The Efficacy and Safety of Chinese Herbal Decoction in Type 2 Diabetes: A 5‐Year Retrospective Study

Abstract

Background. The study was designed to assess the efficacy and safety of Chinese herbal decoction in treating outpatients with T2DM. Methods. All patients enrolled received decoction for at least 6 months. The primary outcome was the control rate of HbA1c and the change in HbA1c. FPG, 2hPG, HOMA-IR, and HOMA-β were also collected and evaluated. Results. The control rates after treatment at months 6, 12, 18, 24, 36, 48, and 60 were 45.07%, 52.78%, 47.22%, 45.83%, 50.00%, 57.14%, and 40.00%. Multiple linear regression showed the change of HbA1c has a significant relationship with the baseline HbA1c and duration of DM and BMI (p < 0.05). Both FPG and 2hPG levels significantly decreased compared to the baseline (p < 0.05). Chinese herbal decoction also improved islet cell function with decreased HOMA-IR and increased HOMA-β (p < 0.05). 19 and 4 subjects deactivated the antidiabetes drugs or insulin, respectively, after taking decoction. One subject developed DKD and one developed DPN, and another subject showed abnormal liver function which was irrelevant to decoction treatment. Conclusions. Chinese herbal decoction significantly enhanced the hypoglycemic action and had certain effect on protecting islet cell function. As a candidate diabetes therapy, it may reduce the use of antidiabetes drugs and slow the progression to diabetes complications.

Gegen Qinlian Decoction Coordinately Regulates PPARγ and PPARα to Improve Glucose and Lipid Homeostasis in Diabetic Rats and Insulin Resistance 3T3-L1 Adipocytes

“…Gegen Qinlian Decoction (GQD), a well-documented traditional TCM formula, was used for treating diarrhea and dysentery for a long time. Recently, GQD was effective and safe in glycemic control with increased insulin sensitivity for patients in a randomized double blind placebo controlled clinical trial and a 5-year retrospective study (Xu et al, 2015;Tian et al, 2016). However, the precise anti-diabetic mechanism of GQD remains unknown.…”

Chinese herbal medicine Tangshen Formula Treatment For Type 2 Diabetic Kidney Disease in Early Stage : study protocol for a randomized controlled trial

“…It is urgent to seek an effective preventive measure to delay DKD. CHMs have been common in treating DM [37][38][39][40][41][42]and its complications [43][44][45], including DKD. In modern times, Many patients have turned to Chinese herbal medicine for treatment as a complementary and basic combinationdrug therapy for kidney disease in China due to its fewer adverse reactions and more effective interventions.…”

Chinese herbal medicine Tangshen Formula Treatment For Type 2 Diabetic Kidney Disease in Early Stage : study protocol for a randomized controlled trial

“…It is urgent to seek an effective preventive measure to delay DKD. CHMs have been common in treating DM [37][38][39][40][41][42]and its complications [43][44][45], including DKD. In modern times, many patients have turned to Chinese herbal medicine for treatment as a complementary and necessary combination-drug therapy for kidney disease in China due to its fewer adverse reactions and more effective interventions.…”