The effects of two Chinese herbal medicinal formulae vs. placebo controls for treatment of allergic rhinitis: a randomised controlled trial

Chan, Rose Yuk-Pui; Chien, Wai Tong

doi:10.1186/1745-6215-15-261

Cited by 23 publications

(26 citation statements)

References 31 publications

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“…27 For these reasons, traditional Chinese Medicine (TCM) composed of natural herbs has recently gained much attention as a potential source for therapeutic AR medicine. 28 SCRT is an herbal medicine widely used in both TKM and TCM for treating AR. Previous studies reported that SCRT exhibits antiallergic effects by inhibiting Th2 cytokine release and decreasing infiltration of inflammatory cells onto nasal mucosa in an ovalbumin-induced AR model.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of So-Cheong-Ryong-Tang in treatment of perennial allergic rhinitis: study protocol for a double-blind, randomised, parallel-group, multicentre trial

Kim

Ahn

et al. 2017

BMJ Open

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IntroductionSo-Cheong-Ryong-Tang (SCRT) is a herbal medicine widely used in traditional medicine for treating allergic rhinitis (AR). In animal studies, SCRT has suppressed the progression of AR. The main purpose of this study is to assess the efficacy and safety of the SCRT for the treatment of perennial allergic rhinitis (PAR) and discover the underlying mechanisms resulting in anti-inflammatory effects in humans.Methods and analysisWe will conduct a double-blind, randomised, placebo-controlled, parallel-group, multicentre trial of Korean adults with PAR. For the study, 156 subjects with PAR will be recruited. The trial will consist of a 4-week oral administration of SCRT or placebo with two visits at 2-week intervals and an 8-week follow-up period with two visits at 4-week intervals. The primary outcome is a change in the total nasal symptoms score. The secondary outcomes include changes in the Rhinoconjunctivitis Quality of Life Questionnaire score, total serum IgE and cytokines levels.Ethics and disseminationThis study was approved by the Institutional Review Board at each research centre (name of each centres and approval numbers): Kyung Hee University Hospital at Gangdong (KHNMC-OH-IRB 2015-04-009), Kyung Hee University Medical Centre (KOMCIRB-160321-HRBR-011), Pusan National University Hospital (2016–004), Dongguk University Medical Centre (2016–03) and Semyung University hospital (2016–01). This result will be published in a peer-reviewed journal.Trial registration numberNCT03009136; Pre-results.

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Section: Discussionmentioning

confidence: 99%

Efficacy and safety of So-Cheong-Ryong-Tang in treatment of perennial allergic rhinitis: study protocol for a double-blind, randomised, parallel-group, multicentre trial

Kim

Ahn

et al. 2017

BMJ Open

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“…Nasal decongestants are useful for nasal obstruction, but using them for more than a week is not recommended because of adverse effects and drug tolerance [ 18 ]. For these reasons, traditional Chinese medicines which are made with natural herbs have recently gained much interest [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Hyeonggaeyeongyo‐Tang for Treatment of Allergic and Nonallergic Rhinitis: A Prospective, Nonrandomized, Pre‐Post Study

Kim

Son

Nam

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Hyeonggaeyeongyo-tang (HYT) is an ancient formula of oriental medicine traditionally used to treat rhinitis; however, clinical evidence has not yet been established. The aim of this study was to investigate the short-term and long-term efficacy and safety of HYT for chronic rhinitis. Adult subjects with chronic rhinitis symptoms were recruited. The subjects received HYT for 4 weeks and had follow-up period of 8 weeks. Any medicines used to treat nasal symptoms were not permitted during the study. The skin prick test was performed to distinguish the subjects with allergic rhinitis from those with nonallergic rhinitis. After treatment, the total nasal symptoms score and the Rhinoconjunctivitis Quality of Life Questionnaire score significantly improved in the whole subject group, in the allergic rhinitis group, and in the nonallergic rhinitis group, with no adverse events. This improvement lasted during a follow-up period of 8 weeks. Total IgE and eosinophil levels showed no significant difference after treatment in the allergic rhinitis group. HYT improved nasal symptoms and quality of life in patients with allergic rhinitis and nonallergic rhinitis. This is the first clinical study to evaluate the use of HYT to treat patients with rhinitis. This trial has been registered with the ClinicalTrials.gov Identifier NCT02477293.

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“…Furthermore, Chinese Herbal Medicine (CHM) was found effective to reduce symptoms and enhance quality of life of patients with AR (Chan & Chien, 2014;Hon, Fung, Leung, Lam, & Lee, 2015;Lee et al, 2018;Zhang, Lan, Zhang, & Zhang, 2018). In the future, CHM may serve as an important supplementary means to AR treatment, although its specific biological mechanism remains to be further revealed.…”

Section: Arachidonic Acid Metabolismmentioning

confidence: 99%

Serum metabolomics study of patients with allergic rhinitis

Ma¹,

Wang

et al. 2020

Biomedical Chromatography

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Allergic rhinitis (AR) negatively affects the healthy lives of many individuals. Most previous studies on AR focused on the expression of cytokines, with only a few analyzing cytokine expression from a metabolomics viewpoint. Therefore, it is worthwhile to study AR at the metabolic level. Consequently, we aimed to identify differential serum biomarkers by metabolomics. In this study, the orthogonal partial least squares discriminant analysis (OPLS‐DA) model was applied to characterize the differences in serum samples collected from patients with AR and healthy volunteers. Ten metabolites (except hexadecanoic acid) were found to be altered significantly (p < .05) in the former group, according to results of principal component analysis and OPLS‐DA, indicating that these metabolites could be potential biomarkers. MetaboAnalyst 4.0 and pathway enrichment analysis showed that these changes in metabolites mainly involved three pathways, namely, porphyrin and chlorophyll metabolism, arachidonic acid metabolism, and purine metabolism. Our findings may contribute to a better understanding of the potential pathogenesis mechanisms and provide a metabolic evidence for in‐depth studies of AR.

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The effects of two Chinese herbal medicinal formulae vs. placebo controls for treatment of allergic rhinitis: a randomised controlled trial

Cited by 23 publications

References 31 publications

Efficacy and safety of So-Cheong-Ryong-Tang in treatment of perennial allergic rhinitis: study protocol for a double-blind, randomised, parallel-group, multicentre trial

Efficacy and safety of So-Cheong-Ryong-Tang in treatment of perennial allergic rhinitis: study protocol for a double-blind, randomised, parallel-group, multicentre trial

Hyeonggaeyeongyo‐Tang for Treatment of Allergic and Nonallergic Rhinitis: A Prospective, Nonrandomized, Pre‐Post Study

Serum metabolomics study of patients with allergic rhinitis

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