The efficacy of a traditional medicine preparation on second-degree burn wounds in rats

Ebrahimpour, Nasser; Mehrabani, Mehrnaz; Iranpour, Maryam; Kordestani, Zeinab; Mehrabani, Mitra; Nematollahi, Mohammad Hadi; Asadipour, Ali; Raeiszadeh, Mahboobeh; Mehrbani, Mehrzad

doi:10.1016/j.jep.2020.112570

Cited by 18 publications

(9 citation statements)

References 59 publications

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“…Furthermore, we found that the size of the burn wounds was increased in all experimental groups except the blank control group on day 3 after burn injury. Some previous studies have reported similar observations; the size increase may be related to low perfusion, microthrombosis, autophagy-induced cytokine activity and tissue degradation, which cause the edges of ulcers to expand [ 21 , 22 ]. Beginning on day 7, the wound area in the treatment groups was significantly smaller than that in the MD group.…”

Section: Discussionmentioning

confidence: 57%

Effects of ginsenoside Rb1 on second-degree burn wound healing and FGF-2/PDGF-BB/PDGFR-β pathway modulation

Zhang

Jin

et al. 2021

Chin Med

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Background Panax notoginseng (Burk.) F. H. Chen (P. notoginseng) is a traditional Chinese medicine that has been used therapeutically for cardiovascular diseases, inflammatory diseases and traumatic injuries as well as for external and internal bleeding due to injury. Ginsenoside Rb1, a crucial monomeric active constituent extracted from P. notoginseng, has attracted widespread attention because of its potential anti-inflammatory, bacteriostatic, and cell growth-promoting effects. In this study, the therapeutic effects of ginsenoside Rb1 on second-degree burn in rats and the potential underlying mechanisms were explored. Methods A rat model of second-degree burn injury was established, and skin wound healing was monitored at different time points after ginsenoside Rb1 treatment. HE staining was performed to identify burn severity, and biological tissues were biopsied on days 0, 7, 14, and 24 after treatment. Skin wound healing at different time points was monitored by macroscopic observation. Furthermore, IHC, WB, and RT-PCR were utilized to determine the protein and mRNA expression levels of PDGF-BB, PDGFR-β, and FGF-2 in wound tissues after treatment. Results HE staining showed that after 24 days of ginsenoside Rb1 treatment, skin tissue morphology was significant improved. Macroscopic observation demonstrated that in ginsenoside Rb1-treated rats, the scab removal time and fur growth time were decreased, and the wound healing rate was increased. Collectively, the results of IHC, WB and RT-PCR showed that PDGF-BB, PDGFR-β, and FGF-2 expressions peaked earlier in ginsenoside Rb1-treated rats than in model rats, consistent with the macroscopic observations. Conclusion Collectively, these findings indicated that ginsenoside Rb1 promotes burn wound healing via a mechanism possibly associated with upregulation of FGF-2/PDGF-BB/PDGFR-β gene and protein expressions.

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Section: Discussionmentioning

confidence: 57%

Effects of ginsenoside Rb1 on second-degree burn wound healing and FGF-2/PDGF-BB/PDGFR-β pathway modulation

Zhang

Jin

et al. 2021

Chin Med

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“…In this study, we have added sesame oil and olive oil to the above-mentioned composite to make a new composite that can be useful in the treatment of skin burns. Sesame oil is rich in many biological active ingredients especially β-sitosterol [ 7 , 8 , 37 , 51 ], which is the active ingredient of a commercially available cream (MEBO ® -cream). Additionally, olive oil has been used in various previous studies investigating its role in the wound healing process [ 8 , 43 , 52 , 53 ].…”

Section: Discussionmentioning

confidence: 99%

“…Chamomile possesses antioxidant and anti-inflammatory properties in addition to its role in skin protection and regeneration of the necrosed skin [ 30 , 31 , 32 , 33 , 34 , 35 , 36 ]. Other oils of plant origin such as sesame oil [ 22 , 37 , 38 ] and olive oil [ 38 , 39 ] have been subjected to several experimental studies to evaluate their effects on the healing process of skin burns. Sesame oil is considered one of the most important sources of β-sitosterol which is one of the most powerful natural anti-inflammatory [ 7 , 40 ] which used to prevent and treat tissue necrosis [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

Histopathological Evaluation of the Healing Process of Standardized Skin Burns in Rabbits: Assessment of a Natural Product with Honey and Essential Oils

Anis

Sharshar

Hanbally

et al. 2022

JCM

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Skin burns are one of the most difficult medical problems. Recently, studies have been directed towards development of natural products in order to identify effective and safe remedies. In the present study, we evaluated the efficacy of a natural composite (formulated from honey and essential oils) compared with MEBO® (0.25% β-sitosterol) and DERMAZIN® creams (1% silver-sulfadiazine) in the treatment of thermally induced skin burns. For this purpose, four burn-wounds were created on the back of male New Zealand rabbits (n = 10) using a thermal stamp under the effect of general anesthesia. Each wound represents one of the following groups: non-treated, natural composite-cream, MEBO®-cream, and silver-sulfadiazine treated groups, respectively. Treatments were applied once a day topically until one of these wounds appeared to be healed grossly. The non-treated group received no treatment. Grossly, skin burns have been healed after 28 days of the treatment in all groups except of the non-treated group. The healing efficacy of the natural composite, MEBO® and silver-sulfadiazine creams was quite similar macroscopically. However, microscopically, the epidermal layer of the composite-cream treated group was more mature than those of both MEBO® and silver-sulfadiazine creams treated groups. In conclusion, the tested composite may be a promising effective and inexpensive treatment of skin burns.

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“…In 2020, Ebrahimpour et al similarly conducted an animal study evaluating the efficacy of a beeswax-containing substance on burns. 19 They assessed the wound closure rate and neovascularization of second-degree burn wounds in rats following the application of Lime Salve (LS), a mixture containing calcium hydroxide powder, beeswax, and sesame oil. In comparison with the control group receiving normal saline, they found that LS increased wound closure rate and neovascularization on Day 10, in addition to collagen formation on Days 17 and 24.…”

Section: Uses In Burnsmentioning

confidence: 99%

A review of the use of beeswax in skincare

Nong¹,

Maloh²,

Natarelli

et al. 2023

J of Cosmetic Dermatology

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Background Beeswax is a naturally occurring product secreted from worker bees that has varied uses in modern day. In skincare, its function ranges from its role as an occlusive, helping to create a semi‐occlusive skin barrier that minimizes transepidermal water loss; as a humectant, locking in hydration; and an emollient to soften and soothe the skin. As a natural substance, its use has been shown to help alleviate symptoms associated with common cutaneous conditions like dermatitis, psoriasis, and overgrowth of normal skin flora. Aims In this narrative review, we aim to describe current uses of beeswax in skincare that has been published in the literature. Materials and methods A review of beeswax related publications was performed by searching the PubMed database studies. Results A total of five clinical studies were included with three studies on animals and two studies in humans. Discussion Several studies show the benefits of topical beeswax in supporting the skin barrier. Conclusion Beeswax can be a low‐cost, natural ingredient for use in products. Further studies with topical beeswax are warranted.

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The efficacy of a traditional medicine preparation on second-degree burn wounds in rats

Cited by 18 publications

References 59 publications

Effects of ginsenoside Rb1 on second-degree burn wound healing and FGF-2/PDGF-BB/PDGFR-β pathway modulation

Effects of ginsenoside Rb1 on second-degree burn wound healing and FGF-2/PDGF-BB/PDGFR-β pathway modulation

Histopathological Evaluation of the Healing Process of Standardized Skin Burns in Rabbits: Assessment of a Natural Product with Honey and Essential Oils

A review of the use of beeswax in skincare

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