The effects of transcranial static magnetic fields stimulation over the supplementary motor area on anticipatory postural adjustments

Tsuru, Daisuke; Watanabe, Tatsunori; Chen, Xiaoxiao; Kubo, Nami; Sunagawa, Toru; Mima, Tatsuya; Kirimoto, Hikari

doi:10.1016/j.neulet.2020.134863

Cited by 17 publications

(12 citation statements)

References 50 publications

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“…The SMC has efferent projections to the putamen and the caudate, which then project to the internal segment of the globus pallidus (GPi) and, through the hyperdirect pathway, to the STN [27]. Recently, the SMA has been linked to postural control [38][39][40][41]. In our study, higher structural connectivity between the VTA and right SMA was similarly associated with a larger improvement in postural angle abnormalities after STN-DBS surgery.…”

Section: Discussionsupporting

confidence: 50%

Subthalamic Stimulation for Camptocormia in Parkinson’s Disease: Association of Volume of Tissue Activated and Structural Connectivity with Clinical Effectiveness

Lai

Yang

Huang

et al. 2021

JPD

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Background: Deep brain stimulation of the subthalamic nucleus (STN-DBS) has been reported to be effective for camptocormia in Parkinson’s disease (PD). However, the association between clinical effectiveness and the stimulated volumes or structural connectivity remains unexplored. Objective: To investigate the effectiveness of STN-DBS for treating camptocormia in PD and its association with volumes of tissue activated (VTA) and structural connectivity. Methods: We reviewed video recordings of patients who had undergone STN-DBS. The total and upper camptocormia (TCC and UCC) angles were measured to quantify changes in camptocormia. The Movement Disorders Society Unified Parkinson’s Disease Rating Scale III (MDS-UPDRS III) was used to assess motor symptoms. Pre- and postoperative brain images were collected for modeling volume of VTA and structural connectivity using Lead-DBS software. Results: Participants included 36 patients with PD (8 with TCC-camptocormia and 2 with UCC-camptocormia) treated with bilateral STN-DBS. After surgery, patients showed a significant improvement in postural alignment at follow-up (mean follow-up duration: 6.0±2.2 months). In the entire sample, higher structural connectivity to the right supplementary motor area (SMA) and right lateral premotor cortex along the dorsal plane (PMd) was associated with larger postsurgical improvements in axial signs and TCC angles after stimulation was turned on. In patients diagnosed with camptocormia, larger improvement in camptocormia angles after STN-DBS was associated with a larger VTA overlap with STN (R = 0.75, p = 0.032). Conclusion: This study suggests that both VTA overlap with STN and structural connectivity to cortical motor regions are associated with the effectiveness of STN-DBS for managing camptocormia in PD.

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Section: Discussionsupporting

confidence: 50%

Subthalamic Stimulation for Camptocormia in Parkinson’s Disease: Association of Volume of Tissue Activated and Structural Connectivity with Clinical Effectiveness

Lai

Yang

Huang

et al. 2021

JPD

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“…At current understanding, even though there are many hypotheses, there is no firm conclusion as to what mechanism is responsible for the change in the central nervous system by tSMS. Nevertheless, tSMS has been consistently demonstrated to have an inhibitory effect on the cortical excitability in various areas, including the motor [1,11], somatosensory [14,52], visual [53,54], and temporal [55] cortices, as well as SMA [16,17] and cerebellar region [56].…”

Section: Putative Mechanisms Underlying Change In the Score Of Line Length Judgement Task By Tsms Over C6mentioning

confidence: 99%

“…Also, tSMS's ability to reduce the amplitude of intra-epidermal electrical stimulation-evoked potentials [15] may lead to the development of chronic pain management. Furthermore, findings that tSMS over the supplementary motor area (SMA) can modulate resting-state functional magnetic resonance imaging (fMRI) activity [16] and the function of postural adjustments [17] indicate its potential use as a therapeutic technique to suppress excessive activity of the SMA, for example, in patients who have such neurological disorders as Parkinson's disease and Gilles de la Tourette syndrome [18][19][20]. In addition, the suppression of epileptic seizures by tSMS observed in rats and monkeys [3] seems to be applicable even to humans.…”

Section: Introductionmentioning

confidence: 99%

Influence of Static Magnetic Field Stimulation on the Accuracy of Tachystoscopically Presented Line Bisection

et al. 2020

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Transcranial static magnetic stimulation (tSMS) has been known to reduce human cortical excitability. Here, we investigated whether tSMS would modulate visuo-spatial cognition in healthy humans. Subjects performed a visuo-spatial task requiring judgements about the symmetry of pre-bisected lines. Visual stimuli consisted of symmetrically or asymmetrically transected lines, tachystoscopically presented for 150 ms on a computer monitor. Task performance was examined before, immediately after, and 10 min after tSMS/sham stimulation of 20 min over the posterior parietal cortex (PPC: P4 from the international 10–20 system) or superior temporal gyrus (STG: C6). Nine out of 16 subjects misjudged pre-bisected lines by consistently underestimating the length of the right-side segment (judging lines to be exactly pre-bisected when the transector was located to the left of the midpoint, or judging the left-side segment to be longer when the transector was located at the midpoint). In these subjects showing a leftward bias, tSMS over the right STG reduced the magnitude of the leftward bias. This did not occur with tSMS over the right PPC or sham stimulation. In the remaining right-biased subjects, no intervention effect was observed with any stimulation. Our findings indicate that application of tSMS over the right STG modulates visuo-spatial cognition in healthy adults.

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“…In addition, from a behavioral perspective, tSMS over the M1 has been reported to facilitate offline motor learning [21], and to impair pinch force control [22]. Moreover, visual search performance can be modulated with tSMS over the occipital [15] or temporal areas [23], and anticipatory postural control can be impaired with tSMS over the supplementary motor area [24]. Taken together, available evidence indicates that tSMS is capable of modulating human brain function and behavior.…”

Section: Introductionmentioning

confidence: 99%

Transient Modulation of Working Memory Performance and Event-Related Potentials by Transcranial Static Magnetic Field Stimulation over the Dorsolateral Prefrontal Cortex

et al. 2021

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Transcranial static magnetic field stimulation (tSMS) can modulate human cortical excitability and behavior. To better understand the neuromodulatory effect of tSMS, this study investigates whether tSMS applied over the left dorsolateral prefrontal cortex (DLPFC) modulates working memory (WM) performance and its associated event-related potentials (ERPs). Thirteen healthy participants received tSMS or sham stimulation over the left DLPFC for 26 min on different days. The participants performed a 2-back version of the n-back task before, during (20 min after the start of stimulation), immediately after, and 15 min after the stimulation. We examine reaction time for correct responses, d-prime reflecting WM performance, and the N2 and P3 components of ERPs. Our results show that there was no effect of tSMS on reaction time. The d-prime was reduced, and the N2 latency was prolonged immediately after tSMS. These findings indicate that tSMS over the left DLPFC affects WM performance and its associated electrophysiological signals, which can be considered an important step toward a greater understanding of tSMS and its use in studies of higher-order cognitive processes.

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The effects of transcranial static magnetic fields stimulation over the supplementary motor area on anticipatory postural adjustments

Cited by 17 publications

References 50 publications

Subthalamic Stimulation for Camptocormia in Parkinson’s Disease: Association of Volume of Tissue Activated and Structural Connectivity with Clinical Effectiveness

Subthalamic Stimulation for Camptocormia in Parkinson’s Disease: Association of Volume of Tissue Activated and Structural Connectivity with Clinical Effectiveness

Influence of Static Magnetic Field Stimulation on the Accuracy of Tachystoscopically Presented Line Bisection

Transient Modulation of Working Memory Performance and Event-Related Potentials by Transcranial Static Magnetic Field Stimulation over the Dorsolateral Prefrontal Cortex

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