The efficacy of LED microneedle patch on hair growth in mice

Kittigul, Leelawat; Meephansan, Jitlada; Sirithanabadeekul, Punyaphat; Hanvivattanakul, Sirashat; Deenonpoe, Raksawan; Yingmema, Werayut; Tantisantisom, Kittipong; Thongma, Sattra; Rayanasukha, Yossawat; Boonkoom, Thitikorn; Adulyaritthikul, Punyanuch; Khanchaitit, Paisan

doi:10.1007/s00403-022-02476-3

Cited by 8 publications

(4 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, the same type of MNP has also been developed for combined use with drug delivery and LED light therapy. In previous studies, it was found to be effective and free of adverse effects [18,24].…”

Section: Discussionmentioning

confidence: 97%

“…Microneedling can also stimulate collagen production by initiating the wound-healing cascade process [23]. In one study, the histopathology of skin treated with microneedles showed a slight thickening of the dermis, characterized by an abundance of collagen bundles, compared to areas not treated with microneedles across all experimental groups [24]. Microneedles stimulate the release of various growth factors from platelets and neutrophils, which in turn triggers the production of collagen and elastin in the papillary dermis.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Comparative Efficacy and Safety of 250 μm versus 350 μm Long Microneedle Patch on Under-Eye Skin

Arepagorn,

Meephansan,

Sirithanabadeekul

et al. 2024

Cosmetics

Self Cite

View full text Add to dashboard Cite

Background: Microneedle patch (MNP) technology is now applied for many purposes, including transdermal drug delivery and percutaneous collagen induction in the cosmetic and dermatology fields. Previous research showed that a MNP effectively improved skin appearance, while treatments using larger or deeper microneedles were not easily tolerated by human subjects. Few studies have compared MNP designs in humans. Study Objective: To compare novel MNP designs with high length and low density versus low length and high density for rejuvenating skin wrinkles under the eyes. Methods: This non-randomized split-face clinical trial was conducted as a double-blind study with 36 Thai female participants. Each participant was treated with two different MNP designs, one on each side of the face. The microneedle lengths were 250 μm with a density of 945 needles/cm2 on the left side of the face under the eye and 350 μm with a density of 482 needles/cm2 on the right side of the face under the eye. The treatments were applied for 12 weeks, with the assessment outcomes evaluated at the baseline and 2, 4, 6, 8, 10, and 12 weeks. Results: The application of these two novel MNP designs successfully rejuvenated under-eye wrinkles with low pain level scores. Increasing the length of the needle or having a 350 μm long MN can better reduce under-eye wrinkles without statistical significance. During the study period, there was an improvement in skin surface roughness in both groups accompanied by a consistent reduction in under-eye skin wrinkles, without statistically significant differences observed between the groups when using the Antera 3D system. However, the 350 μm long MN also slightly increased the pain compared to the shorter needles (250 μm long MN) with a higher density of needles. There were no side effects associated with the two designs. Conclusions: The two novel MNPs gave favorable results as a safe non-invasive treatment for the rejuvenation of skin wrinkles under the eyes. Increasing the number of needles and increasing the length of the needles were both effective in safely reducing under-eye wrinkles without any adverse effects. Additionally, participants could self-apply them at home and were highly satisfied. However, increasing the length of the needles may result in slightly more pain compared to increasing the number of needles.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

The Comparative Efficacy and Safety of 250 μm versus 350 μm Long Microneedle Patch on Under-Eye Skin

Arepagorn,

Meephansan,

Sirithanabadeekul

et al. 2024

Cosmetics

Self Cite

View full text Add to dashboard Cite

show abstract

“…CL and EXO synergistically promote hair regrowth and regulate the circulation of hair follicles 295 . Animal studies have shown that drug‐free microneedle patches significantly promote hair regrowth within 7 days, compared with the typically administered minoxidil at lower doses 296,297 . Microneedles deliver stem cell secretomes directly to the site of injury, demonstrating the relative therapeutic benefits of live cells while avoiding potential limitations 298 .…”

Section: Other Systems Loaded With Stem Cells and Exosomesmentioning

confidence: 99%

“… 295 Animal studies have shown that drug‐free microneedle patches significantly promote hair regrowth within 7 days, compared with the typically administered minoxidil at lower doses. 296 , 297 Microneedles deliver stem cell secretomes directly to the site of injury, demonstrating the relative therapeutic benefits of live cells while avoiding potential limitations. 298 To improve the efficacy, a variety of biomaterials have been developed for the continuous and controlled delivery of stem cell secretomes.…”

Section: Other Systems Loaded With Stem Cells and Exosomesmentioning

confidence: 99%

Application of stem cells in regeneration medicine

Jin

et al. 2023

MedComm

View full text Add to dashboard Cite

Regeneration is a complex process affected by many elements independent or combined, including inflammation, proliferation, and tissue remodeling. Stem cells is a class of primitive cells with the potentiality of differentiation, regenerate with self‐replication, multidirectional differentiation, and immunomodulatory functions. Stem cells and their cytokines not only inextricably linked to the regeneration of ectodermal and skin tissues, but also can be used for the treatment of a variety of chronic wounds. Stem cells can produce exosomes in a paracrine manner. Stem cell exosomes play an important role in tissue regeneration, repair, and accelerated wound healing, the biological properties of which are similar with stem cells, while stem cell exosomes are safer and more effective. Skin and bone tissues are critical organs in the body, which are essential for sustaining life activities. The weak repairing ability leads a pronounced impact on the quality of life of patients, which could be alleviated by stem cell exosomes treatment. However, there are obstacles that stem cells and stem cells exosomes trough skin for improved bioavailability. This paper summarizes the applications and mechanisms of stem cells and stem cells exosomes for skin and bone healing. We also propose new ways of utilizing stem cells and their exosomes through different nanoformulations, liposomes and nanoliposomes, polymer micelles, microspheres, hydrogels, and scaffold microneedles, to improve their use in tissue healing and regeneration.

show abstract