The Efficacy and Psychoneuroimmunology Mechanism of Camouflage Combined With Psychotherapy in Vitiligo Treatment

Chang, Yi‐Lu; Zhang, Shaolong; Zhang, Weigang; Li, Shuli; Li, Chunying

doi:10.3389/fmed.2022.818543

Cited by 3 publications

(3 citation statements)

References 56 publications

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“…Sunscreens with color correction may help camouflage white areas of vitiligo and this may improve quality of life, 12,91 possibly by modulating the psycho-neuro-endocrineimmuno-skin system. 92 Actinic lentigo Pigmented spots are more prominent and earlier sign of skin aging in Asian populations than in Europeans. [93][94][95] The use of a broad-spectrum UVB/UVA-VL sunscreen (containing pigments) for 60 days significantly decreased the hyperpigmented area of actinic lentigo compared to the use of sunscreens containing only UV filters.…”

Section: Melasmamentioning

confidence: 99%

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Awareness of sun exposure risks and photoprotection for preventing pigmentary disorders in Asian populations: Survey results from three Asian countries and expert panel recommendations

Goh,

Kang,

Morita

et al. 2023

Photoderm Photoimm Photomed

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BackgroundIn this article, we review and discuss the photoprotection behavior of Asians based on the literature, along with a subanalysis of an original online survey, and make recommendations to optimize photoprotection for Asian populations to prevent photoaging and pigmentary disorders.MethodsAn international panel of eight dermatologists from Asia (China, Korea, Japan, Singapore, Indonesia, and Vietnam) met to discuss sunscreen photoprotection for Asian patients. Additionally, a subanalysis of an online survey by 3000 respondents from three Asian countries (China, Indonesia, and Japan) investigated general public awareness and attitudes to sun exposure.ResultsA pre‐meeting survey of the eight experts from Asia showed key concerns of Asian patients consulting dermatologists are pigmentary disorders, especially actinic/senile lentigo, post‐inflammatory hyperpigmentation, melasma, vitiligo, and Hori's nevus. The survey subanalysis of participants from China, Indonesia, and Japan with predominantly Fitzpatrick skin types (FST) II to IV revealed that they are particularly concerned about sun exposure causing photoaging and pigmentary disorders. Most of the respondents indicated they have limited knowledge on sunlight radiation and appropriate sunscreen protection factors. Only 22%, 13%, and 3% for China, Indonesia, and Japan, respectively, systematically use multiple protective measures (using sunscreen, avoiding midday sun, staying in the shade, wearing a hat, protective clothing, and sunglasses) when exposed to the sun.ConclusionsFurther education is needed for Asian populations on the importance of comprehensive daily photoprotection, including broad‐spectrum sunscreen, with high UVA and visible light protection, to reduce and prevent photoaging and pigmentary disorders.

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Section: Melasmamentioning

confidence: 99%

“…Sunscreens with color correction may help camouflage white areas of vitiligo and this may improve quality of life, 12,91 possibly by modulating the psycho‐neuro‐endocrine‐immuno‐skin system 92 …”

Section: Broad‐spectrum Photoprotection Recommendations To Prevent Ph...mentioning

confidence: 99%

Awareness of sun exposure risks and photoprotection for preventing pigmentary disorders in Asian populations: Survey results from three Asian countries and expert panel recommendations

Goh,

Kang,

Morita

et al. 2023

Photoderm Photoimm Photomed

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“…Cytokines play a crucial role in facilitating cellular communication and networking [7]. The secretion of multiple cytokines by these T cells can result in melanocyte destruction, either through direct mechanisms or by activating autoreactive T cells in vitiligo [8][9][10]. Furthermore, chemo-attractant cytokines play a pivotal role in recruiting leukocytes to inflammatory sites, amplifying the inflammatory reaction, and inducing melanocyte death [11].…”

Section: Introductionmentioning

confidence: 99%

Serum cytokine profiles predict response to systemic glucocorticoid in active vitiligo

Wang,

Fan,

et al. 2024

pdia

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Introduction Vitiligo is an immune-related skin disease. Cytokines regulate immune response and inflammation and are involved in the pathogenesis of vitiligo. Aim To assess the serum levels of pro-inflammatory cytokines pre- and post- systemic glucocorticoid treatment in patients with active vitiligo. Material and methods We measured serum cytokine levels using the enzyme-linked immunosorbent assay in 31 patients with active vitiligo before and after treatment. All patients received systemic glucocorticoid (compound betamethasone injection) in combination with topical halometasone cream and tacrolimus ointment for 3 months. Twenty healthy controls were also examined. The cytokines measured included TNF-α, IL-1β, IL-6, IFN-γ, IL-2, IL-17, IL-10, IL-8, and CXCL10. Results The serum levels of TNF-α, IL-1β, IL-6, IFN-γ, IL-2, IL-17, IL-8, and CXCL10 were significantly higher, and levels of IL-10 were lower in vitiligo patients compared to controls. Additionally, serum IFN-γ ( r = 0.378; p = 0.036), IL-17 ( r = 0.426; p = 0.017), and CXCL10 ( r = 0.514; p = 0.003) showed a positive correlation with affected body surface area in vitiligo patients. After 3 months of systemic glucocorticoid treatment, the levels of IL-1β, IFN-γ, IL-2, IL-17, and CXCL10 in responders were significantly decreased and nearly restored to normal levels. The IL-10 level was also increased in response to treatment. In contrast, the non-responder group had persistently high IL-6, IL-17, IL-8, and CXCL10 levels, and negligible changes in TNF-α, IL-1β, IFN-γ, IL-2, and IL-10. Conclusions Our study indicated that the levels of inflammatory cytokines were significantly ameliorated in the glucocorticoid responder group. Altered cell-mediated immunity may contribute to the resistance in vitiligo. The cytokines such as TNF-α, IL-1β, IFN-γ and IL-2 could serve as therapeutic targets for managing glucocorticoid-resistant vitiligo.

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Review of modern methods of treating vitiligo

Bazhenova,

Kruglova

2024

Medicinskij alfavit

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The Efficacy and Psychoneuroimmunology Mechanism of Camouflage Combined With Psychotherapy in Vitiligo Treatment

Cited by 3 publications

References 56 publications

Awareness of sun exposure risks and photoprotection for preventing pigmentary disorders in Asian populations: Survey results from three Asian countries and expert panel recommendations

Awareness of sun exposure risks and photoprotection for preventing pigmentary disorders in Asian populations: Survey results from three Asian countries and expert panel recommendations

Serum cytokine profiles predict response to systemic glucocorticoid in active vitiligo

Review of modern methods of treating vitiligo

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