal and Epididymal Adipose Tissue Decreases Serum Leptin Concentration and Increases Lipogenic Enzyme Activities in Remnant Adipose Tissue of Old Rats

Nogalska

Stelmańska²,

Śledziński³

et al. 2008

Gerontology

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Background: The rate of lipogenesis and gene expression of lipogenic enzymes in white adipose tissue (WAT) of rats decreases with age. Previously, we showed the inverse relationship between serum leptin concentration and lipogenic enzymes activities in WAT of ageing rats. Based on those results, we postulated that leptin could play some role in the downregulation of lipogenic enzyme genes expression in WAT of old rats. Objective: To further test this hypothesis, in the present paper we examined the effect of surgical removal of perirenal and epididymal WAT on serum leptin concentration and lipogenic enzymes activities in remnant adipose tissue of old rats. Methods: One-year-old rats, which display a high serum leptin concentration and low lipogenic enzyme activities in WAT, were subjected to surgical removal of the perirenal and epididymal WAT. Two months after the surgery, the serum leptin concentration and lipogenic enzyme activities in remnant WAT were compared to the serum leptin concentration and lipogenic enzyme activities measured in adipose tissue collected during the surgery. Results: WAT removal resulted in an approximately 6-fold decrease of serum leptin concentration and about a 2-fold increase of lipogenic enzyme activities in remnant adipose tissue. Conclusions: These results indicate that interventions designed to reduce abdominal adipose tissue mass can change the lipogenic activity of remnant adipose tissue. Additionally, leptin could be one of the factors contributing to the downregulation of the genes expression of lipogenic enzymes during ageing in rats.

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Section: Introductionmentioning

confidence: 79%

Surgical Removal of Perirenal and Epididymal Adipose Tissue Decreases Serum Leptin Concentration and Increases Lipogenic Enzyme Activities in Remnant Adipose Tissue of Old Rats

Nogalska

Stelmańska²,

Śledziński³

et al. 2008

Gerontology

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“…It was suggested that a decrease in energy expenditure may also contribute to the compensatory increase in fat mass after liposuction (Benatti et al, 2012). Lower concentration of circulating leptin and changes in the hypothalamic neuropeptide gene expression favors the post-lipectomy decrease in energy expenditure (Busetto et al, 2008;Joly-Amado et al, 2014). Thus, it was the decrease in the energy expenditure which likely contributed, at least in part, to the accelerated body weight gain and increase in standard growth rate observed in our experimental model.…”

Section: Discussionmentioning

confidence: 70%

Up-regulation of orexigenic and down-regulation of anorexigenic neuropeptide gene expression in rat hypothalamus after partial lipectomy

2015

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AgRP POMC CART Leptin Standard growth rate Lipectomy Abbreviations: AgRP, agouti related protein CART, cocaine-amphetamineregulated transcript peptide a-MSH, a-melanocyte stimulating hormone MC4R, melanocortin receptors NPY, neuropeptide Y POMC, pro-opiomelanocortin WAT, white adipose tissue a b s t r a c t Leptin down-regulates orexigenic and up-regulates anorexigenic neuropeptide gene expression in hypothalamus. Surgical removal of adipose tissue leads to decrease in circulating leptin concentrations in rats.In the present study, we tested: (a) regulation of neuropeptide gene expression in hypothalamus, (b) food intake, and (c) standard growth rate after removal of adipose tissue in rats. Partial lipectomy caused an approximately 10-fold reduction of subcutaneous, retroperitoneal and epididymal adipose tissue weight (at the end of experiments adipose tissue weight was 1.5 AE 0.9 in lipectomy and 15 AE 3.9 g in control rats; statistically significant). Compared to control rats, the animals subjected to lipectomy presented increased food intake, standard growth rate, and decreased serum leptin concentrations (2.6 AE 0.8 vs. 3.7 AE 1.2 ng/mL in the controls, statistically significant). These changes were associated with approximately twofold increase in neuropeptide Y, threefold increase in agouti-related peptide (orexigenic neuropeptides) and about 50% decrease in proopiomelanocortin and cocaine-amphetamine-regulated transcript peptide (anorexigenic neuropeptides) mRNA levels in the hypothalamus. These results suggest that partial lipectomy, leading to a decrease in circulating leptin concentrations, may exert an effect on hypothalamic orexigenic and anorexigenic neuropeptide gene expression, and consequently modulate food intake and standard growth rate in rats.

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“…Otherwise, a stable nutritional biochemical pattern was documented throughout the observation period (Table 2). Table 3 summarizes the findings from the literature concerning the impact of liposuction and abdominoplasty on metabolic variables [2][3][4][5][6][7][8][9][10][11][12].…”

Section: Resultsmentioning

confidence: 99%

“…Alleviation of systemic inflammation and insulin resistance has been reported by some researches, whereas in certain studies, the improvement of plasma lipids has been confirmed [4][5][6][7][8]. In contrast, no changes in insulin action and cardiovascular risk factors have been noticed by other studies [9,10].…”

Section: Introductionmentioning

confidence: 98%

C-Reactive Protein Decrease After Postbariatric Abdominoplasty

Junior¹,

Modolin²,

Faintuch

et al. 2011

Inflammation

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In a prospective study, indices of glucose homeostasis, lipid profile, and systemic inflammation were monitored after an aesthetic abdominoplasty, aiming to scrutinize the possible metabolic benefits for abdominal fat removal. Premenopausal females with substantial weight loss (N=40) undergoing circumferential abdominoplasty (index group, n=20) or augmentation mammoplasty with mastopexy (controls, n=20) were recruited. All of them originally underwent Roux-en-Y gastric bypass. Variables included BMI, white blood cell count, C-reactive protein, hemoglobin, total cholesterol and fractions, triglycerides, glucose, and HbA1c. Follow-up reached 20.3 ± 13.6 months for index cases and 29.5 ± 17.4 months for controls. The metabolic and inflammatory indices improved after the bariatric surgery. Subsequent monitoring indicated a stable body weight and biochemical profile in both groups. The exceptions were HDL cholesterol and C-reactive protein, which respectively increased and diminished after the abdominoplasty, consistent with an inflammatory and metabolic advantage for this operation. This is the first long-term study in a weight-stable population to point out such a pattern after abdominoplasty.

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The effects of the surgical removal of subcutaneous adipose tissue on energy expenditure and adipocytokine concentrations in obese women

Cited by 54 publications

References 36 publications

Surgical Removal of Perirenal and Epididymal Adipose Tissue Decreases Serum Leptin Concentration and Increases Lipogenic Enzyme Activities in Remnant Adipose Tissue of Old Rats

Surgical Removal of Perirenal and Epididymal Adipose Tissue Decreases Serum Leptin Concentration and Increases Lipogenic Enzyme Activities in Remnant Adipose Tissue of Old Rats

Up-regulation of orexigenic and down-regulation of anorexigenic neuropeptide gene expression in rat hypothalamus after partial lipectomy

C-Reactive Protein Decrease After Postbariatric Abdominoplasty

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