The efficacy of vitamin C infusion in reducing post-intubation sore throat

Abstract

Objective. Vitamin C may be a beneficial adjunct for decreasing sore throat following tracheal intubation. Therefore, the aim of this study was to evaluate the effect of vitamin C infusion on post-intubation sore throat reduction. Methods. This double-blind randomized study was conducted on 70 patients undergoing elective laparoscopic surgery in Shahid Sadoughi Hospital. The patients were allocated into two groups (experimental and control). All patients received 2 mg midazolam and 100 microgram fentanyl citrate premedication. Thirty minutes after induction of anesthesia, 5 mg morphine was given to all patients. In the next step, the experimental group received vitamin C (2 g) mixed with normal saline for the total injection volume of 500 mL during 30 min and those in control group received normal saline without vitamin C.

The Effect of Perioperative Vitamin C on Postoperative Analgesic Consumption: A Meta-Analysis of Randomized Controlled Trials

“…The study characteristics are described in Table 1 . Vitamin C was given perioperatively in six trials [ 5 , 22 , 23 , 24 , 25 , 26 ], and was administered twice a day for three days in another trial [ 27 ]. The routes of administration included intravenous in five trials [ 5 , 22 , 23 , 26 , 27 ] and oral in two trials [ 24 , 25 ].…”

“…Vitamin C was given perioperatively in six trials [ 5 , 22 , 23 , 24 , 25 , 26 ], and was administered twice a day for three days in another trial [ 27 ]. The routes of administration included intravenous in five trials [ 5 , 22 , 23 , 26 , 27 ] and oral in two trials [ 24 , 25 ]. Patient-controlled analgesia (PCA) was used for postoperative pain control in five trials [ 23 , 24 , 25 , 26 , 27 ], while one study used boluses of analgesics [ 5 ] and the other [ 22 ] did not specify the intervention strategies.…”

“…The routes of administration included intravenous in five trials [ 5 , 22 , 23 , 26 , 27 ] and oral in two trials [ 24 , 25 ]. Patient-controlled analgesia (PCA) was used for postoperative pain control in five trials [ 23 , 24 , 25 , 26 , 27 ], while one study used boluses of analgesics [ 5 ] and the other [ 22 ] did not specify the intervention strategies. The follow-up time was 24 h in five trials [ 5 , 22 , 23 , 24 , 25 ], 48 h in one trial [ 26 ], and 72 h in the other trial [ 27 ].…”

“…Patient-controlled analgesia (PCA) was used for postoperative pain control in five trials [ 23 , 24 , 25 , 26 , 27 ], while one study used boluses of analgesics [ 5 ] and the other [ 22 ] did not specify the intervention strategies. The follow-up time was 24 h in five trials [ 5 , 22 , 23 , 24 , 25 ], 48 h in one trial [ 26 ], and 72 h in the other trial [ 27 ]. All procedures were elective and most (i.e., five out of seven) were laparoscopic [ 22 , 23 , 24 , 26 , 27 ].…”

“…The follow-up time was 24 h in five trials [ 5 , 22 , 23 , 24 , 25 ], 48 h in one trial [ 26 ], and 72 h in the other trial [ 27 ]. All procedures were elective and most (i.e., five out of seven) were laparoscopic [ 22 , 23 , 24 , 26 , 27 ]. Two pain scores were adopted for pain severity assessment across the seven studies included, namely, the visual analog scale (VAS) [ 5 , 22 , 25 ] and the verbal numeric rating scale (NRS) [ 23 , 24 , 26 , 27 ].…”