The efficacy of nasal airway stent (Nastent) on obstructive sleep apnoea and prediction of treatment outcomes

Okuno, Kentaro; Minagi, Hitomi Ono; Ikai, Kazuki; Ai, E Matsumura; Takai, Etsuko; Fukatsu, Hikari; Uchida, Yurika; Sakai, Takayoshi

doi:10.1111/joor.12725

Cited by 8 publications

(15 citation statements)

References 26 publications

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“…Previous studies have shown that the NAS can reduce the AHI scores of patients without OSAS surgery [19, 26]. However, these studies had a small number of participants and long-term effects were not assessed.…”

Section: Discussionmentioning

confidence: 99%

“…The Mallampati classification is an established method for assessing the pharynx status [31]. Interestingly, a previous study has used it to evaluate the NAS effect on the pharynx status [26]; therefore, we decided to use the Mallampati classification in the present study. We demonstrated that patients with Mallampati class II tended to show more improvements after using the NAS compared to the other Mallampati classification groups.…”

Section: Discussionmentioning

confidence: 99%

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The Effectiveness of Nasal Airway Stent Therapy for the Treatment of Mild-to-Moderate Obstructive Sleep Apnea Syndrome

et al. 2020

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Background: Patients with obstructive sleep apnea syndrome (OSAS) experience excessive daytime sleepiness and insomnia and they are at risk of developing cardiovascular disease and stroke. Continuous positive airway pressure therapy could improve symptoms and decrease these risks; however, adherence is problematic. Although the oral appliance is another therapeutic option, patient satisfaction is limited and the effect of the nasal airway stent – a new device – remains unclear. Objectives: The aim of this study was to evaluate the effect of NAS therapy in patients with mild-to-moderate OSAS in a prospective, single-arm, interventional pilot study. Method: Patients with mild/moderate sleep apnea (n = 71; Apnea-Hypopnea Index [AHI], 5–20 events/h on polysomnography) were recruited. Sleep-associated events were measured using a portable device (WatchPAT200) pre- and immediately post-treatment and at 1 month follow-up. AHI (including supine and non-supine AHI), Oxygen Desaturation Index (ODI), Respiratory Disturbance Index (RDI), percutaneous oxygen saturation, heart rate, and snore volume were evaluated. Symptoms were assessed using the Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, and Hospital Anxiety and Depression Scale. Results: NAS use significantly improved AHI, supine AHI, RD, ODI, and snore volume compared to pre-intervention (r = 0.44, 0.48, 0.3, 0.42, and 0.34; p < 0.001, p < 0.001, p = 0.011, p < 0.001, and p = 0.048, respectively). Additionally, 25 and 10% of patients showed complete and partial response for AHI, respectively; these improvements remained significant 1 month later. Pittsburgh Sleep Quality Index scores improved from 6.0 to 5.3 (r = 0.46, p = 0.022). Conclusions: NAS therapy reduced severity and snoring in patients with mild-to-moderate OSAS. Approximately 30% of patients did not tolerate NAS due to side effects.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Effectiveness of Nasal Airway Stent Therapy for the Treatment of Mild-to-Moderate Obstructive Sleep Apnea Syndrome

et al. 2020

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“…The tube is inserted transnasally with the intention of stenting the palatal velum (Figure 1(b)–(d)) to reduce snoring, hypopneas, or apneas. 4…”

Section: Methodsmentioning

confidence: 99%

“…Okuno et al. 4 demonstrated a significant reduction in snoring and the respiratory disturbance index (RDI) using a nasopharyngeal stent (Naśtent; Corinium Medical Equipment Ltd., Cirencester, UK). They also demonstrated an association between responders and a narrow velopharynx in cephalography.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of a nasopharyngeal stent in patients with obstructive sleep-related breathing disorders

2022

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Objective This study was performed to evaluate the therapeutic effect and diagnostic value of a novel nasopharyngeal stent (Naśtent; Corinium Medical Equipment Ltd., Cirencester, UK). The Naśtent is designed to stent palatal collapse in patients with sleep-related breathing disorders. Methods The study was conducted from 2018 to 2019. Patients who did not qualify for continuous positive airway pressure therapy underwent split-night examination with an inserted Naśtent for the first half of the night. The next morning, drug-induced sleep endoscopy (DISE) was performed. Results Of the 122 enrolled patients, 21 were excluded because of Naśtent intolerance (n = 14) or technically invalid examinations (n = 7). Among the remaining 101 patients, in correlation with DISE, the apnea–hypopnea index was significantly reduced in patients with palatal obstructions, mainly in those with anteroposterior collapse patterns. The Naśtent did not influence retrolingual or multilevel obstructions. Using a 40% reduction of the apnea–hypopnea index by the Naśtent as a cut-off value, 85.7% of soft palate obstructions were detected compared with DISE. Conclusions The Naśtent is a viable tool to reduce palatal obstructions, although it is not readily tolerated. It may also be helpful for diagnosis of sleep-related breathing disorders when DISE is unavailable.

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A Novel Method to Classify the Responses of Genioglossus to Negative Pressure in OSA Patients

Zhou,

Yin,

et al. 2023

Otolaryngol.--head neck surg.

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ObjectiveThis study aims to develop a novel method to classify different genioglossus (GG) responses to upper airway (UA) negative pressure in obstructive sleep apnea (OSA) patients.Study DesignA single‐center, prospective, cohort study.SettingSleep Medical Center.MethodsPatients with OSA underwent drug‐induced sleep endoscopy with synchronous genioglossus electromyography (ggEMG) and UA pressure monitoring. In spontaneous obstructive apnea events, the value of epiglottis negative pressure at the end of inspiration (Pepi) and corresponding peak phasic ggEMG were recorded as pairing data for linear regression analysis to classify GG response modes: peak phasic ggEMG‐Pepi linear mode (P < .05) were classified as group 1; others (P ≥ .05) were classified as group 2. Using nasopharyngeal tube (NPT) to reopen the palatopharyngeal cavity for comparing the improvement between the OSA patients with different GG response modes.ResultsSixty subjects were analyzed for GG response modes: 22 patients were in group 1 (r2 = 0.233‐0.867), and 38 patients were in group 2. The proportion of partial (63.16% vs 59.09%) or complete (36.84% vs 22.73%) collapse rate of the tongue base in group 2 was significantly higher (χ2 = 7.823, P = .020). The improvement of the apnea‐hypopnea index after NPT placement in group 2 was significantly lower than in group 1 (59.09% vs 31.58%, χ2 = 4.339, P = .037).ConclusionThis novel method is advantageous for distinguishing OSA patients with different GG response abilities to UA negative pressure, whose GG responses conforming to peak phasic ggEMG‐Pepi linear mode might be more suitable for palatopharyngeal surgery.

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The efficacy of nasal airway stent (Nastent) on obstructive sleep apnoea and prediction of treatment outcomes

Cited by 8 publications

References 26 publications

The Effectiveness of Nasal Airway Stent Therapy for the Treatment of Mild-to-Moderate Obstructive Sleep Apnea Syndrome

The Effectiveness of Nasal Airway Stent Therapy for the Treatment of Mild-to-Moderate Obstructive Sleep Apnea Syndrome

Evaluation of a nasopharyngeal stent in patients with obstructive sleep-related breathing disorders

A Novel Method to Classify the Responses of Genioglossus to Negative Pressure in OSA Patients

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