The efficacy of add-ons: selected IVF “add-on” procedures and future directions

Glatthorn, Haley N.; DeCherney, Alan H.

doi:10.1007/s10815-022-02410-6

Cited by 14 publications

(5 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is expected to increase the number of cases in which HETM is used in the future regardless of the condition of the embryo or endometrium. However, some add-ons in IVF treatment lack medical evidence and are undesirable from the perspective of cost-effectiveness [ 17 ]; there are reports that the use of HETM is also effective in improving implantation and pregnancy rates as well as reports that it is not effective, and thus further large-scale surveys are needed. It will be necessary to select cases in which HETM should be used with consideration of cost-effectiveness.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Hyaluronan-Enriched Transfer Medium for Low-Grade Frozen Embryo Transfer

Homma¹,

Yanaihara²,

Hatakeyama³

et al. 2023

Cureus

View full text Add to dashboard Cite

Research question: This study aimed to retrospectively evaluate the efficacy of a hyaluronan-enriched transfer medium (HETM) for transfer failures and transfer of frozen embryos that have been graded as C at the time of transfer according to the Gardner classification of trophectoderm (TE). Design: This study included 365 cycles of unsuccessful frozen-thawed embryo transfers in hormone replacement cycles graded C according to the Gardner classification of TE at the time of transfer. Clinical pregnancy rates were compared using the χ 2 test, with the patients divided into two groups: one whose transfers did include HETM (HETM group) and one whose transfers did not include HETM (control group). As a subgroup analysis, patients with a TE grade of C at the time of transplantation were divided into two groups: those aged 39 years or younger and those aged 40 years or older at the time of transplantation. The clinical pregnancy rates of the groups with and without HETM were then compared. Results: No difference in the clinical pregnancy rates between the HETM and control groups was observed. Conclusions: Hyaluronic acid is believed to favor implantation by promoting adhesion between the embryo and the endometrium, and there are reports of improved implantation and pregnancy rates as a result of HETM. However, the present results suggest limited effectiveness for HETM. Further case series should be conducted, and the suitability of its use as a treatment should be investigated.

show abstract

Section: Discussionmentioning

confidence: 99%

Efficacy of Hyaluronan-Enriched Transfer Medium for Low-Grade Frozen Embryo Transfer

Homma¹,

Yanaihara²,

Hatakeyama³

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

“…M a n u s c r i p t a c c e p t e d f o r p u b l i c a t i o n and are widely believed to be safe and effective, the scientific evidence supporting these techniques is either strongly contradictory or, at best, unclear. From these innovations, aiming not to reach RIF, are endometrial scratching, assisted hatching, embryo glue and elective freeze all cycles [7].…”

Section: Introductionmentioning

confidence: 99%

Impact of granulocyte colony stimulating factor infusion on the implantation rate in women with unexplained previous intracytoplasmic sperm injection failure: a case control study

elmohamady¹,

Salama²,

Okasha³

2024

Ital J Gynaecol Obstet

View full text Add to dashboard Cite

Objective. We studied the G-CSF's effect on women with unexplained infertility and previous ICSI failure. Unexplained infertility is a condition when couples are not able to conceive despite normal semen analysis and absence of female infertility factor(s). Cytokines, transcription factors and signaling pathways are essential for complex interactions of decidualization. G-CSF is a glycoprotein with growth factor and cytokine functions, which are produced in many tissues.Patient and Methods. The study was done on a total of 200 women with only 196 women who ended the study (99 women as a study group, 96 women as a control group). All women were M a n u s c r i p t a c c e p t e d f o r p u b l i c a t i o n complaining of unexplained infertility with previous history of failed ICSI. All cases proceed through ICSI procedure while study group only undergone G-CSF infusion intrauterine at time of ovum pickup.Results. We found that intrauterine G-CSF injection at time of ovum pickup in the study group, in comparison with control group, did not improve neither implantation rate (16.68% vs 19.66%, p = 0.243) nor the chemical (54.5% vs 67%, p = 0.074), clinical pregnancy (51.5% vs 62.9%, p = 0.108) rates as well as live birth rates (31.0% vs 39.8%, p = 0.227). Conclusions.Intrauterine infusion of G-CSF may not improve Implantation rate in women with unexplained previous intracytoplasmic sperm injection (ICSI) failure. Further studies are needed to conclude if the dose, route and timing of the drug administration can give better results.

show abstract

“…There has been a lack of research specifically focusing on the psychological distress that arises from the treatments used for infertility. Since the early days of IVF, optimising ART procedures to maximise efficacy and success of treatment have received attention 7 ; nevertheless, psychological stress brought on by various ART treatment techniques has received less attention. While there has been research examining the impact of sex steroids on the neurological process in both genders, regardless of their mental diseases, 8 there is a lack of comprehensive reviews that have specifically investigated the effects of hormonal therapies for infertility on mental health in women.…”

Section: Introductionmentioning

confidence: 99%

The Psychological Effects of Hormonal Treatment on Women Under IVF Treatment: A Comprehensive Review

Vasudevan,

Bhuvaneswari

2024

Natl J Community Med

View full text Add to dashboard Cite

This comprehensive review delves into the intricate world of assisted reproductive technologies (ART) and hormonal treatments, exploring their profound psychological effects on women undergoing IVF treatment. The psychological distress of infertility, combined with the demanding nature of ART, has been widely acknowledged, yet a comprehensive examination of the psychological impacts has remained elusive. This study examined the psychological repercussions of hormonal medications used in IVF, addressing the complex interplay of hormones and their effects in each stage of the IVF process. This review followed PRISMA guidelines and included studies from PubMed, Google Scholar, and ScienceDirect. A total of nine papers were collected. The findings of this study identified that depression, anxiety, mood swings, irritability, sleep disturbances, and cognitive changes were the most commonly seen medically induced psychological effects among the IVF patients. This review offers a holistic understanding of the psychological intricacies of IVF treatment, highlighting the imperative need for a more comprehensive approach to address the emotional wellbeing of individuals undergoing fertility procedures.

show abstract

The efficacy of add-ons: selected IVF “add-on” procedures and future directions

Cited by 14 publications

References 64 publications

Efficacy of Hyaluronan-Enriched Transfer Medium for Low-Grade Frozen Embryo Transfer

Efficacy of Hyaluronan-Enriched Transfer Medium for Low-Grade Frozen Embryo Transfer

Impact of granulocyte colony stimulating factor infusion on the implantation rate in women with unexplained previous intracytoplasmic sperm injection failure: a case control study

The Psychological Effects of Hormonal Treatment on Women Under IVF Treatment: A Comprehensive Review

Contact Info

Product

Resources

About