The Efficacy of Transcorneal Electrical Stimulation for the Treatment of Primary Open-angle Glaucoma: A Pilot Study

Ota, Yuka; Ozeki, Naoki; Yuki, Kenya; Shiba, Daisuke; Kimura, Ikuo; Tsunoda, Kazushige; Shinoda, Kei; Ohde, Hisao; Ohta, Michio

doi:10.2302/kjm.2017-0015-oa

Cited by 23 publications

(17 citation statements)

References 21 publications

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“…Pre-chiasmatic rtACS Age-related macular degeneration Gall et al,2010;Fedorov et al, 2011;Gall et al, 2011;Schmidt et al, 2013;Bola et al, 2014;Gall et al, 2016;Shinoda et al, 2008;Anastassiou et al, 2013;Chaikin et al, 2015;Gil-Carrasco et al, 2018;Fujikado et al, 2006;Inomata et al, 2007;Oono et al, 2011;Schatz et al, 2011;Naycheva et al, 2013;Ozeki et al, 2013;Robles-Camarillo et al, 2013;Schatz et al, 2017;Bittner et al, 2018;Bittner et al, 2018;Ota et al, Campana et al, 2014;Camilleri et al, 2016;Moret et al, 2018;Halko et al, 2011;Plow et al, 2011;Plow et al, 2012a;Plow et al, 2012b;Cowey et al, 2013;Olma et al, 2013;Ding et al, 2016;Kim et al, 2016;Alber et al, 2017;Matteo et al, 2017 tDCS Post-stroke visual perception degradation Amblyopia Myopia Notes: rtACS: repetitive transorbital alternating current stimulation, tpES: transpalpebral electrical stimulation, tcES: transcorneal electrical stimulation, hf-tRNS: high-frequency random noise stimulation, tDCS: transcranial direct current stimulation. studies used this technique to treat retinitis pigmentosa.…”

Section: Site Of Stimulation Kind Of Clinical Conditions First Authormentioning

confidence: 99%

Non-invasive current stimulation in vision recovery: a review of the literature

Perin

Viganò

Piscitelli

et al. 2019

Restorative Neurology and Neuroscience

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Background: Around 253 million people worldwide suffer from irreversible visual damage. Numerous studies have been carried out in order to unveil the effects of electrical stimulation (ES) as a useful tool for rehabilitation for different visual conditions and pathologies. Objective: This systematic review aimed to 1) examine the current evidence of ES efficacy for the treatment of visual pathologies and 2) define the corresponding degree of the recommendation of different ES techniques. Methods: A systematic review was conducted in MEDLINE and Cochrane Library database to collect documents published between 2000 and 2018. For each study, Level of Evidence of Effectiveness of ES as well as the Class of Quality for the treatment of different visual pathologies were determined. Results: Thirty-eight articles were included. Studies were grouped according to the pathology treated and the type of stimulation administered. The first group included studies treating pre-chiasmatic pathologies (age-related macular degeneration, macular dystrophy, retinal artery occlusion, retinitis pigmentosa, glaucoma, optic nerve damage, and optic neuropathy) using pre-chiasmatic stimulation; the second group included studies treating both pre-chiasmatic pathologies (amblyopia, myopia) and post-chiasmatic pathologies or brain conditions (hemianopsia, brain trauma) by means of post-chiasmatic stimulation. In the first group, repetitive transorbital alternating current stimulation (rtACS) reached level A recommendation, and transcorneal electrical stimulation (tcES) reached level B. In the second group, both high-frequency random noise stimulation (hf-RNS) and transcranial direct current stimulation (tDCS) reached level C recommendation. Conclusions: Study's findings suggest conclusive evidence for rtACS treatment. For other protocols results are promising but not conclusive since the examined studies assessed different stimulation parameters and endpoints. A comparison of the effects of different combinations of these variables still lacks in the literature. Further studies are needed to optimize existing protocols and determine if different protocols are needed for different diseases.

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Section: Site Of Stimulation Kind Of Clinical Conditions First Authormentioning

confidence: 99%

Non-invasive current stimulation in vision recovery: a review of the literature

Perin

Viganò

Piscitelli

et al. 2019

Restorative Neurology and Neuroscience

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“…In human studies of glaucoma or optic neuropathy, 10 days of toACS results in enhanced visual functions, enlarged visual fields, improved visual acuity, and decreased reaction time to visual stimuli, as well as improved vision-related quality of life ( Fedorov et al, 2011 ; Gall et al, 2011 ; Sabel et al, 2011 ). A recent pilot clinical study shows similar effectiveness of long-term treatment (i.e., 4–6 years) with transcorneal(tco)ACS ( Ota et al, 2018 ). Moreover, tcoACS has also proven to be useful in the treatment of retinitis pigmentosa, wherein recent clinical studies in humans demonstrate both structural and functional improvement ( Schatz et al, 2011 ; Bittner and Seger, 2018 ; Bittner et al, 2018 , however, see Wagner et al, 2017 ).…”

Section: Discussionmentioning

confidence: 93%

“…Moreover, tcoACS has also proven to be useful in the treatment of retinitis pigmentosa, wherein recent clinical studies in humans demonstrate both structural and functional improvement ( Schatz et al, 2011 ; Bittner and Seger, 2018 ; Bittner et al, 2018 , however, see Wagner et al, 2017 ). Several other clinical studies demonstrate that tcoACS can improve visual function (i.e., visual acuity and/or visual field) in patients with various retinal diseases, including retinal artery occlusion, traumatic optic neuropathy, non-arteritic ischemic optic neuropathy, and Best vitelliform macular dystrophy (for a review, see Ota et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

“…Transorbital and transcorneal alternating current stimulation appear to be some of the most promising tools for studying and the rehabilitation of visual dysfunctions. As a result, there is a recent shift in the use of these methods from research laboratories to clinics (for review see Ota et al, 2018 ; Sabel et al, 2019 ). Detailed analysis of the brain activity during stimulation is crucial for elucidating the processes underlying the generation of phenomena associated with mentioned stimulation.…”

Section: Introductionmentioning

confidence: 99%

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Removal of the Sinusoidal Transorbital Alternating Current Stimulation Artifact From Simultaneous EEG Recordings: Effects of Simple Moving Average Parameters

2020

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Alternating current stimulation is a promising method for the study and treatment of various visual neurological dysfunctions as well as progressive understanding of the healthy brain. Unfortunately, due to the current stimulation artifact, problems remain in the context of analysis of the electroencephalography (EEG) signal recorded during ongoing stimulation. To address this problem, we propose the use of a simple moving average subtraction as a method for artifact elimination. This method involves the creation of a template of the stimulation artifact from EEG signal recorded during non-invasive electrical stimulation with a sinusoidal alternating current. The present report describes results of the effects of a simple moving average filtration that varies based on averaging parameters; in particular, we varied the number of sinusoidal periods per segment of the recorded signal and the number of segments used to construct an artifact template. Given the ongoing lack of a mathematical model that allows for the prediction of the “hidden” EEG signal with the alternating current stimulation artifact, we propose performing an earlier simulation that is based on the addition of artificial stimulation artifact to the known EEG signal. This solution allows for the optimization of filtering parameters with detailed knowledge about the accuracy of artifact removal. The algorithm, designed in the MATLAB environment, has been tested on data recorded from two volunteers subjected to sinusoidal transorbital alternating current stimulation. Analysis of the percentage difference between the original and filtered signal in time and frequency domain highlights the advantage of 1-period filtration.

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“…Endogenous bioelectric signals influence virtually every physiological process in the body. Since the proposal, about 100 years ago, of the injury-healing properties of endogenous electric fields, a large number of experimental studies have confirmed the influence of bioelectricity on pathophysiological responses of cells and tissues [25][26][27]. Increasingly adopted in Physical Therapy practice, electrical stimulation (ES) has shown to promote the healing and regeneration of skin, bone, muscle, and nervous tissue [28].…”

Section: Agingmentioning

confidence: 99%

Electrical stimulation inhibits Val-boroPro-induced pyroptosis in THP-1 macrophages via sirtuin3 activation to promote autophagy and inhibit ROS generation

Liu

Gao

Zheng

et al. 2020

Aging

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INTRODUCTION Atherosclerosis (AS), a chronic inflammatory disease of the arterial wall characterized by gradual build-up of arterial plaque, is the main cause of cardiovascular disease (CVD) [1, 2]. Aging is a major, independent risk factor for AS [3]. Macrophages are main components of the inflammatory plaque and promote AS development across its different stages [4-6]. Accumulating data indicates that pyroptosis, a highly inflammatory form of programmed cell death usually triggered in immune cells upon infection by intracellular pathogens, occurs also in AS-associated macrophages and contributes importantly to plaque instability [7, 8]. Therefore, therapies aimed at inhibiting macrophage pyroptosis may reduce the morbidity and mortality associated with AS.

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The Efficacy of Transcorneal Electrical Stimulation for the Treatment of Primary Open-angle Glaucoma: A Pilot Study

Cited by 23 publications

References 21 publications

Non-invasive current stimulation in vision recovery: a review of the literature

Non-invasive current stimulation in vision recovery: a review of the literature

Removal of the Sinusoidal Transorbital Alternating Current Stimulation Artifact From Simultaneous EEG Recordings: Effects of Simple Moving Average Parameters

Electrical stimulation inhibits Val-boroPro-induced pyroptosis in THP-1 macrophages via sirtuin3 activation to promote autophagy and inhibit ROS generation

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