The effects of vitamin D on skeletal muscle function and cellular signaling

Dirks‐Naylor, Amie J.; Lennon-Edwards, Shannon

doi:10.1016/j.jsbmb.2011.03.003

Cited by 104 publications

(73 citation statements)

References 95 publications

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“…Concordant evidence suggests that vitamin D affects striated muscle cell biology. 21 Indeed, invalidation of VDR in mice reduced muscle diameters, 22 and consistent studies found an association between low 25(OH)D and reduced muscle strength in elderly people. 21 In addition, two studies reported an association between low 25(OH)D levels and fatty degeneration of thigh and rotator cuff muscles.…”

Section: Discussionmentioning

confidence: 90%

“…21 Indeed, invalidation of VDR in mice reduced muscle diameters, 22 and consistent studies found an association between low 25(OH)D and reduced muscle strength in elderly people. 21 In addition, two studies reported an association between low 25(OH)D levels and fatty degeneration of thigh and rotator cuff muscles. 23,24 This potential effect of vitamin D on muscle biology is likely to affect creatinine production.…”

Section: Discussionmentioning

confidence: 90%

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Vitamin D Status and Outcomes After Renal Transplantation

Bienaimé

Girard

Anglicheau

et al. 2013

Journal of the American Society of Nephrology

100

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Kidney transplant recipients usually have low vitamin D levels, especially in the early posttransplantation period, but the association between vitamin D status with renal outcomes is not well described in this population. Here, we studied a prospective cohort of 634 kidney recipients who underwent transplantation at a single institution between January 2005 and June 2010. In this cohort, low 25-hydroxyvitamin D concentrations 3 months after transplantation did not predict early death or graft loss but were independently associated with lower measured GFR at 12 months (P=0.001) and higher risk for interstitial fibrosis and tubular atrophy (P=0.01). In contrast, levels of calcium, phosphorus, calcitriol, parathyroid hormone, or fibroblast growth factor-23 were not consistently associated with any of the studied outcomes. In conclusion, low 25-hydroxyvitamin D concentration measured 3 months after transplantation is an independent risk factor for interstitial fibrosis progression and is associated with a lower GFR 1 year after transplantation. 24: 831-841, 201324: 831-841, . doi: 10.1681 Kidney transplantation is the preferred treatment for the increasing number of patients with ESRD. Transplantation allows patients to avoid the heavy constraints associated with dialysis therapy and is associated with a lower mortality and morbidity than is hemodialysis. 1 Evolution of GFR in transplant recipients appears to be imprinted at an early stage after the surgery. Indeed, the estimated GFR (eGFR) reached 1 year after transplantation is critically associated with allograft outcome. 2,3 This observation prompts research on modifiable factors affecting GFR in the first year after transplantation. J Am Soc NephrolVitamin D is a critical hormone controlling mineral homeostasis. It promotes phosphate and calcium absorption by the gut and increases calcium reabsorption by the renal distal tubule, thereby providing the positive calcium and phosphorus flux required for bone mineralization.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 90%

Vitamin D Status and Outcomes After Renal Transplantation

Bienaimé

Girard

Anglicheau

et al. 2013

Journal of the American Society of Nephrology

100

View full text Add to dashboard Cite

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“…There is growing evidence that vitamin D exerts several effects in skeletal muscle, including enhanced muscle strength, function and performance in general. Cell culture models suggested muscle vitamin D role in calcium handling, proliferation and differentiation, protection against insulin-resistance and arachidonic acid mobilization [6] . Vitamin D probably exerts its effects both indirectly, through calcium and phosphate pathways, and directly via binding of 1,25-dihydroxyvitamin D (1,25D) to the vitamin D receptor, that seems to be expressed in skeletal muscle cells, even if this topic is still under research [5,6] .…”

Section: Vitamin D and Skeletal Musclementioning

confidence: 99%

“…Cell culture models suggested muscle vitamin D role in calcium handling, proliferation and differentiation, protection against insulin-resistance and arachidonic acid mobilization [6] . Vitamin D probably exerts its effects both indirectly, through calcium and phosphate pathways, and directly via binding of 1,25-dihydroxyvitamin D (1,25D) to the vitamin D receptor, that seems to be expressed in skeletal muscle cells, even if this topic is still under research [5,6] . It has been supposed that the vitamin D relationship with muscle strength may influence the increasing risk of accidental falls in the elderly [6] .…”

Section: Vitamin D and Skeletal Musclementioning

confidence: 99%

“…Vitamin D probably exerts its effects both indirectly, through calcium and phosphate pathways, and directly via binding of 1,25-dihydroxyvitamin D (1,25D) to the vitamin D receptor, that seems to be expressed in skeletal muscle cells, even if this topic is still under research [5,6] . It has been supposed that the vitamin D relationship with muscle strength may influence the increasing risk of accidental falls in the elderly [6] . Vitamin D deficiency is associated with proximal muscle weakness and reduction in performance speed, probably related to selective muscle atrophy of type Ⅱ muscle fibers [5,6] .…”

Section: Vitamin D and Skeletal Musclementioning

confidence: 99%

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Imaging of skeletal muscle in vitamin D deficiency

Bignotti

Cadoni

Martinoli

et al. 2014

WJR

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Elderly people are prone to accidental falls and one of the main risk factor is considered muscle weakness. Several studies focused on muscle weakness and muscle morphology changes in the elderly that may be associated with vitamin D deficiency. The prevalence of vitamin D deficiency is higher than previously though representing an important issue for public health and prevention. There is an increased interest in vitamin D effects in skeletal muscle and imaging modalities are particularly involved in this field. In patients with vitamin D deficiency, ultrasound, computed tomography, densitometry and magnetic resonance imaging (MRI) can efficiently describe changes in muscle morphology and size. Moreover, new imaging modalities, such as MRI spectroscopy, may improve knowledge about the metabolic effects of vitamin D in skeletal muscle. In this narrative review we will discuss the role of skeletal muscle imaging in vitamin D-deficient individuals. The aim of this paper is to improve and encourage the role of radiologists in this field.

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Sarcopenia, Osteoporosis and Fractures

Cederholm

2012

Sarcopenia

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The effects of vitamin D on skeletal muscle function and cellular signaling

Cited by 104 publications

References 95 publications

Vitamin D Status and Outcomes After Renal Transplantation

Vitamin D Status and Outcomes After Renal Transplantation

Imaging of skeletal muscle in vitamin D deficiency

Sarcopenia, Osteoporosis and Fractures

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