The Effects of Xenon Anesthesia on the Relationship Between Cerebral Glucose Metabolism and Blood Flow in Healthy Subjects: A Positron Emission Tomography Study

Laitio, Ruut; Långsjö, Jaakko; Aalto, Sargo; Kaisti, Kaike K.; Salmi, Elina; Maksimow, Anu; Aantaa, Riku; Oikonen, Vesa; Viljanen, Tapio; Parkkola, Riitta; Scheinin, Harry

doi:10.1213/ane.0b013e31818ffc9d

Cited by 26 publications

(16 citation statements)

References 42 publications

(54 reference statements)

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“…This may result in inappropriate luxury perfusion, which should be avoided, particularly in pathological conditions where cerebral homeostasis is already compromised. In addition, increases in GMR caused by anaesthetics are considered harmful . A study compared the relative effects of sevoflurane and propofol anaesthesia on rGMR in humans.…”

mentioning

confidence: 99%

Regional cerebral blood flow and glucose metabolism during propofol anaesthesia in healthy subjects studied with positron emission tomography

Schlünzen

Juul

Hansen

et al. 2011

Acta Anaesthesiol Scand

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mentioning

confidence: 99%

Regional cerebral blood flow and glucose metabolism during propofol anaesthesia in healthy subjects studied with positron emission tomography

Schlünzen

Juul

Hansen

et al. 2011

Acta Anaesthesiol Scand

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“…This effect is in accordance with the knowledge that medetomidine causes no dose‐dependent insulin suppression and therefore increases glucose levels in dogs . Moreover, results from some human studies have suggested that the relationship between cerebral glucose metabolism and blood flow can be altered by some anesthetics . We have not found any reports examining medetomidine or butorphanol influence on cerebral glucose metabolism and blood flow coupling.…”

Section: Discussionmentioning

confidence: 56%

Cerebral Glucose Utilization Measured With High Resolution Positron Emission Tomography in Epileptic Finnish Spitz Dogs and Healthy Dogs

Viitmaa

Haaparanta‐Solin

Snellman

et al. 2014

Vet Radiology Ultrasound

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In human epileptic patients, changes in cerebral glucose utilization can be detected 2-deoxy-2-[(18) F] fluoro-D-glucose positron emission tomography (FDG-PET). The purpose of this prospective study was to determine whether epileptic dogs might show similar findings. Eleven Finnish Spitz dogs with focal idiopathic epilepsy and six healthy dogs were included. Dogs were examined using electroencephalography (EEG) and FDG-PET, with epileptic dogs being evaluated during the interictal period. Visual and semi-quantitative assessment methods of FDG-PET were compared and contrasted with EEG findings. Three independent observers, unaware of dog clinical status, detected FDG-PET uptake abnormalities in 9/11 epileptic (82%), and 4/8 healthy dogs (50%). Occipital cortex findings were significantly associated with epileptic status (P = 0.013). Epileptic dogs had significantly lower standardized uptake values (SUVs) in numerous cortical regions, the cerebellum, and the hippocampus compared to the control dogs. The lowest SUVs were found in the occipital lobe. White matter normalized and left-right asymmetry index values for all pairs of homologous regions did not differ between groups. Visual evaluation of the EEGs was less sensitive (36%) than FDG-PET. Both diagnostic tests were consensual and specific (100%) for occipital findings, but EEG had a lower sensitivity for detecting lateralized foci than FDG-PET. Findings supported the use of FDG-PET as a diagnostic test for dogs with suspected idiopathic epilepsy. Visual and semiquantitative analyses of FDG-PET scans provided complementary information. Findings also supported the theory that epileptogenesis may occur in multiple brain regions in Finnish Spitz dogs with idiopathic epilepsy.

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“…However, with exceptions beginning to emerge (26,27), such studies involve animals under general anesthesia. Anesthesia is well known to cause substantial fluctuations in radiotracer uptake through alterations in delivery (cerebral blood flow) and brain metabolism, suggesting that studies performed under anesthesia are only rough guides for the clinical studies to follow (23,28). Non-human primate studies are expensive, laborious, and not amenable to large sample sizes.…”

Section: Discussionmentioning

confidence: 99%

Molecular Imaging of Conscious, Unrestrained Mice with AwakeSPECT

et al. 2013

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We have developed a SPECT imaging system, AwakeSPECT, to enable molecular brain imaging of untrained mice that are conscious, unanesthetized, and unrestrained. We accomplished this with head tracking and motion correction techniques. Methods: The capability of the system for motion-corrected imaging was demonstrated with a 99mTc-pertechnetate phantom, 99mTcmethylene diphosphonate bone imaging, and measurement of the binding potential of the dopamine transporter radioligand 123I-ioflupane in mouse brain in the awake and anesthetized (isoflurane) states. Stress induced by imaging in the awake state was assessed through measurement of plasma corticosterone levels. Results: AwakeSPECT provided high-resolution bone images reminiscent of those obtained from CT. The binding potential of 123I-ioflupane in the awake state was on the order of 50% of that obtained with the animal under anesthesia, consistent with previous studies in nonhuman primates. Levels of stress induced were on the order of those seen in other behavioral tasks and imaging studies of awake animals. Conclusion: These results demonstrate the feasibility of SPECT molecular brain imaging of mice in the conscious, unrestrained state and demonstrate the effects of isoflurane anesthesia on radiotracer uptake.

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The Effects of Xenon Anesthesia on the Relationship Between Cerebral Glucose Metabolism and Blood Flow in Healthy Subjects: A Positron Emission Tomography Study

Cited by 26 publications

References 42 publications

Regional cerebral blood flow and glucose metabolism during propofol anaesthesia in healthy subjects studied with positron emission tomography

Regional cerebral blood flow and glucose metabolism during propofol anaesthesia in healthy subjects studied with positron emission tomography

Cerebral Glucose Utilization Measured With High Resolution Positron Emission Tomography in Epileptic Finnish Spitz Dogs and Healthy Dogs

Molecular Imaging of Conscious, Unrestrained Mice with AwakeSPECT

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