The efficacy and safety of mitomycin C intra urethral injection to prevent recurrent urethral stricture: A systematic review and meta-analysis

Pranata, Firmantya Hadi; Hidayatullah, Furqan; Kloping, Yudhistira Pradnyan; Rahman, Zakaria Aulia; Rizaldi, Fikri; Soebadi, Doddy M

doi:10.1016/j.amsu.2022.103576

Cited by 4 publications

(4 citation statements)

References 32 publications

(28 reference statements)

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“…The presence of these growth factors and the benefits of adding a free peritoneal patch to colonic anastomoses can be taken into consideration for further research. Several studies also reported increased fibroblast proliferation is associated with overexpression of extracellular matrix and Connective Tissue Growth Factor (CTGF) (Pranata FH et al, 2022)…”

Section: Comparison Of Bursting Pressure Anastomosismentioning

confidence: 99%

effect of a free peritoneal patch on bursting pressure in primary colonic anastomosis with intraperitoneal infection conditions

Kusuma

Hariastawa

Matulatan

2022

ijhs

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Anastomotic leakage following colorectal resection is reported to have a significant mortality and morbidity. Various surgical technologies have been developed to improve the outcome of colonic anastomotic, including biomaterial protective agent which has limitations in expensive price and rejection risk. The free peritoneal graft contains growth factors, antimicrobial agent and progenitor or stem cell nature by Mesothelial-Mesenchymal transition mechanism for wound healing process. Examining the healing of colonic anastomotic treated with free peritoneal graft in the presence of intraperitoneal infection by measuring the bursting pressure of the colonic tissue after surgery. We conducted an experimental study using 30 fecal peritonitis-induced New Zealand White Rabbit in 2 sample groups. Both of them have half circumferential diameter colonic resection treated with primary anastomotic using 5/0 silk braided suture material. In the treatment group, free peritoneal auto-graft was harvested and applicated. Bursting pressure was measured on the colonic tissue treated with anastomosis on day-7. The changes in the rabbits’ body weight before and after surgery which describe the nutritional status did not significantly affect the bursting pressure value (P = 0.745).

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Section: Comparison Of Bursting Pressure Anastomosismentioning

confidence: 99%

effect of a free peritoneal patch on bursting pressure in primary colonic anastomosis with intraperitoneal infection conditions

Kusuma

Hariastawa

Matulatan

2022

ijhs

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“…[2][3][4] Multiple alternatives have been proposed to urethroplasty in the setting of recurrent stricture, including mechanical stents and injectable agents. [5][6][7] Officially approved by the FDA in December 2021, the Optilume ® drug-coated balloon (DCB) (Urotronic, Plymouth, MN) provides a new alternative for men who do not wish to repeat standard endoscopic management but are also not interested in urethroplasty.…”

Section: Introductionmentioning

confidence: 99%

“…Even so, most urologists do not perform urethroplasty and are more likely to undertake endoscopic management despite literature confirming the superiority of the former 2–4 . Multiple alternatives have been proposed to urethroplasty in the setting of recurrent stricture, including mechanical stents and injectable agents 5–7 …”

Section: Introductionmentioning

confidence: 99%

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Optilume drug‐coated balloon for anterior urethral stricture: 2‐year results of the ROBUST III trial

VanDyke,

Morey,

Coutinho

et al. 2023

BJUI Compass

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ObjectiveThe aim of this study is to report the updated 2‐year results of the intervention arm of the ROBUST III randomized trial evaluating the safety and efficacy of the Optilume drug‐coated balloon (DCB) versus standard endoscopic management of recurrent male anterior urethral stricture.Materials and MethodsEligible patients included men with recurrent anterior urethral stricture ≤3 cm in length and ≤12Fr in diameter, International Prostate Symptom Score (IPSS) ≥11 and peak flow rate (Qmax) <15 mL/s. Patients were randomized to treatment with the Optilume DCB or standard‐of‐care endoscopic management. Primary efficacy endpoints measured at 2 years included freedom from re‐intervention and changes in IPSS, Qmax and post‐void residual (PVR). Secondary endpoint was impact on sexual function using the International Index of Erectile Function (IIEF). Primary safety endpoint was freedom from serious procedure‐ or device‐related adverse events (AEs).ResultsA total of 127 patients enrolled at 22 sites in the United States and Canada (48 randomized to standard‐of‐care dilation and 79 to DCB dilation). Seventy‐five patients in the DCB arm entered the open‐label phase after 6 months. Participants averaged 3.2 prior endoscopic interventions (range 2–10); most (89.9%) had bulbar strictures with an average stricture length of 1.63 cm (SD 0.76). Significant improvements in IPSS, average Qmax and PVR were maintained at 2 years. Freedom from repeat intervention was significantly higher in the Optilume DCB arm at 2 years versus the Control arm at 1 year (77.8% vs. 23.6%, p < 0.001). During the follow‐up period, there were 15 treatment failures and two non‐study‐related deaths. Treatment‐related AEs were rare and generally self‐limited (haematuria, dysuria and urinary tract infection).ConclusionThe Optilume DCB shows sustained improvement in both objective and subjective voiding parameters at 2‐year follow‐up. Optilume appears to provide a safe and effective endoscopic treatment alternative for short recurrent anterior urethral strictures among men who wish to avoid or delay formal urethroplasty.

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Na+,K+-atpase as a target of the antiproliferative effect of mitomycin C in the treatment of urethral stricture

SHEREMETA,

VOROBETS

2023

Eksp.Klin.fiziol.biohim

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The efficacy and safety of mitomycin C intra urethral injection to prevent recurrent urethral stricture: A systematic review and meta-analysis

Cited by 4 publications

References 32 publications

effect of a free peritoneal patch on bursting pressure in primary colonic anastomosis with intraperitoneal infection conditions

effect of a free peritoneal patch on bursting pressure in primary colonic anastomosis with intraperitoneal infection conditions

Optilume drug‐coated balloon for anterior urethral stricture: 2‐year results of the ROBUST III trial

Na+,K+-atpase as a target of the antiproliferative effect of mitomycin C in the treatment of urethral stricture

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