The efficacy of psychopharmacotherapy of late onset depression: the optimization of treatment duration

Ivanets, N. N.; Kinkulkina, M. A.; Avdeeva, T. I.; Tikhonova, Yu. G.; Lukyanova, Anna

doi:10.17116/jnevro20161164116-27

Cited by 2 publications

(1 citation statement)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Причинные факторы включают также ориентацию на материальное потребление в ущерб духовным интересам, одиночество и социальную изоляцию, в которой особенно часто в наше время оказываются пожилые люди. Наконец, определенную роль играет увеличение продолжительности жизни населения почти во всех странах мира, ибо пожилой возраст, в котором учащаются соматические болезни (сердечно-сосудистые, онкологические), также является фактором риска возникновения депрессий [4][5][6][7].…”

Section: психиатрия оригинальные исследованияunclassified

Modern approaches to the diagnosis and treatment of mixed anxiety-depressive disorders in primary health care

Распопова

Dzhamantayeva

Nurkatov³

et al. 2021

Medicine

View full text Add to dashboard Cite

The relevance of this work is due to the wide prevalence of mixed anxiety-depressive disorders among general medical practice patients. At the present stage of development of the psychiatric service in the Republic of Kazakhstan, a new concept has been developed that assumes the transfer of a number of borderline mixed anxiety-depressive disorders to the competence of PHC doctors with the need for their treatment with modern antidepressants. The purpose of this work. Development and implementation in general clinical practice of modern methods of diagnosis and treatment of mixed anxiety-depressive disorders. Material and methods. 30 patients with mixed anxiety-depressive disorders of the borderline level, who were treated on an outpatient basis (Nursultan) was examined. The study was conducted using international psychometric scales: Hospital Anxiety and Depression Score (HADS), Hamilton Anxiety and Depression Rating Scale (HDRS, HAM-A). Results and discussion. As a result of the study, it was found that among patients with mixed anxiety-depressive disorders who were treated on an outpatient basis, young people of working age from 21 to 50 years (83.3%) prevailed, in whom psychogenic anxiety-depressive disorders accounted for 60%. In the course of clinical observations, objective data were obtained indicating that when treating depressive states of mild and moderate severity with Mianserin drug on an outpatient basis, by the end of the second week of treatment, there is a fairly pronounced positive dynamics in the reduction of symptoms of depression. By the end of the second month of taking this drug (8 weeks), most patients had no symptoms of depression. Conclusions. Practical clinical observations have shown that the modern Mianserin antidepressant, possessing a wide range of clinical effects combining thymoanaleptic action proper with anti-anxiety, sedative and hypnotic effects is well tolerated by patients and can be recommended for widespread use in the treatment of mixed anxiety-depressive disorders in general medical practice. Keywords: depression, anxiety, primary health care, general medical practice, antidepressants.

show abstract

Section: психиатрия оригинальные исследованияunclassified

Modern approaches to the diagnosis and treatment of mixed anxiety-depressive disorders in primary health care

Распопова

Dzhamantayeva

Nurkatov³

et al. 2021

Medicine

View full text Add to dashboard Cite

show abstract

Late-Life Depression Treatment: the State of the Art

Сафарова¹

2020

Psychiatry

View full text Add to dashboard Cite

Purpose: to present an overview of domestic and foreign current research covering the treatment of late-life depression.Materials and method: the keywords “depressive disorder”, “late age”, “psychopharmacotherapy” were used to search for scientific articles in the databases MedLine, PubMed for the period 2000–2020.Discussion and conclusions: the variability of multiple aging factors in depressive patients of late age leads to significant heterogeneity of geriatric depressions and difficulties in selection of therapy. In the current literature on the treatment of late-life depression, there are quite heterogeneous recommendations on the choice of different drugs, recommended dosages, duration of therapy and time to replace drugs if they are ineffective. The global trend of transition to personalized therapy of mental diseases requires identification of predictors of therapeutic response in patients. Significant data has already been accumulated on potential predictors of therapeutic response to antidepressants in young and middle-aged patients using clinical, neurobiological, neurocognitive and genetic parameters. The search for predictors of therapeutic response is especially important in late life, since the selection of adequate antidepressant therapy is associated not only with the effectiveness, but also with the safety of treatment of elderly patients. To date our knowledge of the problem of predicting the therapeutic response in this group of patients remains very limited and requires further study

show abstract

The efficacy of psychopharmacotherapy of late onset depression: the optimization of treatment duration

Cited by 2 publications

References 54 publications

Modern approaches to the diagnosis and treatment of mixed anxiety-depressive disorders in primary health care

Modern approaches to the diagnosis and treatment of mixed anxiety-depressive disorders in primary health care

Late-Life Depression Treatment: the State of the Art

Contact Info

Product

Resources

About