“…The interventions in these studies involved diverse technologies across the categories, that is, audio [ 33 , 49 ], light [ 42 ], sleep aids [ 19 ], communication support [ 21 ], others [ 46 ], and multiple components [ 24 , 51 , 52 ]. Of the 14 studies without significant effect on direct outcome measures, 8 studies, however, showed significant effects on delirium risk factors or symptoms, including pain [ 40 ], anxiety [ 35 , 36 , 38 , 50 ], agitation [ 54 ], hallucination [ 54 ], and factual memory encoding [ 45 ]. Six of the 8 studies using diverse technology-based interventions showed a significant effect on indirect outcome measures, including anxiety [ 39 ], agitation [ 43 ], sleep deprivation [ 44 ], or ICU readmission [ 59 ].…”