The Efficacy of Kanamycin in the Treatment of Surgical Infections

Rutenburg, Alexander M.; Koota, Gordon M.; Schweinburg, Fritz B.

doi:10.1111/j.1749-6632.1958.tb54722.x

Cited by 7 publications

(1 citation statement)

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“…Two reports have identified P. fluorescens in skin wounds and abscesses following dog bites (190,191), and in one instance, the patient subsequently developed disseminated P. fluorescens bacteremia (191). P. fluorescens has been implicated as a cause of acute bacterial cystitis (192)(193)(194), both with (192) and without (193) the presence of an indwelling urinary catheter. In a study comparing the oral microbiomes of 20 solid organ transplant recipients and 19 nonimmunosuppressed control subjects, P. fluorescens was abundant in the saliva of nearly 50% of transplant subjects while being nearly absent from nontransplant controls (1).…”

Section: P Fluorescens As a Disease-causing Agentmentioning

confidence: 99%

Microbiology, Genomics, and Clinical Significance of the Pseudomonas fluorescens Species Complex, an Unappreciated Colonizer of Humans

et al. 2014

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SUMMARY Pseudomonas fluorescens is not generally considered a bacterial pathogen in humans; however, multiple culture-based and culture-independent studies have identified it at low levels in the indigenous microbiota of various body sites. With recent advances in comparative genomics, many isolates originally identified as the “species” P. fluorescens are now being reclassified as novel Pseudomonas species within the P. fluorescens “species complex.” Although most widely studied for its role in the soil and the rhizosphere, P. fluorescens possesses a number of functional traits that provide it with the capability to grow and thrive in mammalian hosts. While significantly less virulent than P. aeruginosa , P. fluorescens can cause bacteremia in humans, with most reported cases being attributable either to transfusion of contaminated blood products or to use of contaminated equipment associated with intravenous infusions. Although not suspected of being an etiologic agent of pulmonary disease, there are a number of reports identifying it in respiratory samples. There is also an intriguing association between P. fluorescens and human disease, in that approximately 50% of Crohn's disease patients develop serum antibodies to P. fluorescens . Altogether, these reports are beginning to highlight a far more common, intriguing, and potentially complex association between humans and P. fluorescens during health and disease.

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