The efficacy of tes-therapy for treatment of anxiety-like behavior and motor disorders in rats with an experimental model of parkinsonism

Каде, А. Х.; Кравченко, С. В.; Trofimenko, A. I.; Chaplygina, K Yu; Ананьева, Е. И.; Поляков, П. П.; Липатова, А С

doi:10.17116/jnevro201911909191

Cited by 4 publications

(1 citation statement)

References 21 publications

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“…However, this study did not observe changes in depression-like behaviors or recognition memory. Utilizing a rotenoneinduced rat model of PD, Kade, et al [73] showed that transcranial electrostimulation-a variation on tACS developed by this group that is similar to cranial electrostimulation therapy-was able to reduce neurodegeneration in the SN and anxiety-like behavior when applied over the frontal cortex. It is important to note that this study did not include a sham electrical stimulation group, unlike the studies discussed thus far.…”

Section: Animal Modelsmentioning

confidence: 99%

Noninvasive Neuromodulation in Parkinson’s Disease: Insights from Animal Models

Muksuris,

Scarisbrick,

Mahoney

et al. 2023

JCM

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The mainstay treatments for Parkinson’s Disease (PD) have been limited to pharmacotherapy and deep brain stimulation. While these interventions are helpful, a new wave of research is investigating noninvasive neuromodulation methods as potential treatments. Some promising avenues have included transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), electroconvulsive therapy (ECT), and focused ultrasound (FUS). While these methods are being tested in PD patients, investigations in animal models of PD have sought to elucidate their therapeutic mechanisms. In this rapid review, we assess the available animal literature on these noninvasive techniques and discuss the possible mechanisms mediating their therapeutic effects based on these findings.

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Section: Animal Modelsmentioning

confidence: 99%

Noninvasive Neuromodulation in Parkinson’s Disease: Insights from Animal Models

Muksuris,

Scarisbrick,

Mahoney

et al. 2023

JCM

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Antiatherogenic Potential of Transcranial Electrical Stimulation in a High-Fructose/High-Fat Diet: Experimental Randomized Trial

Chabanets

Каде

Trofimenko

et al. 2023

Kuban. nauсh. med. vestnik

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Background. Transcranial electrical stimulation is a promising method for correction of malnutrition-induced hyperlipidemia, in the absence of indications for drug hypolipidemic therapy in young and middle-aged patients with low and moderate cardiovascular risk. Objectives — to study the effect of transcranial electrical stimulation on lipid metabolism in a high-fructose/high-fat (HFHF) diet in rats.Methods. An experimental randomized trial was performed to study the effect of transcranial electrical stimulation on lipid metabolism in a high-calorie diet enriched with fructose and saturated animal fat in rats. The experiments involved 180 outbred male rats and were carried out on the basis of the vivarium of Kuban State Medical University. The animals were divided into three groups: group 1 (control group, n = 60) — followed a standard diet; group 2 (comparison group, n = 60) — followed a HFHF diet; group 3 (experimental group, n = 60) — underwent transcranial electrical stimulation against the background of a HFHF diet. According to the target reference point of the study, the groups were divided into three equal subgroups of 20 rats each: subgroup A — day 30, subgroup B — day 60, and subgroup C — day 90 (biomaterial sampling and euthanasia were carried out on those days). In the obtained blood samples, the following lipid metabolism parameters were evaluated: total cholesterol, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and atherogenic index. Statistical analysis was performed using Microsoft Office Excel 2021 (Microsoft, USA), GraphPadPrism 9 (GraphPad Software, USA) and Statistica 13.3 (StatSoft, USA).Results. On the 30th day of the study, it was noted that in group 3, the concentration of low-density lipoprotein cholesterol was 14.9% lower and the atherogenic index was 30.8% lower (p < 0.05) than in group 2, while total cholesterol concentration, triglycerides, and high-density lipoprotein cholesterol had no statistically significant differences (p > 0.05). On the 60th day of the study, in group 3, when compared to group 2, the concentration of total cholesterol was 18.7% lower, low-density lipoprotein cholesterol was 42.9% lower, high-density lipoprotein cholesterol was 16.7% higher, and the atherogenic index was 56.3% lower (p < 0.05), while triglycerides had no statistically significant differences (p > 0.05). On the 90th day of the study, in group 3, when compared to group 2, the concentration of total cholesterol was 29.2% lower, the concentration of triglycerides was 36.0% lower, low-density lipoprotein cholesterol was 42.8% lower, and the atherogenic index was 57.0% lower (p < 0.05), while the concentration of high-density lipoprotein cholesterol had no statistically significant differences (p > 0.05).Conclusion. High-fructose/high-fat diet leads to a progressive increase in the serum concentration of low-density lipoprotein cholesterol, total cholesterol, triglycerides, as well as to a moderate decrease in high-density lipoprotein cholesterol and a growth in the atherogenic index. Transcranial electrical stimulation has a moderate lipid-lowering effect, manifested in the form of a decrease in the serum concentration of low-density lipoprotein cholesterol, total cholesterol and atherogenic index, while the effect on the concentration of triglycerides and high-density lipoprotein cholesterol is insignificant.

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Cognitive neural prosthetics – the way from experiment to clinical application

Kravchenko

Каде

Trofimenko

et al. 2021

Innovacionnaâ medicina Kubani

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Accepted: September 3, 2021. Objective of this review is to highlight some aspects of the development and use of cognitive neuroprostheses, such as the technological background for their developing and key modern projects in this field. The literature sources were analyzed and the place of neuroprostheses among other artificial organs and tissues, which are under development or already used in clinical practice, was defined. The main principles of their implementation, structural elements and operating conditions were described. Also, this review presents some examples of diseases which can be corrected by cognitive neuroprostheses. The mechanisms of compensation for the functions of the damaged brain structures when using neuroprostheses are described on the basis of the principles of their interaction with biological neural networks. Descriptions of advanced developments that are currently relevant are given. Moreover, information is provided on the protocols and results of tests on animals and humans of the artificial hippocampus, as well as the results of testing a prosthesis that allows restoring the functions of the prefrontal cortex in animals. The examples considered in the review allow us to conclude that cognitive neuroprostheses are not just a hypothetic concept. They are implemented as specialized experimental solutions for practical clinical issues. Currently, the greatest success has been achieved in restoring the hippocampus functions.

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The efficacy of tes-therapy for treatment of anxiety-like behavior and motor disorders in rats with an experimental model of parkinsonism

Cited by 4 publications

References 21 publications

Noninvasive Neuromodulation in Parkinson’s Disease: Insights from Animal Models

Noninvasive Neuromodulation in Parkinson’s Disease: Insights from Animal Models

Antiatherogenic Potential of Transcranial Electrical Stimulation in a High-Fructose/High-Fat Diet: Experimental Randomized Trial

Cognitive neural prosthetics – the way from experiment to clinical application

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