The efficacy of Trypsin: Chymotrypsin preparation in the reduction of oxidative damage during burn injury

Role of antioxidants in the treatment of burn lesions

“…The reason behind this may be the attenuation by the use of antioxidants of vascular permeability, which leads to immediate and continuous loss of substances ranging from water to macromolecules. 34 The results also show that the administration of 75 mg zinc sulphate (group C) to burn patients significantly increased serum zinc levels on day 3 post-burn and on discharge day compared with other groups in this study. This result is also compatible with that obtained by Li et al, 35 who reported that the addition of zinc to the diet of burn patients rapidly raised the level of zinc in the serum.…”

Bio-waste derived dialdehyde cellulose ethers as supports for α-chymotrypsin immobilization

“…The activity studies of the free and immobilized CT were carried out by variation of different parameters such as temperature (25 ºC-45 ºC), pH (2)(3)(4)(5)(6)(7)(8)(9)(10)(11), and BTEE concentration (0.5-2.5 mM). % Relative activity (%RA) was calculated by assigning the value of the highest SA in each set as 100% activity.…”

“…Chymoral Forte has been reported to reduce oxidative damage in burn patients and to assist in wound repair [8,9]. The effect of such drug formulations can further be enhanced by using CT in the immobilized form with enhanced activity and stability.…”

Combined Enzymatic and Antioxidative Treatment Reduces Ischemia-Reperfusion Injury in Rabbit Skeletal Muscle

“…Although trypsin also has antioxidative properties [17], other specific actions of these hydrolytic enzymes have been described. These include (1) reduction of platelet aggregation and lymphocyte adherence [18,19] and activation of protease-activated receptor (PAR)-2 causing vasodilatation [20] by trypsin; and (2) prevention of platelet, leukocyte, and erythrocyte adherence [18,[21][22][23], and fibrinolytic activities dissolving fibrin clots [23,24] by bromelain.…”

“…Bromelain, a cysteine proteinase extracted from pineapples, was described to have antiedematous, antiinflammatory, antithrombotic, and fibrinolytic activities in vitro and in vivo [24]. Trypsin was reported to scavenge OFR and to reduce edema formation and tissue destruction [17].…”