The effects of UK 2054 on the multiplication of influenza viruses

Abstract

SummaryThe isoquinoline compound UK 2054 prevents the uptake of influenza virus by susceptible cells. Pre-incubation of virus particles with 500μg./ml. UK 2054 at 37°C. for 2 hr. does not reduce virus infectivity. Host cells vary in their responsiveness to the inhibitory effect of UK 2054; virus multiplication is inhibited in chick allantoic cells by lower concentrations than those required to inhibit virus growth in chick embryo fibroblasts. The effectiveness of UK 2054 is reduced by the presence of serum.It is concluded that inhibition of influenza virus multiplication by UK2054 might result from interaction of the inhibitor with both virus and cells. Any direct combination between inhibitor and virus is completely reversible.

Antiinfluenzal Effect of Rugulosin

“…Isoquinoline derivatives have been known as antiviral agents directly inactivating influenza virus [1,2,4] like rugulosin. However, they only reduce the infectivity titer of influenza virus.…”