2021
DOI: 10.1016/j.canrad.2020.08.049
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The efficacy of hypofractionated radiotherapy (HFRT) with concurrent and adjuvant temozolomide in newly diagnosed glioblastoma: A meta-analysis

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Cited by 8 publications
(8 citation statements)
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References 38 publications
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“…Fractionated RT regimens have demonstrated less radionecrosis compared to single-fraction radiosurgery [26], yet there is a limited information on radionecrosis from conventionally fractionated vs differential fractionated RT regimens. Similar clinical regimens to our preclinical schedule have reported no significant radiotoxicity-30 Gy/6 f over 2 weeks [24,25,[27][28][29]]-and we did not observe histological changes in irradiated brain tissue of 'tumor-free' animals at 80 days post-irradiation. Continuation of our fractionated RT regimen for 6 weeks is yet to be explored as the aggressive nature of syngeneic GB tumors prohibits a treatment course of this duration.…”
Section: Discussionsupporting
confidence: 77%
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“…Fractionated RT regimens have demonstrated less radionecrosis compared to single-fraction radiosurgery [26], yet there is a limited information on radionecrosis from conventionally fractionated vs differential fractionated RT regimens. Similar clinical regimens to our preclinical schedule have reported no significant radiotoxicity-30 Gy/6 f over 2 weeks [24,25,[27][28][29]]-and we did not observe histological changes in irradiated brain tissue of 'tumor-free' animals at 80 days post-irradiation. Continuation of our fractionated RT regimen for 6 weeks is yet to be explored as the aggressive nature of syngeneic GB tumors prohibits a treatment course of this duration.…”
Section: Discussionsupporting
confidence: 77%
“…72 h). A meta-analysis of hypofractionated RT with temozolomide in newly diagnosed GB patients found that hypofractionated RT increased overall and progression-free survival compared to conventional RT, with high-BED schedules improving 6-and 12-month progression-free survival over low-BED regimens [24]. Even moderate increases in fractional doses from 2 Gy to 2.2 or 2.4 Gy report good overall and progression-free survival with intensity-modulated radiotherapy regimens [25].One of the main concerns for utilising higher RT doses in fractionated regimens is increased radionecrosis and acute or long-term neurocognitive decline and neuroendocrine dysfunction.…”
Section: Discussionmentioning
confidence: 99%
“…Pearson's correlation test was used to calculate the correlation coefficient (r) and p-value, and generated regression lines fitted to each dot plot clinical researches are needed for verification. [24][25][26] As one of the most promising approaches in oncology field, immunotherapy have shown encouraging success for various types of cancer treatment. 3 However, the current prospects of immunotherapy for glioma are not optimistic.…”
Section: Discussionmentioning
confidence: 99%
“…Дискусія щодо місця гіпофракціонування в променевому лікуванні нейроонкологічних пацієнтів триває. Про це свідчать недавно опубліковані системні огляди та метааналізи [10][11][12][13][14][15].…”
Section: аналіз співвідношення ризику смерті та прогресування залежно...unclassified