The effects of whole body vibration and exercise on fibrinolysis in men

Boyle, Leryn J.; Nagelkirk, Paul R.

doi:10.1007/s00421-010-1590-8

Cited by 9 publications

(10 citation statements)

References 41 publications

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“…In a study on 20 healthy young men Boyle and Nagelkirk concluded that WBV combined with squatting exercise increases fibrinolytic activity more than exercise alone. [ 31 ] During WBV exercise there is an enhancement of skin blood flow, as measured by laser Doppler flowmetry. [ 32 33 34 ] This increase in blood flow may result in an increase in shear stress on blood vessels.…”

Section: Discussionmentioning

confidence: 99%

Effects of Whole Body Vibration Training on Inflammatory Markers in Young Healthy Males

Ghazalian

2019

Ann Mil Health Sci Res

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Background:The aim was to evaluate effects of 5-week whole body vibration (WBV) training with different amplitudes and progressive frequencies on fibrinolytic/coagulative factors.Materials and Methods:25 subjects were divided randomly in high or low-amplitude vibration, and control groups. Training consisted of 5-week WBV with amplitudes 4 or 2 mm. Plasma samples were analyzed before and after training. Statistical analysis was done using one-way analysis of variance and Wilcoxon signed ranked test. P <0.05 was considered significant.Results:High-amplitude vibration caused an increase in tissue plasminogen activator (tPA) (P = 0.028) (pretest: 1744.61 ± 707.95; posttest: 2313.63 ± 997.19 pg/ml), and decrease in plasminogen activator inhibitor-1 (PAI-1) (P = 0.033) (pretest: 97.94 ± 34.37; posttest: 85.12 ± 36.92 ng/ml). Fibrinogen and plasminogen were not changed significantly. Low-amplitude vibration caused an increase in tPA (P = 0.006) (pretest: 2208.18 ± 1280.37; posttest: 3492.72 ± 3549.22 pg/ml). PAI-1, fibrinogen and plasminogen were not changed significantly. There were no significant differences between groups.Conclusion:Amplitude of vibrations in WBV training may affect fibrinolytic factors.

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Section: Discussionmentioning

confidence: 99%

Effects of Whole Body Vibration Training on Inflammatory Markers in Young Healthy Males

Ghazalian

2019

Ann Mil Health Sci Res

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“…However, all other authors from the BBR2‐2 study concluded that further countermeasure optimization is required. Whole‐body vibration was recently shown to augment fibrinolytic activity in healthy men when combined with squatting exercises (Boyle and Nagelkirk ). Therefore, one could speculate that RVE during bed rest may also activate fibrinolysis.…”

Section: Discussionmentioning

confidence: 99%

Effects of long-term head-down-tilt bed rest and different training regimes on the coagulation system of healthy men

et al. 2013

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Immobility plus preexisting chronic disease or acute trauma can activate the coagulation system, thus increasing the risk for thromboembolic events. The effects of long-term bed-rest immobility and microgravity on the coagulation system of healthy persons (e.g., during crewed Mars missions) have not yet been studied. The main objective of the second Berlin BedRest Study (BBR2-2) “Coagulation Part” was to investigate adaptations of the hemostatic system during long-term bed rest (60 days) under simulated microgravity (6° head-down-tilt [6°HDT]) and after mobilization in three different volunteer groups (randomly assigned to CTR= inactive control group; RE= resistive exercise only group; and RVE= resistive exercise with whole-body vibration group). In 24 males (aged 21–45 years), before, during, and after long-term bed rest, key parameters of coagulation were measured from venous blood samples: D-dimer (DD), thrombin–antithrombin III complex (TAT), and prothrombin fragment F1 + 2 (PT-F1 + 2). Additionally, modified rotational thrombelastometry (ROTEM®) analysis was performed. Times of exploratory analyses were as follows: baseline data collection 2 days before bed rest (BDC-2); eight different days of 6°HDT bed rest (HDT1–HDT60), and two different days after reambulation (R + 3 and R + 6). We found significant changes in DD, TAT, and PT-F1 + 2 over the total time course, but no consistent effect of physical interventions (RE, RVE) on these parameters. Notably, no parameter reached levels indicative of intravascular thrombin formation. All ROTEM® parameters remained within the normal range and no pathological traces were found. Sixty days of 6°HDT bed rest are not associated with pronounced activation of the coagulation system indicative of intravascular thrombus formation in healthy volunteers independent of the training type during the bed rest.

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“…47 Similarly, whole-body vibration training and exercise significantly reduces the levels of PAI-1. 48 In 1990, Nilsson and colleagues undertook an interesting study to investigate how dietary habits influence the components of the fibrinolytic system, including PAI-1. The authors observed that consumption of fruits and vegetables was inversely correlated with systemic levels of PAI-1, and study participants that consumed maximum fruits and vegetables show lowest levels of PAI-1.…”

Section: How Can We Control Our Pai-1 Levels To Facilitate Good Health?mentioning

confidence: 99%

Plasminogen Activator Inhibitor-1 Is a Marker and a Mediator of Senescence

Vaughan

Rai

Khan

et al. 2017

ATVB

189

130

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Plasminogen Activator Inhibitor-1 (PAI-1) is a member of the evolutionarily conserved serine protease inhibitor (SERPIN) family, and a potent and rapid-acting inhibitor of both of the mammalian plasminogen activators. Organismal homeostasis requires physiological levels of endogenous PAI-1 and increased PAI-1 production guides the onset and progression of numerous human diseases and contributes to the multimorbidity of aging. Both chronological and stress-induced accelerated aging are associated with cellular senescence and accompanied by marked increases in PAI-1 expression in tissues. Recent studies suggest that PAI-1 is not only a marker but also a key mediator of cellular senescence and organismal aging. Here, we review the significance of PAI-1 as a bonafide marker as well as a critical mediator of cellular senescence associated with aging and aging-related pathologies.

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The effects of whole body vibration and exercise on fibrinolysis in men

Cited by 9 publications

References 41 publications

Effects of Whole Body Vibration Training on Inflammatory Markers in Young Healthy Males

Effects of Whole Body Vibration Training on Inflammatory Markers in Young Healthy Males

Effects of long-term head-down-tilt bed rest and different training regimes on the coagulation system of healthy men

Plasminogen Activator Inhibitor-1 Is a Marker and a Mediator of Senescence

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