The efficacy and optimum time of administration of ranitidine in the prevention of the acid aspiration syndrome

Escolano, F.; Sierra, P. Alvarez de; Ortiz, Javier; Cabrera, Joanne; Castaño, Juan G.

doi:10.1111/j.1365-2044.1996.tb07711.x

Cited by 8 publications

(7 citation statements)

References 12 publications

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“…It is commonly used in treatment of peptic ulcer disease (PUD) and gastro esophageal reflux disease (GERD). It has been demonstrated that 150 mg of oral ranitidine when given two to three hours before surgery resulted in a mean gastric pH of 5.86 within 60 minutes (Escolano 1996). It has also been shown that there is no significant difference between 150 mg and 300 mg, with both taking around 60 minutes to achieve a sustained increase in pH which then lasts for approximately five hours.…”

Section: H 2 Receptor Antagonistsmentioning

confidence: 99%

Anesthesia for Cesarean Section

Capogna¹

2017

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Section: H 2 Receptor Antagonistsmentioning

confidence: 99%

Anesthesia for Cesarean Section

Capogna¹

2017

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“…A meta-analysis involving both obstetric and nonobstetric studies suggested that premedication with ranitidine was more effective than proton pump inhibitors in reducing the volume of gastric secretions and increasing gastric pH 46. Ranitidine should be administered at least 60 minutes if given orally and 30 minutes if given intravenously, prior to cesarean delivery for optimum effect on gastric volume and pH 47. However, there are no data to examine the association between reduced gastric acidity and the frequency of pulmonary aspiration, vomiting, morbidity, or mortality in obstetric patients who aspirate gastric contents 48.…”

Section: Technical Considerationsmentioning

confidence: 99%

Managing anesthesia  for cesarean section in obese patients: current perspectives

Lamon¹,

Habib²

2016

LRA

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Obesity is a worldwide epidemic. It is associated with increased comorbidities and increased maternal, fetal, and neonatal complications. The risk of cesarean delivery is also increased in obese parturients. Anesthetic management of the obese parturient is challenging and requires adequate planning. Therefore, those patients should be referred to antenatal anesthetic consultation. Anesthesia-related complications and maternal mortality are increased in this patient population. The risk of difficult intubation is increased in obese patients. Neuraxial techniques are the preferred anesthetic techniques for cesarean delivery in obese parturients but can be technically challenging. An existing labor epidural catheter can be topped up for cesarean delivery. In patients who do not have a well-functioning labor epidural, a combined spinal epidural technique might be preferred over a single-shot spinal technique since it is technically easier in obese parturients and allows for extending the duration of the block as required. A continuous spinal technique can also be considered. Studies suggest that there is no need to reduce the dose of spinal bupivacaine in the obese parturient, but there is little data about spinal dosing in super obese parturients. Intraoperatively, patients should be placed in a ramped position, with close monitoring of ventilation and hemodynamic status. Adequate postoperative analgesia is crucial to allow for early mobilization. This can be achieved using a multimodal regimen incorporating neuraxial morphine (with appropriate observations) with scheduled nonsteroidal anti-inflammatory drugs and acetaminophen. Thromboprophylaxis is also important in this patient population due to the increased risk of thromboembolic complications. These patients should be monitored carefully in the postoperative period, since there is increased risk of postoperative complications in the morbidly obese parturients.

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“…The preoperative administration of histamine H 2 RAs decreases the risk of complications from aspiration following surgery [60, 61]. Intravenous PPIs have also shown promise when used in this setting.…”

Section: Potential Uses For IV Ppismentioning

confidence: 99%

Potential Uses of Intravenous Proton Pump Inhibitors to Control Gastric Acid Secretion

Metz¹

2000

Digestion

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Proton pump inhibitors are the most effective agents for suppressing gastric acidity and are the preferred therapy for many acid-related conditions. While proton pump inhibitors have been accessible in intravenous formulations in several European countries, they have been available only as oral drugs in the United States. In the near future, the proton pump inhibitor pantoprazole is likely to become available in an intravenous formulation for American patients. Potential uses for intravenous proton pump inhibitors include treatment of Zollinger-Ellison syndrome and peptic ulcers complicated by bleeding or gastric outlet obstruction, as well as prevention of stress ulcers and acid-induced lung injury. These intravenous proton pump inhibitors are also likely to be beneficial to patients undergoing long-term maintenance with oral proton pump inhibitors who cannot take oral therapy for a period of time. Intravenous pantoprazole is especially distinguished in its lack of clinically relevant drug interactions, and it requires no dosage adjustment for patients with renal insufficiency or with mild to moderate hepatic dysfunction. Both omeprazole and pantoprazole are well tolerated in both oral and intravenous forms. Although further studies are needed to define their roles clearly, the availability of intravenous formulations of proton pump inhibitors will certainly assist with the treatment of gastric acid-related disorders.

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The efficacy and optimum time of administration of ranitidine in the prevention of the acid aspiration syndrome

Abstract: Summary In order to evaluate the eficacy o f a single oral dose of ranitidine

Cited by 8 publications

References 12 publications

Anesthesia for Cesarean Section

Anesthesia for Cesarean Section

Managing anesthesia  for cesarean section in obese patients: current perspectives

Potential Uses of Intravenous Proton Pump Inhibitors to Control Gastric Acid Secretion

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The efficacy and optimum time of administration of ranitidine in the prevention of the acid aspiration syndrome

Abstract: Summary In order to evaluate the eficacy o f a single oral dose of ranitidine

Cited by 8 publications

References 12 publications

Anesthesia for Cesarean Section

Anesthesia for Cesarean Section

Managing anesthesia &nbsp;for cesarean section in obese patients: current perspectives

Potential Uses of Intravenous Proton Pump Inhibitors to Control Gastric Acid Secretion

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Managing anesthesia for cesarean section in obese patients: current perspectives