The Effects of Titanium Implant Surface Topography on Osseointegration: Literature Review

Kumar, Preeti Satheesh; KS, Satheesh Kumar; Grandhi, Vyoma Venkatesh; Gupta, Vrinda

doi:10.2196/13237

Cited by 22 publications

(15 citation statements)

References 89 publications

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“…The results indicated that compared with other coatings, the UG-MH coating was more conducive to osseointegration because of its moderate surface roughness (1.83 μm). Increased surface topography positively affected osteoblast activities . Our study also revealed an increase in the proliferation rate of osteoblasts and average osteoblast spreading area, with increased surface topography modifications on titanium implants.…”

Section: Resultssupporting

confidence: 60%

“…Increased surface topography positively affected osteoblast activities. 47 Our study also revealed an increase in the proliferation rate of osteoblasts and average osteoblast spreading area, with increased surface topography modifications on titanium implants. Along with its microscale and nanoscale hierarchical structure, the UG-MH coating enabled greater bone-to-implant contact area than the other coatings and adhesion sites with osteoblasts and provided a microenvironment that facilitated the adhesion and ingrowth of osteoblasts that was superior to those of the other coatings.…”

Section: Xps Analysis and Coating Phase Compositionssupporting

confidence: 61%

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A Novel Cytocompatibility Strengthening Strategy of Ultrafine-Grained Pure Titanium

Xu¹,

Li²,

Xu³

et al. 2019

ACS Appl. Mater. Interfaces

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Ultrafine-grained pure (UFG) titanium processed by equal channel angular pressing possesses mechanical properties comparable to those of Ti-6Al-4V and features more favorable friction resistance, biocompatibility, and corrosion resistance than does commercially pure (CP) titanium. Nevertheless, UFG titanium is still a bio-inert material with a lack of bone-inducing ability. Here, TiO2-hydroxyapatite (TiO2-HA) coatings were fabricated on CP titanium and UFG titanium through combining micro-arc oxidation and hydrothermal treatment together to improve their cytocompatibility. The results indicate that, compared with conventional coatings that use CP titanium as the substrate, such coatings formed on the UFG titanium possess additional hydrophilicity and in vitro cytocompatibility. The fantastic hierarchical structure of the UFG TiO2-HA coating (UG-MH coating), including microscale and nanoscale pores and short column-shaped and sheet-shaped HA grains with varying geometric shapes, excellent hydrophilicity, and high polar force, enhances the mutual effects between the osteoblasts and titanium implant since it provides an adequate microenvironment for the ingrowth of osteoblasts, inducing osteoblast adhesion, proliferation, and differentiation. The UG-MH coating has a synergistic effect due to its fantastic hydrophilic hierarchical structure and high polar force on the up-regulated expression of cytoskeletal actin proteins as well as osteocalcin, protein kinase C (PKC), nuclear factor of activated T-cells (NFAT), and Wnt5, enabling osteoblasts to differentiate via the Wnt calcium-dependent signaling pathway. This study highlights the idea that the modified UFG titanium will be more suitable than CP titanium in dental and orthopedic applications.

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Section: Resultssupporting

confidence: 60%

Section: Xps Analysis and Coating Phase Compositionssupporting

confidence: 61%

A Novel Cytocompatibility Strengthening Strategy of Ultrafine-Grained Pure Titanium

Xu¹,

Li²,

Xu³

et al. 2019

ACS Appl. Mater. Interfaces

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“…In orthopedic applications, titanium (Ti) has been and still is the material of choice due to properties such as high strength and corrosion resistance (Hanawa, 2019). To improve the bioactivity of Ti-based materials, several strategies are used, including physical treatments to modify the topography (Wennerberg and Albrektsson, 2009;Nikkhah et al, 2012;Kumar et al, 2019) or chemical treatments to modify the bioactivity (Kokubo and Yamaguchi, 2015;Muderrisoglu et al, 2018;Devgan and Sidhu, 2019) all aiming to optimize the interaction with osteoblastic cells.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Intracellular Calcium Ion Mobilization by Moderately but Not Highly Positive Material Surface Charges

Gruening

Neuber

Nestler

et al. 2020

Front. Bioeng. Biotechnol.

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Electrostatic forces at the cell interface affect the nature of cell adhesion and function; but there is still limited knowledge about the impact of positive or negative surface charges on cell-material interactions in regenerative medicine. Titanium surfaces with a variety of zeta potentials between −90 mV and +50 mV were generated by functionalizing them with amino polymers, extracellular matrix proteins/peptide motifs and polyelectrolyte multilayers. A significant enhancement of intracellular calcium mobilization was achieved on surfaces with a moderately positive (+1 to +10 mV) compared with a negative zeta potential (−90 to −3 mV). Dramatic losses of cell activity (membrane integrity, viability, proliferation, calcium mobilization) were observed on surfaces with a highly positive zeta potential (+50 mV). This systematic study indicates that cells do not prefer positive charges in general, merely moderately positive ones. The cell behavior of MG-63s could be correlated with the materials' zeta potential; but not with water contact angle or surface free energy. Our findings present new insights and provide an essential knowledge for future applications in dental and orthopedic surgery.

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“…However, at these low concentrations, apart from increasing fibroblast proliferation, there was also a significant increase in interleukin 6, osteoprotegerin, and sclerostin, all of which play a role in bone formation and prevent bone resorption [34]. This event can be explained by HF affecting the stage of cell differentiation, which is more likely to affect osteoprogenitor cells or undifferentiated osteoblasts [35][36][37].…”

Section: Discussionmentioning

confidence: 99%

Surface Properties and Biocompatibility of Anodized Titanium with a Potential Pretreatment for Biomedical Applications

Huang

Lan

et al. 2021

Metals

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The effects of anodized titanium (Ti) with a potential hydrogen fluoride (HF) acid pretreatment through cathodization on the formation of nano-porous Ti dioxide (TiO2) layer were characterized using field-emission scanning electron microscopy, grazing incidence X-ray diffractometer, and contact angle goniometer. The biocompatibility was determined by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) test. Analytical results found that a well-aligned nano-porous structure was formed on the anodized Ti surface with HF pretreatment concentration above 0.5%. Microstructure of the nano-porous Ti dioxide surface generated by anodization with HF pretreatment was composed of anatase and rutile phases, while the anodized Ti sample with HF pretreatment concentration of 0.5% presented excellent hydrophilicity surface. An in-vitro biocompatibility also indicated that osteoblast cells grown on the surface of the anodized Ti sample with HF pretreatment increased with the increase of culture time. The filopodia of osteoblast cells not only adhered flat, but also tightly grabbed the nano-porous structure for promoting cell adhesion and proliferation. Therefore, the anodized Ti with HF pretreatment can form a functionalized surface with great biocompatibility for biomedical applications, particularly for dental implants.

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The Effects of Titanium Implant Surface Topography on Osseointegration: Literature Review

Cited by 22 publications

References 89 publications

A Novel Cytocompatibility Strengthening Strategy of Ultrafine-Grained Pure Titanium

A Novel Cytocompatibility Strengthening Strategy of Ultrafine-Grained Pure Titanium

Enhancement of Intracellular Calcium Ion Mobilization by Moderately but Not Highly Positive Material Surface Charges

Surface Properties and Biocompatibility of Anodized Titanium with a Potential Pretreatment for Biomedical Applications

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