2020
DOI: 10.21203/rs.3.rs-50122/v2
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The efficacy of mesenchymal stromal cell-derived therapies for acute respiratory distress syndrome—a meta-analysis of preclinical trials.

Abstract: Background: The investigation of mesenchymal stromal cell (MSC)-conditioned medium or extracellular vesicles (exosomes or microvesicles) as a remedy for acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) has become a fast-growing field in recent years. Our purpose was to conduct a meta-analysis to investigate the efficacy of MSC-derived therapies (MDTs) for ALI/ARDS in animal models.Methods: A meta-analysis of MDTs for ALI/ARDS in animal trials was performed. PubMed and EMBASE were searched … Show more

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“…7 However, mesenchymal stem cells which was investigated extensively in recent years might be an eligible candidate. [8][9][10][11] In the entire course of his illness, the serum IL-6 (62 pg/mL), ferritin (1.21 g/L), and LDH (780 U/L) only had a slight elevation in the early period, there is no typical cytokine storm as that was seen in non-COVID-19 ARDS. The COVID-19 associated thrombosis has been noticed by many clinicians, 12,13 heparin was regularly used to prevent thrombosis even after the patient was weaned from ECMO.…”
Section: Discussionmentioning
confidence: 90%
“…7 However, mesenchymal stem cells which was investigated extensively in recent years might be an eligible candidate. [8][9][10][11] In the entire course of his illness, the serum IL-6 (62 pg/mL), ferritin (1.21 g/L), and LDH (780 U/L) only had a slight elevation in the early period, there is no typical cytokine storm as that was seen in non-COVID-19 ARDS. The COVID-19 associated thrombosis has been noticed by many clinicians, 12,13 heparin was regularly used to prevent thrombosis even after the patient was weaned from ECMO.…”
Section: Discussionmentioning
confidence: 90%