The Effects of Vitamin B in Depression

Mikkelsen, Kathleen; Stojanovska, Lily; Apostolopoulos, Vasso

doi:10.2174/0929867323666160920110810

Cited by 137 publications

(103 citation statements)

References 96 publications

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“…The major discovery of the present study is that VitB6 produces several beneficial effects to prevent inflammation in lung. Traditionally, VitB6 may treat depression, stroke, anaemia, nausea during pregnancy, clogged arteries, eye diseases, diabetes and inflammation associated with rheumatoid arthritis . Recently, we have identified that VitB6 improves insulin resistance in Apoe −/− mice fed with high‐fat diet and prevents isocarbophos‐induced vascular dementia in rats .…”

Section: Discussionmentioning

confidence: 99%

Vitamin B6 inhibits macrophage activation to prevent lipopolysaccharide‐induced acute pneumonia in mice

Shan

Zhou

et al. 2020

J Cellular Molecular Medi

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Macrophage activation participates in the pathogenesis of pulmonary inflammation. As a coenzyme, vitamin B6 (VitB6) is mainly involved in the metabolism of amino acids, nucleic acids, glycogen and lipids. We have previously reported that activation of AMP‐activated protein kinase (AMPK) produces anti‐inflammatory effects both in vitro and in vivo. Whether VitB6 via AMPK activation prevents pulmonary inflammation remains unknown. The model of acute pneumonia was induced by injecting mice with lipopolysaccharide (LPS). The inflammation was determined by measuring the levels of interleukin‐1 beta (IL‐1β), IL‐6 and tumour necrosis factor alpha (TNF‐α) using real time PCR, ELISA and immunohistochemistry. Exposure of cultured primary macrophages to VitB6 increased AMP‐activated protein kinase (AMPK) Thr172 phosphorylation in a time/dose‐dependent manner, which was inhibited by compound C. VitB6 downregulated the inflammatory gene expressions including IL‐1β, IL‐6 and TNF‐α in macrophages challenged with LPS. These effects of VitB6 were mirrored by AMPK activator 5‐aminoimidazole‐4‐carboxamide ribonucleoside (AICAR). However, VitB6 was unable to inhibit LPS‐induced macrophage activation if AMPK was in deficient through siRNA‐mediated approaches. Further, the anti‐inflammatory effects produced by VitB6 or AICAR in LPS‐treated macrophages were abolished in DOK3 gene knockout (DOK3−/−) macrophages, but were enhanced in macrophages if DOK3 was overexpressed. In vivo studies indicated that administration of VitB6 remarkably inhibited LPS‐induced both systemic inflammation and acute pneumonia in wild‐type mice, but not in DOK3−/− mice. VitB6 prevents LPS‐induced acute pulmonary inflammation in mice via the inhibition of macrophage activation.

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Section: Discussionmentioning

confidence: 99%

Vitamin B6 inhibits macrophage activation to prevent lipopolysaccharide‐induced acute pneumonia in mice

Shan

Zhou

et al. 2020

J Cellular Molecular Medi

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“…Vitamins are dietary components that are required for the proper function of the methylation cycle, monoamine oxidase production, DNA synthesis, and phospholipid repair and maintenance [15,16]. They play a major role in health, and their deficiencies may be linked to symptoms of neuronal dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Lack of Association between Serum Vitamin B6, Vitamin B12, and Vitamin D Levels with Different Types of Glaucoma: A Systematic Review and Meta-Analysis

Shao

et al. 2017

Nutrients

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Although vitamins play a major role in health, and their deficiency may be linked to symptoms of optic-nerve dysfunction, the association between serum vitamin levels and glaucoma in humans remains controversial. In this study, articles in the PubMed, Web of Science, and EMBASE databases were searched up to 25March 2017. Nine studies on primary open-angle glaucoma (POAG), four studies on normal tension glaucoma (NTG), and six studies on exfoliative glaucoma (EXG) were retrieved. The combined results showed no differences in the levels of serum vitamin B6 between POAG (p = 0.406) and EXG (p = 0.139) patients and controls. The weighted mean differences (WMDs) with 95% confidence intervals (CIs) were 2.792 ng/mL (−3.793 to 9.377) and 1.342 ng/mL (−3.120 to 0.436), respectively. There was no difference between POAG (p = 0.952), NTG (p = 0.757), or EXG (p = 0.064) patients and controls in terms of serum vitamin B12. The WMDs with 95% CIs were 0.933 pg/mL (−31.116 to 29.249), 6.652 pg/mL (−35.473 to 48.777), and 49.946 pg/mL (−102.892 to 3.001), respectively. The serum vitamin D levels exhibited no differences (p = 0.064) between POAG patients and controls; the WMD with 95% CI was 2.488 ng/mL (−5.120 to 0.145). In conclusion, there was no association found between serum vitamin B6, vitamin B12, or vitamin D levels and the different types of glaucoma.

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“…They play a major role in health and their deficiency may be linked to symptoms of psychiatric disorders. [35] Studies on depression have shown that low folate and vitamin B12 serum levels seem to be associated with depression in the aged. [36,37] Systemic folate deficiency has been associated with macrocytic anemia and neuropsychiatric phenotypes.…”

Section: Discussionmentioning

confidence: 99%

Determination of vitamin B12, folate, and ferritin levels of inpatients in a psychiatry clinic: A one-year retrospective study

Örüm¹

2018

FNG & Bilim Tıp Dergisi

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Objectives:This study aims to compare the vitamin B12, folate, and ferritin levels of inpatients in a psychiatry clinic. Materials and methods:The study included 286 inpatients (178 males, 108 females; mean age 35.4±12.9 years; range, 15 to 76 years) treated in Adiyaman University Training and Research Hospital psychiatry clinic between 01 January 2017 and 31 December 2017. Patients' diagnoses and vitamin B12, folate, and ferritin levels were examined retrospectively. Results:The most common diagnoses were schizophrenia (23.4%), bipolar affective disorder (23.1%), and major depressive disorder (11.5%). While there was no significant difference in vitamin B12 levels according to sex (p=0.850), folate level was significantly lower in males (p=0.001) and ferritin level was significantly lower in females (p=0.001). No difference was detected in the levels of vitamin B12, folate and ferritin in the comparison between diagnoses. Conclusion: Deficiency in vitamin B12, folate, and ferritin levels may cause psychiatric symptoms. Due to the high number of patients with low vitamin B12 levels in our study, more attention may be paid to vitamin B12 replacement. Ferritin deficiency in females and folate deficiency in males are noteworthy. Further research are needed to identify more specific and detailed algorithms related to vitamin B12, folate, and ferritin to support the findings of this study and optimize the care given to patients suffering from psychiatric syndromes. Bulgular: En sık görülen tanılar şizofreni (%23.4), bipolar affektif bozukluk (%23.1) ve majör depresif bozukluk (%11.5) idi. Cinsiyete göre B12 vitamini düzeylerinde anlamlı farklılık yokken (p=0.850) erkeklerde folat düzeyi (p=0.001) ve kadınlarda ferritin düzeyi (p=0.001) anlamlı olarak düşük idi. Tanılar arasındaki karşılaştırmada; B12 vitamini, folat ve ferritin düzeyleri arasında farklılık tespit edilmedi. Sonuç: B12 vitamini, folat ve ferritin düzeylerinde eksiklik psikiyatrik semptomlara neden olabilir. Çalışmamızda B12 vitamini düzeyi düşük olan hasta sayısının fazla olmasına bağlı olarak B12 vitamini replasmanında daha dikkatli olunabilir. Kadınlardaki ferritin eksikliği ve erkeklerdeki folat eksikliği dikkat çekicidir. Bu çalışmanın bulgularını desteklemek ve psikiyatrik sendromu olan hastalara verilen bakımın optimize edilmesi için B12 vitamini, folat ve ferritine ilişkin daha spesifik ve ayrıntılı algoritmaları belirlemek amacıyla ileri araştırmalar gerekmektedir.Anahtar sözcükler: Ferritin; folik asit; yatan hastalar; psikiyatri; retrospektif çalışma; B12 vitamini.

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The Effects of Vitamin B in Depression

Cited by 137 publications

References 96 publications

Vitamin B6 inhibits macrophage activation to prevent lipopolysaccharide‐induced acute pneumonia in mice

Vitamin B6 inhibits macrophage activation to prevent lipopolysaccharide‐induced acute pneumonia in mice

Lack of Association between Serum Vitamin B6, Vitamin B12, and Vitamin D Levels with Different Types of Glaucoma: A Systematic Review and Meta-Analysis

Determination of vitamin B12, folate, and ferritin levels of inpatients in a psychiatry clinic: A one-year retrospective study

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