The Effects of Vitamin C on the Multiple Pathophysiological Stages of COVID-19

Miranda-Massari, Jorge R.; Toro, Alondra P; Loh, Doris; Rodríguez, José Ramón; Borges, Raul Morales; Marcial-Vega, Víctor; Olalde, Jose; Berdiel, Miguel J.; Riordan, Neil H; Martinez, Juan Manuel; Gil, Armando; González, Michael J.

doi:10.3390/life11121341

Cited by 11 publications

(10 citation statements)

References 110 publications

(111 reference statements)

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“…At pharmacological doses, vitamin C is beneficial to patients affected by CARDS and other respiratory illnesses. Moreover, high-dose intravenous vitamin C (HDIVC) may be advantageous in patients with diverse viral diseases [ 81 ]. The antiviral activity of vitamin C is due to the support of lymphocyte activity, enhancement of interferon-α production, and modulation of cytokines, which lowers inflammation, improving endothelial dysfunction and restoring mitochondrial function.…”

Section: Nutraceuticals and Dietary Supplements Against Covid-19 Dise...mentioning

confidence: 99%

Are Nutraceuticals Effective in COVID-19 and Post-COVID Prevention and Treatment?

Catalano

Iacopetta

Ceramella

et al. 2022

Foods

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The beginning of the end or the end of the beginning? After two years mastered by coronavirus disease 19 (COVID-19) pandemic, we are now witnessing a turnaround. The reduction of severe cases and deaths from COVID-19 led to increasing importance of a new disease called post-COVID syndrome. The term post-COVID is used to indicate permanency of symptoms in patients who have recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Immune, antiviral, antimicrobial therapies, as well as ozone therapy have been used to treat COVID-19 disease. Vaccines have then become available and administered worldwide to prevent the insurgence of the disease. However, the pandemic is not over yet at all given the emergence of new omicron variants. New therapeutic strategies are urgently needed. In this view, great interest was found in nutraceutical products, including vitamins (C, D, and E), minerals (zinc), melatonin, probiotics, flavonoids (quercetin), and curcumin. This review summarizes the role of nutraceuticals in the prevention and/or treatment of COVID-19 disease and post-COVID syndrome.

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Section: Nutraceuticals and Dietary Supplements Against Covid-19 Dise...mentioning

confidence: 99%

Are Nutraceuticals Effective in COVID-19 and Post-COVID Prevention and Treatment?

Catalano

Iacopetta

Ceramella

et al. 2022

Foods

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“…The intravenous usage of antioxidants in severe cases of infection is due to their ability to inhibit cytokine storms [ 177 ]. VC has been proven in animal and tissue models to modulate the immunological system by enhancing interferon production, suppressing oxidative stress and thrombosis, inhibiting cytokine storms, and lessening alveolar damage, and it has many other effects on the human body [ 178 ]. It is also known to enhance the maturation and proliferation of lymphocytes.…”

Section: Vitamin Cmentioning

confidence: 99%

The Variable Nature of Vitamin C—Does It Help When Dealing with Coronavirus?

et al. 2022

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still spreading worldwide. For this reason, new treatment methods are constantly being researched. Consequently, new and already-known preparations are being investigated to potentially reduce the severe course of coronavirus disease 2019 (COVID-19). SARS-CoV-2 infection induces the production of pro-inflammatory cytokines and acute serum biomarkers in the host organism. In addition to antiviral drugs, there are other substances being used in the treatment of COVID-19, e.g., those with antioxidant properties, such as vitamin C (VC). Exciting aspects of the use of VC in antiviral therapy are its antioxidant and pro-oxidative abilities. In this review, we summarized both the positive effects of using VC in treating infections caused by SARS-CoV-2 in the light of the available research. We have tried to answer the question as to whether the use of high doses of VC brings the expected benefits in the treatment of COVID-19 and whether such treatment is the correct therapeutic choice. Each case requires individual assessment to determine whether the positives outweigh the negatives, especially in the light of populational studies concerning the genetic differentiation of genes encoding the solute carriers responsible forVC adsorption. Few data are available on the influence of VC on the course of SARS-CoV-2 infection. Deducing from already-published data, high-dose intravenous vitamin C (HDIVC) does not significantly lower the mortality or length of hospitalization. However, some data prove, among other things, its impact on the serum levels of inflammatory markers. Finally, the non-positive effect of VC administration is mainly neutral, but the negative effect is that it can result in urinary stones or nephropathies.

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“…Vitamin C boost up immune system functions such as lymphocyte proliferation, antimicrobial activity, anti-natural killer cell activity [28]. SARS-CoV-2 impacts on the levels of vitamin C due to stress in Covid-19 patients, as a result vitamin C is mandatory for SARS-CoV-2 infected patients [29].…”

Section: Drugs Prescribedmentioning

confidence: 99%

Observational Study of Covid-19 Cases and Off-label Drugs to Manage Complications during First and Second Wave

Das

Doddikindi

Thoda

et al. 2022

JPRI

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Background: Initially Covid-19 complication treatment was almost nil and focused only on supportive measures. Various off-label drugs were utilized globally to obtain better outcomes; the same was practiced by the Indian healthcare fraternity. We have aimed to review the utilization of off-label medicines like Vitamin C, Azithromycin, Ivermectin, Doxycycline, Low Molecular Weight Heparin, Zinc, Remdesivir, Dexamethasone, etc. prescribed in Covid-19 nodal hospital of Telangana state, India. Methodology: A retrospective review and prospective observational study were conducted in the Covid-19 units of Gandhi medical college and hospital, Secunderabad between December 2020 and May 2021. The study was conducted after obtaining the necessary permission. In a retrospective review; previously published reports were analyzed to correlate the off-label medicine prescription for Covid-19 complications. Prospective case analysis was performed to access the outcome of drugs prescribed in Covid-19 complication and identified as off-label. Results: A total of 60 prescriptions were analyzed. Among these; Vitamin-C, Dexamethasone, and Azithromycin were prescribed in 67%, 43%, and 37% cases respectively. The study further revealed that hypertension and diabetes mellitus were the two most commo comorbidities that lead to hospitalization and subsequently required aggressive treatment to manage the Covid-19 related complications. Bilateral pneumonia was the most frequently appearing complication and therefore Dexamethasone and Azithromycin were listed as top off-label drugs to manage the same. Conclusion: Due to the lack of specific treatment available initially to manage Covid-19 complications, off-label medicines not only aided enormously in recovering from the complication but also demonstrated to the world that the right choice of off-label medicine can greatly reduce the risk.

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The Effects of Vitamin C on the Multiple Pathophysiological Stages of COVID-19

Cited by 11 publications

References 110 publications

Are Nutraceuticals Effective in COVID-19 and Post-COVID Prevention and Treatment?

Are Nutraceuticals Effective in COVID-19 and Post-COVID Prevention and Treatment?

The Variable Nature of Vitamin C—Does It Help When Dealing with Coronavirus?

Observational Study of Covid-19 Cases and Off-label Drugs to Manage Complications during First and Second Wave

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