The efficacy of disinfectants on abattoirs’ Candida albicans isolates in Niger Delta region

Olorode, Oluwayemisi A.; Okpokwasli, G Chijioke

doi:10.3410/f1000research.1-20.v1

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Total inhibition of C. albicans was achieved in 180 s with 5,000 ppm PCMX and in 60-90 s with 50,000 ppm PCMX [32]. Other reports indicated that 5,000 ppm totally inhibited C. albicans after 20 min [33]. The MLC (minimal lethal concentration) of PCMZ against Staphylococcus aureus was reported to be 1,250 ppm [34].…”

Section: Percent Inhibition Of C Albicans By Pcmx Cu and The Mixturementioning

confidence: 99%

Novel mixture of chloroxylenol and copper alters Candida albicans biofilm formation, biochemical characteristics, and morphological features

Gomaa

Almaghrabi

El-Shoura

et al. 2020

Journal of Taibah University for Science

View full text Add to dashboard Cite

The use of disinfectants has drastically increased in response to the growing public awareness of risks of microbial infection. However, this practice has a negative impact on the environment as it results in dumping large volumes of antimicrobial and microbicidal compounds in aquatic and terrestrial ecosystems. Chloroxylenol (PCMX) is a phenolic compound that poses public health and environmental risks art high concentrations. Here, a novel disinfectant was proposed to increase the lethality of PCMX by adding copper (Cu) to it. However, it was necessary to demonstrate that this mixture is fungicidal and not merely fungistatic, and that the addition of Cu does, in fact, increase PCMX lethality. We evaluated the fungicidal efficacy of PCMX/Cu on Candida albicans. PCMX/Cu synergy was explored on biofilm formation, biochemistry, and morphology of C. albicans. Inhibition increased with PCMX increased concentration. The combination of Cu and PCMX disrupted fungal ultrastructure, biofilm formation, and biochemical characteristic.

show abstract

Section: Percent Inhibition Of C Albicans By Pcmx Cu and The Mixturementioning

confidence: 99%

Novel mixture of chloroxylenol and copper alters Candida albicans biofilm formation, biochemical characteristics, and morphological features

Gomaa

Almaghrabi

El-Shoura

et al. 2020

Journal of Taibah University for Science

View full text Add to dashboard Cite

show abstract

“…HIV-positive) individuals [4,5]. C. albicans can grow in a variety of morphological forms, ranging from yeast form to pseudohyphae form to true tubular hyphae form, depending on the growth conditions in the host environment [6].…”

Section: Introductionmentioning

confidence: 99%

Identification of Infection- and Defense-Related Genes via a Dynamic Host-Pathogen Interaction Network Using a Candida Albicans-Zebrafish Infection Model

Kuo¹,

Chuang²,

Chao³

et al. 2013

J Innate Immun

View full text Add to dashboard Cite

Candida albicans infections and candidiasis are difficult to treat and create very serious therapeutic challenges. In this study, based on interactive time profile microarray data of C. albicans and zebrafish during infection, the infection-related protein-protein interaction (PPI) networks of the two species and the intercellular PPI network between host and pathogen were simultaneously constructed by a dynamic interaction model, modeled as an integrated network consisting of intercellular invasion and cellular defense processes during infection. The signal transduction pathways in regulating morphogenesis and hyphal growth of C. albicans were further investigated based on significant interactions found in the intercellular PPI network. Two cellular networks were also developed corresponding to the different infection stages (adhesion and invasion), and then compared with each other to identify proteins from which we can gain more insight into the pathogenic role of hyphal development in the C. albicans infection process. Important defense-related proteins in zebrafish were predicted using the same approach. The hyphal growth PPI network, zebrafish PPI network and host-pathogen intercellular PPI network were combined to form an integrated infectious PPI network that helps us understand the systematic mechanisms underlying the pathogenicity of C. albicans and the immune response of the host, and may help improve medical therapies and facilitate the development of new antifungal drugs.

show abstract

The efficacy of disinfectants on abattoirs’ Candida albicans isolates in Niger Delta region

Cited by 2 publications

References 0 publications

Novel mixture of chloroxylenol and copper alters Candida albicans biofilm formation, biochemical characteristics, and morphological features

Novel mixture of chloroxylenol and copper alters Candida albicans biofilm formation, biochemical characteristics, and morphological features

Identification of Infection- and Defense-Related Genes via a Dynamic Host-Pathogen Interaction Network Using a Candida Albicans-Zebrafish Infection Model

Contact Info

Product

Resources

About