The efficacy of chlorhexidine dentifrice or gel on plaque, clinical parameters of gingival inflammation and tooth discoloration: a systematic review

Slot, Dagmar Else; Berchier, C.E.; Addy, M.; Velden, U. van der; Weijden, G.A. van der

doi:10.1111/idh.12050

Cited by 59 publications

(61 citation statements)

References 55 publications

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“…During the last decade, various antimicrobials such as chlorhexidine, azithromycin, metronidazole, doxycycline, minocycline and tetracycline used subgingivally in conjunction with SRP have been tested [7]. Among the supragingivally used antiseptics, chlorhexidine based dentifrices/gels are still being the gold standard although tooth surface discoloration is observed as side effect [8].…”

Section: Introductionmentioning

confidence: 99%

In-vitro activity of sodium-hypochlorite gel on bacteria associated with periodontitis

et al. 2016

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2Objectives: The aim of the present study was to assess the antimicrobial activity of a sodium hypochlorite formulation incl. its components against bacteria associated with periodontal disease. Materials and Methods:Sodium hypochlorite formulation (NaOCl gel), its components sodium hypochlorite (NaOCl) and the activating vehicle were compared with 0.1% chlorhexidine digluconate (CHX) solution. The antimicrobial activity was proven by determination of minimal inhibitory concentrations (MIC), minimal bactericidal concentrations, and killing assays. Furthermore, the influence on formation as well as on a 4-days old 6-species biofilm was tested.Results: Except for one strain (Parvimonas micra ATCC 33270 in case of NaOCl gel) the MICs both of the CHX solution and NaOCl gel did not exceed 10% of the formulations' concentration. In general MICs of the NaOCl gel were equal as of the CHX solution against Gram-negatives but higher against Gram-positive bacteria. CHX but not NaOCl gel clearly inhibited biofilm formation, however the activity of NaOCl gel was more remarkable on a 4-d old biofilm. NaOCl killed bacteria in the biofilm and interfered with the matrix. Conclusions:The NaOCl gel acts antimicrobial in particular against Gram-negative species associated with periodontitis. Moreover, its component NaOCl hypochlorite is able to alter biofilm matrices.Clinical relevance: The NaOCl gel may represent a potential alternative for adjunctive topical antimicrobial treatment in periodontitis

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Section: Introductionmentioning

confidence: 99%

In-vitro activity of sodium-hypochlorite gel on bacteria associated with periodontitis

et al. 2016

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“…When associated to dentifrices, it has been successfully tested and used in order to enhance mechanical plaque control [14]. However, in this present trial, the association of 0.05% CHX with 0.3% triclosan did not result in additional benefits to gingival inflammation and plaque control in comparison with a dentifrice containing 0.3% triclosan.…”

Section: Discussionmentioning

confidence: 64%

“…CHX is the most effective anti-plaque and anti-gingivitis chemical agent in dentistry [14]. When associated to dentifrices, it has been successfully tested and used in order to enhance mechanical plaque control [14].…”

Section: Discussionmentioning

confidence: 99%

“…In dental practice, mouthwash is the most used form, though clinical studies has shown that CHX in dentifrices can also offer further benefits to oral health with less tooth discoloration [13]. Moreover, a meta-analysis performed in 2014 showed that CHX dentifrices provide a significant benefit on the treatment of gingivitis and plaque inhibition [14]. Besides that, when used for long periods, CHX has shown to produce local side effects such as tooth staining and taste disturbance [15,16].…”

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confidence: 99%

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Comparison of two commercial dentifrices in the reduction of gingivitis and plaque: A pilot study

Kerbauy

Maeda

Sendyk

et al. 2017

BDS

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Objectives: Chlorhexidine (CHX) and triclosan are the most used chemical agents in dentistry. However, the combination of these products has never been tested. We hypothesize that the addition of CHX to a triclosan dentifrice formulation may offer additional benefits in the reduction of plaque and gingivitis. Thus, the aim of this study was to compare a commercial dentifrice containing 0.05% chlorhexidine and 0.3% triclosan, with conventional toothpaste containing 0.3% triclosan, in the treatment of gingivitis and plaque reduction. Material and Methods: Thirty volunteers were randomly assigned to receive a dentifrice containing 0.05% CHX and 0.3% triclosan (CHX/triclosan group) or a dentifrice containing basically 0.3% triclosan (Triclosan group). Subjects received clinical evaluation such as gingival index (GI) and plaque index (PI) at baseline, 30 and 60 days. Results: After 60 days, both treatments led to a significant improvement in GI and PI. There was no significant difference between groups as regards change in GI and PI (p>0.05). Conclusion: The combination of 0.05% CHX with 0.3% triclosan did not offer further benefits to gingival inflammation and plaque control when compared with a dentifrice containing 0.3% triclosan.KeywordsChlorhexidine; CHX dentifrice; Triclosan; Plaque; Gingivitis.

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“…Bu nedenle son yıllarda klorheksidin glukonat, ksilitol gibi antimikrobiyal ajanların kullanımı ile mekanik plak kaldırma yöntemlerinin desteklendiği görülmektedir. [1][2][3][4] Ksilitol, çeşitli meyve ve sebzelerde düşük konsantrasyonda bulunan; doğal, 5 karbonlu bir şeker alkolüdür. Çok sayıda şekersiz üründe özellikle sakız ve pastillerde yaygın olarak bulunmaktadır.…”

Section: Introductionunclassified

Ksilitol emdirilmiş tek kullanımlık diş fırçasının plak kaldırma etkinliğinin 10-11 yaş grubu çocuklarda in vivo olarak değerlendirilmesi

Ulusu¹,

Inan²,

Kurt³

2017

Acta Odontologica Turcica

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The efficacy of chlorhexidine dentifrice or gel on plaque, clinical parameters of gingival inflammation and tooth discoloration: a systematic review

Cited by 59 publications

References 55 publications

In-vitro activity of sodium-hypochlorite gel on bacteria associated with periodontitis

In-vitro activity of sodium-hypochlorite gel on bacteria associated with periodontitis

Comparison of two commercial dentifrices in the reduction of gingivitis and plaque: A pilot study

Ksilitol emdirilmiş tek kullanımlık diş fırçasının plak kaldırma etkinliğinin 10-11 yaş grubu çocuklarda in vivo olarak değerlendirilmesi

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