The efficacy and safety of massage adjuvant therapy in the treatment of diabetic peripheral neuropathy

Abstract

BackgroundThe incidence of diabetic peripheral neuropathy (DPN) is increasing year by year. If patients cannot receive timely and effective treatment, DPN may lead to diabetic foot ulcers or even amputation. This risk factor has been widely concerned around the world. Massage, as a non-invasive physical therapy method, is gradually being applied in the adjuvant treatment of DPN. However, there is no systematic review of the adjuvant treatment of DPN by massage. Our study will explore the effectiveness and safety of massage applied in DPN.MethodsEight electronic databases (PubMed, Cochrane, Web of Science, Sinomed, Embase, China National Knowledge Infrastructure, WanFang Data, Chongqing VIP Information) will be searched by our computer on February 9, 2022. A randomized controlled trial (RCT) of adjuvant massage therapy for DPN was screened. Primary outcome measures: efficiency, nerve conduction velocity. Secondary outcome measures: pain, blood glucose, and incidence of adverse reactions. The quality of the study was evaluated by two researchers using the RCT bias risk assessment tool in the Cochrane review manual Handbook5.4, and meta-analysis was performed by RevMan5.4 software.ResultsRCTs will be used to evaluate the clinical efficacy of massage adjuvant therapy in DPN.ConclusionThis study will provide evidence-based evidence for the safety and effectiveness of massage adjuvant therapy in DPN.Protocol registration number:INPLASY202220025.

Effect of miR-146a polymorphism on lipoic acid therapy in patients with T2DM peripheral polyneuropthy

“…However, this treatment plan can only alleviate clinical symptoms and signs, and has lower significance in improving the condition. Zinc sulfate, as a coenzyme, exists in the mitochondrial enzyme and can be biotransformation into reduced dihydrogen sulfate (18). The application of sufficient doses of zinc sulfate can effectively eliminate free radicals and chelated metal ions in the body, enabling them to generate other antioxidants and have significant antioxidant effects.…”

"Effectiveness of Acupoint Massage for Improving Sensory Function of Peripheral Nerve in Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis"

“…A total of 9 studies did not use acupoint massage alone, and 7 studies lacked the outcome measure, total effectiveness, or SCV, or TCSS. At the end of the selection process, 20 studies met the inclusion criteria (Figure 1) [26][27][28][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49] After assessing the Cochrane tool ROB-2, the condition of studies quality came out. (Figure 2) displays the overall quality of studies, which showed approximately 22.2% low risk, 66.7% some concerns and 11.1% high risk of Overall bias.…”

“…As shown in Figure 3, we saw that some studies had several items of high risk. Comparatively, Tian [42] and Zhu [39] got a bad performance on bias of deviations from intended interventions, which rarely displayed information about intervention [39][40][41][42] and Zhang [43] got a good grade which owned four low risk of bias, while Liang [48] and Huang [26] only had two low-risk items [26,28,43].…”

“…The disease duration in all included studies was no more than 20 years, but Lin et al and Wang Wei et al did not display patients' duration of disease [40,46]. Zhang [43] had the shortest duration of disease, in which experimental group was 1.42±0.34 years while control group was 1.51±0.38 years [42]. Zhou et al had the longest duration, in which experimental group was 20.08±3.14 years while control group was 20.17±3.32 years [36].…”

Improving Effects of Peripheral Nerve Decompression Microsurgery of Lower Limbs in Patients with Diabetic Peripheral Neuropathy

“…Other methods have also been reported such as the consumption of antioxidants, supplementation of nerve growth factors, and the administration of immunosuppressants [ 10 , 11 ]. However, there is currently no specific and satisfactory therapeutic method in clinical practice [ 12 ]. Professor Dellon found that the sensitivity of peripheral nerves to compression increased during diabetes, and demonstrated that the symptoms of DPN were caused by nerve compression, and after taking the lead in the treatment of DPN with peripheral nerve decompression microsurgery, the surgery was effective, and the course of DPN changed [ 13 ].…”