The effects of training intensity on muscle buffer capacity in females

Edge, Johann; Bishop, David; Goodman, Carmél

doi:10.1007/s00421-005-0068-6

Cited by 146 publications

(155 citation statements)

References 40 publications

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“…5,22,27,31,42,43,47 Alternatively, there could be changes in the buffering capacity of the muscle to maintain pH such that a pH of 5 is buffered slower than under nonfatigue conditions. 13,33 However, the current study was unable to detect changes in lactate, phosphate, creatinine kinase, or to detect infiltration of neutrophils in the muscle, suggesting that metabolic changes in the muscle associated with damage are unlikely to contribute to the enhanced nociceptive response to pH. Changes in blood lactate clearly occur during a fatiguing exercise bout, 12,16,34,37 and these lactate changes can last up to 15 minutes after a high-intensity exercise bout.…”

Section: Peripheral Mechanisms For Enhanced Nociception After Fatiguecontrasting

confidence: 55%

Muscle Fatigue Increases the Probability of Developing Hyperalgesia in Mice

Yokoyama

Lisi

Moore

et al. 2007

The Journal of Pain

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Chronic muscle pain is a major clinical problem that is often associated with fatigue. Conversely, chronic fatigue conditions are commonly associated with muscle pain. We tested the hypothesis that muscle fatigue enhances hyperalgesia associated with injection of acidic saline into muscle. We evaluated mechanical sensitivity of the paw (von Frey) in mice after 2 intramuscular injections of saline (20 µL; pH 4, pH 5, pH 6, pH 7.2) in a fatigue and a control group. To induce fatigue, mice were run for 2 h/day for 2 days prior to the first injection and 2 h/day for 2 days prior to the second injection. Muscle lactate, pCO 2 , pO 2 , creatinine kinase, phosphate, and histology were examined after the fatigue task and compared to a control group. Grip force was significantly decreased after 2 h of running indicating fatigue. The fatigue task did not induce muscle damage as there was no difference in muscle lactate, pCO 2 , pO 2 , creatinine kinase, phosphate, or histology. The fatigue task altered the dose-response relationship to intramuscular acidic saline injections. Mechanical hyperalgesia was observed in both fatigue and control groups after intramuscular injection of pH 4.0, but only the fatigue group after injection of pH 5. Neither the fatigue nor the control group developed hyperalgesia in response to intramuscular injection of pH 6 or pH 7.2. In conclusion, fatigue modified the susceptibility of mice to acid injection of pH 5.0 to result in mechanical hyperalgesia after 2 injections of pH 5.0. The fatigue task did not produce measurable changes in the muscle tissue suggesting a central mechanism mediating the enhancement of hyperalgesia.Perspective-These data therefore show that muscle fatigue can enhance the likelihood that one develops pain to a mild insult. Clinically, this could relate to the development of pain from such conditions as repetitive strain injury, and may relate to the interrelationship between chronic pain and fatigue. KeywordsFatigue; exercise; acid; protons; low-pH saline Pain arising from musculoskeletal disorders is a major clinical problem globally, 58 and fibromyalgia affects 2% of population in the United States. 57 As high as 76% of people with chronic widespread musculoskeletal pain conditions, such as fibromyalgia and arthritis, also report fatigue. 26 Conversely, as high as 94% of people with chronic fatigue syndrome report musculoskeletal pain and approximately half of the population has chronic widespread musculoskeletal pain. 56,60 Pain is increased during and after exercise in people with fibromyalgia and chronic fatigue syndrome. 20,48,54,55 Similarly, muscle fatigue is increased in people with chronic fatigue syndrome. 3,10,23 To assess mechanisms of chronic widespread pain, we developed an animal model that mimics the clinical symptoms. Two injections of acidic saline (pH 4.0), 5 days apart, into 1 muscle results in bilateral long-lasting hyperalgesia of the paw, 41 muscle,59 and the viscera28 without muscle tissue damage.41 The intramuscular pH decreases to a p...

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Section: Peripheral Mechanisms For Enhanced Nociception After Fatiguecontrasting

confidence: 55%

Muscle Fatigue Increases the Probability of Developing Hyperalgesia in Mice

Yokoyama

Lisi

Moore

et al. 2007

The Journal of Pain

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“…High-intensity interval training has been shown to be an effective method for improving endurance performance [7][8][9]. The antioxidant enzymes may be activated selectively during an acute bout of strenuous exercise depending on the oxidative stress imposed on the specific tissues as well as the intrinsic antioxidant defense capacity.…”

Section: Discussionmentioning

confidence: 99%

Effect of High Intensity Interval Training On Antioxidants of Male Physical Education Students

Hassan

2014

IJPEFS

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The purpose of this study is to find out the efficiency of high intensity interval training on antioxidants of male physical education students. To achieve the purpose thirty (30) male physical education students were selected from Swami Vivekanand Subharti University, Department of Physical Education, Meerut, Utter Pradesh. These subjects were tested on antioxidants before and after eight weeks of high intensity interval training (HIIT). The mean maximal aerobic speed 4.21 m/s was used as a criterion velocity to set running paces for highintensity interval training. Statistical technique used in the present study was 2×2 ANOVA with repeated measures on last two factors. The result of the study revealed that eight weeks of high intensity interval training resulted in 32.65% of increase in Superoxide dismutase (SOD) (F (1,28) =4.663, p < 0.05) and 8.86% on Glutathione peroxidase (GPx) (F (1,28) = 14.88, p < 0.05). However, 4.92% of reduction is noticed in Catalase (CAT) (F (1,28) = 14.88, p < 0.05). It is concluded that high intensity interval training for eight weeks resulted in significant alterations in antioxidants and which indirectly lowered the lipid peroxidation of male physical education students.

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“…A large accumulation of lactate and H + during high intensity exercise may provide an important stimulus for adaptations of the muscle pH regulating systems (34). This finding is supported by increases in the muscle buffer capacity in response to high-intensity interval training (35). In addition, sprint training has been reported to increase the muscle buffer capacity, whereas endurance training showed no effect (36).…”

Section: Discussionmentioning

confidence: 84%

The Relationship between the Isocapnic Buffering Phase and Ventilatory Threshold in Endurance Athletes and Team Sport Athletes during an Incremental Exercise Test

Eryılmaz

Polat

Soyal³

et al. 2018

Ann. Appl. Sport Sci

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Background. There is sparse literature examining the ICB phase of aerobic-and anaerobic-trained athletes. Measurements of ICB phase values of athletes can help to evaluate the sport's physiological demands and understand the physiological adaptations in response to physical training. Objectives. The purpose of this study was to examine the relationship between the isocapnic buffering (ICB) phase and the maximal oxygen uptake (VO2max) as well as the ventilatory threshold (VT) in trained athletes. Methods. Twenty-eight male endurance athletes and forty male team sports athletes underwent an incremental treadmill test to determine their VT, respiratory compensation point (RCP), and VO2max. The ICB phase was calculated as the difference in Oxygen uptake (VO2) between the RCP and VT and expressed in either absolute or relative values. Results. The VO2max, maximal running speed, time to exhaustion, VO2 at the VT and RCP, running speed at the VT, and VT expressed as % VO2max was higher in the endurance athletes than in the team sport athletes (p < 0.01), whereas the RCP expressed as % VO2max and running speed at the RCP showed similar values in both groups (p > 0.05). Both the absolute and relative ICB phase values were found to be significantly higher in team sports athletes than in endurance athletes (p < 0.001). The relative ICB phase was significantly negatively correlated with the VO2max (-r = 0.517, p < 0.001), the VO2 at the VT (-r = 0.755, p < 0.001), and the VO2 at the RCP (r = -0.517, p = 0.001). Conclusion. The current findings suggest that, for trained athletes, the magnitude of the ICB phase is more closely related to the VT rather than the VO2max and RCP. Presumably, the high-intensity intermittent-type exercises performed by team sports athletes may have improved their buffering capacity, leading to a shift in the RCP without a change in the VT, and consequently enhancing the ICB phase.

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The effects of training intensity on muscle buffer capacity in females

Cited by 146 publications

References 40 publications

Muscle Fatigue Increases the Probability of Developing Hyperalgesia in Mice

Muscle Fatigue Increases the Probability of Developing Hyperalgesia in Mice

Effect of High Intensity Interval Training On Antioxidants of Male Physical Education Students

The Relationship between the Isocapnic Buffering Phase and Ventilatory Threshold in Endurance Athletes and Team Sport Athletes during an Incremental Exercise Test

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