The Efficacy of Stinging Nettle (Urtica Dioica) in Patients with Benign Prostatic Hyperplasia: A Randomized Double-Blind Study in 100 Patients

Ghorbanibirgani, Alireza; Khalili, Ali; Zamani, L

doi:10.5812/ircmj.2386

Cited by 19 publications

(3 citation statements)

References 2 publications

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“…Nettle also inhibits proteolytic enzyme, which is involved in genitourinary tract infection/inflammation, but it is a very weak inhibitor of 5-α-reductase. Some studies have documented that nettle only relieves the symptoms of an enlarged prostate without eliminating the enlargement itself (Ghorbanibirgani et al, 2013). On the contrary, Safarinejad (2005) documented a modest decrease in prostate size measured by transrectal ultrasonography in BPH patients treated with nettle for 6 months.…”

mentioning

confidence: 99%

Phytotherapy of Benign Prostatic Hyperplasia. A Minireview

Pagano

Laudato

Griffo

et al. 2013

Phytotherapy Research

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Benign prostate hyperplasia (BPH) is a common condition affecting older men, with an incidence that is age-dependent. Histological BPH, which typically develops after the age of 40 years, ranges in prevalence from >50% at 60 years to as high as 90% by 85 years of age. Typical symptoms include increased frequency of urination, nocturia, urgency, hesitancy, and weak urine stream. Conventional medicines used for the treatment of BPH include alpha blockers and 5-alpha reductase inhibitors. This articles review the mode of action, the efficacy, and the safety, including herb-drug interactions of the most common botanicals (Serenoa repens, Pygeum africanum, Urtica dioica, and Cucurbita pepo) and nutraceuticals (isoflavones, lycopene, selenium, and β-Sitosterol) in controlling the lower urinary tract symptoms associated to BPH.

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mentioning

confidence: 99%

Phytotherapy of Benign Prostatic Hyperplasia. A Minireview

Pagano

Laudato

Griffo

et al. 2013

Phytotherapy Research

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“…[5] Antiproliferative, anti-inflammatory, antioxidant, and antiviral properties of UD (also known as stinging nettle) have been demonstrated in many studies. [6,7] Protective effect against renal I/R injury and hepatic damage related to biliary tract obstruction have been also reported. [8,9] As far as we know, the impact of UD on testicular I/R injury has been investigated in only a very few studies.…”

Section: Introductionmentioning

confidence: 93%

Protective Role of Urtica Dioica on Testicular Torsion/Detorsion-Induced Ischemia-Reperfusion Injury in Rats

AKDERE¹

2017

South Clin Ist Euras

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“…Benign prostatic hyperplasia (BPH) is a chronic disease associated with aging in men but its exact cause remains unknown [1] . BPH often causes bladder outlet obstruction, lower urinary tract symptoms, and, in severe cases, renal failure and bladder decompensation [2] .…”

Section: Introductionmentioning

confidence: 99%

Alleviatory effect of isoquercetin on benign prostatic hyperplasia via IGF-1/PI3K/Akt/mTOR pathway

Choi,

Fan,

Wedamulla

et al. 2024

Food Science and Human Wellness

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We evaluated the effect of isoquercetin (quercetin-O-3-glucoside-quercetin, IQ) as a functional component of Abeliophyllum disistichum Nakai ethanol extract (ADLE) on prostate cell proliferation and apoptosis and its effects on the IGF-1/PI3K/Akt/mTOR pathway in benign prostatic hyperplasia (BPH). Metabolites in ADLE were analyzed using UHPLC-qTOF-MS and HPLC. IQ was orally administered (1 or 10 mg/kg) to a testosterone propionate-induced BPH rat model, and its effects on the prostate weight were evaluated. The effect of IQ on androgen receptor (AR) signaling was analyzed in LNCaP cells. Whether IGF-1 and IQ affect the IGF-1/PI3K/Akt/mTOR pathway in BPH-1 cells was also examined. The metabolites in ADLE were identifi ed and quantifi ed, which confi rmed that ADLE contained abundant IQ (20.88 mg/g). IQ signifi cantly reduced the prostate size in a concentration-dependent manner in a BPH rat model, and signifi cantly decreased the expression of AR signaling factors in the rat prostate tissue and LNCaP cells in a concentration-dependent manner. IQ also inhibited the PI3K/AKT/mTOR pathway activated by IGF-1 treatment in BPH-1 cells. In BPH-1 cells, IQ led to G0/G1 arrest and suppressed the expression of proliferation factors while inducing apoptosis. Thus, IQ shows potential for use as a pharmaceutical and nutraceutical for BPH.

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The Efficacy of Stinging Nettle (Urtica Dioica) in Patients with Benign Prostatic Hyperplasia: A Randomized Double-Blind Study in 100 Patients

Cited by 19 publications

References 2 publications

Phytotherapy of Benign Prostatic Hyperplasia. A Minireview

Phytotherapy of Benign Prostatic Hyperplasia. A Minireview

Protective Role of Urtica Dioica on Testicular Torsion/Detorsion-Induced Ischemia-Reperfusion Injury in Rats

Alleviatory effect of isoquercetin on benign prostatic hyperplasia via IGF-1/PI3K/Akt/mTOR pathway

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