The Effects of Vitamin D on Metabolic Profiles in Women with Polycystic Ovary Syndrome: A Systematic Review

Abstract

This systematic review aims to evaluate all epidemiological evidence in the literature linking the effect of vitamin D supplementation to metabolic and hormonal functions in women with polycystic ovary syndrome. The literature search was performed with two databases, namely Medline/PubMed and Web of Science, until 20 May 2019 for both observational and experimental studies concerning relationships between vitamin D and polycystic ovary syndrome. A total of ten studies with randomized, double-blinded, and placebo-controlled trial design from 2008 to 2019 were selected for this review. The inclusion criteria were women 18–45 years of age with polycystic ovary syndrome and comparing the metabolic or endocrine parameters between placebo and vitamin D supplementation groups. A total of ten studies were selected for this review. We found that vitamin D supplementation had a significant effect on insulin metabolism, total serum testosterone, hirsutism, C-reactive protein, and total antioxidant capacity in women with polycystic ovary syndrome. Evidence from available randomized controlled trials suggests that patients with polycystic ovary syndrome should take vitamin D supplementation for the beneficial effect of metabolic profiles. However, future research is needed regarding the beneficial effects in women who are non-obese with polycystic ovary syndrome, as well as more studies with larger sample sizes.

Vitamin D & E Supplemental Therapy could reduce Insulin resistance and control PCOS-specific Inflammatory and Oxidative Stresses

“…In line with these results multiple recent studies documented that oral VD supplemental therapy significantly decreased serum fasting blood glucose and serum insulin, TC, TG and VLDL-C, thus exerting favorable effects on glucose metabolism and lipid metabolism, especially in VD deficient PCOS women [30,31,32] . Furthermore, other recent studies documented the favorable effect of VD supplemental therapy on patients' lipid profile, oxidative stress and inflammatory status [33,34,35] and additionally reported improvement of endometrial receptivity [33] , hirsutism [34] and ovulation rate in subfertile women with PCOS undergoing induction of ovulation [35] .…”

Serum 25-Hydroxyvitamin D Concentrations and Cardiometabolic Biomarkers in Chinese Rural Population

“…However, there are also interventional studies, which provided divergent results [34][35][36]. Wamberg et al found no treatment effect of high-dose vitamin D (7000 IU/day) for 26 weeks on blood pressure, lipid profile, and HOMA-IR in obese adults [35].…”

“…Wamberg et al found no treatment effect of high-dose vitamin D (7000 IU/day) for 26 weeks on blood pressure, lipid profile, and HOMA-IR in obese adults [35]. A recent meta-analysis in 2020 summarized that the use of vitamin D supplementation did not influence glucose parameters but improved other metabolic profiles in participants with polycystic ovary syndrome, especially when combined with calcium [36]. Taken together, the inconsistent results from the available evidence may attribute to the fact that most of the studies were short in duration, had different baseline 25(OH)D and metabolic profile, or used post-hoc analysis.…”

Vitamin D has therapeutic effects on obesity and hyperandrogenemia in PCOS mouse model induced by low dose DHEA and high-fat diet

“…Meanwhile, Vit.D and calcium therapy normalize the menstrual cycles in PCOS 9 . Further, studies have shown the therapeutic effects of Vit.D on hormone imbalances and metabolic disorder in women with PCOS, such as hyperandrogenism, hyperlipemia and insulin resistance, and high dose of Vit.D was recommended [10][11][12] . These ndings support the hypothesis that Vit.D de ciency may contribute to the development of PCOS, and Vit.D may be a feasible treatment for PCOS.…”