2017
DOI: 10.7589/2016-05-107
|View full text |Cite
|
Sign up to set email alerts
|

THE EFFICACY OF NALBUPHINE, MEDETOMIDINE, AND AZAPERONE IN IMMOBILIZING AMERICAN BISON (BISON BISON)

Abstract: We evaluated a combination of nalbuphine, medetomidine, and azaperone (NalMed-A) in 12 American bison ( Bison bison ) during 13 sedation handling events. The mean (SE) dosage was 0.4 (0.02) mg/kg nalbuphine, 0.08 (0.003) mg/kg medetomidine, and 0.08 (0.003) mg/kg azaperone contained in an average delivery volume of 0.8 mL/100 kg. Two animals required a supplemental dose for safe handling (additive dose used in calculating means) and a third animal was not adequately sedated despite a supplemental dose. Bison i… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2

Citation Types

2
20
0

Year Published

2018
2018
2023
2023

Publication Types

Select...
6
1

Relationship

2
5

Authors

Journals

citations
Cited by 16 publications
(22 citation statements)
references
References 16 publications
2
20
0
Order By: Relevance
“…It has several related nerve-stabilizing effects on farm livestock. Intramuscular injection of this drug is used to relieve tension in animals and reduce their activity. It can make animals indifferent to their environment and keep them in a quiet state for a long term, which is conducive to avoiding fighting when animals live together and in mixed groups. Therefore, it is often used for animals such as pigs during long-distance transportation. With the widespread application of this drug in veterinary medicine, the problem of its residue in animal tissues and the direct harm to human health caused by its toxic side effects have attracted extensive attention.…”
Section: Introductionmentioning
confidence: 99%
“…It has several related nerve-stabilizing effects on farm livestock. Intramuscular injection of this drug is used to relieve tension in animals and reduce their activity. It can make animals indifferent to their environment and keep them in a quiet state for a long term, which is conducive to avoiding fighting when animals live together and in mixed groups. Therefore, it is often used for animals such as pigs during long-distance transportation. With the widespread application of this drug in veterinary medicine, the problem of its residue in animal tissues and the direct harm to human health caused by its toxic side effects have attracted extensive attention.…”
Section: Introductionmentioning
confidence: 99%
“…Ideally, these alternatives would provide improved deep sedation, muscle relaxation, adequate analgesia, capability for reversal, short duration of quiet recovery and post-recovery behaviors, and discourage induction or exacerbation of adverse physiological responses (e.g., hyperthermia, capture myopathy). Two drug combinations used successfully in other wildlife species include butorphanolazaperone-medetomidine (BAM™) and nalbuphineazaperone-medetomidine (NalMed-A) which have proved effective for immobilization of black bear (Ursus americanus), elk (Cervus canadensis), bison (Bison bison), and ibex (Capra nubiana) (Mich et al 2008;Wolfe et al 2008;Miller et al 2009;Wolfe et al 2014aWolfe et al , 2014bWolfe et al , 2017Wolfe et al, 2014a, b;Lapid and Shilo-Benjamini 2015). Medetomidine-midazolam-butorphanol (MMB) is a drug combination used successfully for sedation of domestic and pet pigs in veterinary medicine (Wolff 2009).…”
Section: Introductionmentioning
confidence: 99%
“…Although inbreeding effects and malformations may characterize reintroduced populations (Lacy 1997), this risk was presumably minimized by translocating 1,553 elk from several source states (Youngmann et al 2020). A severe hypoxic event might have occurred during chemical immobilization of the dam during early pregnancy, but because the cow received supplemental oxygen during immobilization (Wolfe et al 2017), it was considered unlikely. Elk are susceptible to bovine viral diarrhea virus (BVDV) and bluetongue virus (Corn et al 2010), known teratogens in cattle (Agerholm et al 2015).…”
mentioning
confidence: 99%