The Efficacy of Washed Microbiota Transplantation on Helicobacter pylori Eradication: A Pilot Study

Abstract

Aim. The fecal microbiota transplantation by washed preparation was recently coined as washed microbiota transplantation (WMT). This pilot study is aimed at exploring the feasibility and efficacy of WMT on Helicobacter pylori eradication. Methods. Consecutive patients who had been treated with WMT for various indications and who were positive for H. pylori infection before WMT treatment but had never received eradication therapy for H. pylori infection were invited to take a follow-up 13C-urea breath test. The associations of demographic, clinical factors, and laboratory indicators for gastric function and intestinal barrier function with the therapeutic effect were determined. Results. A total of 32 eligible patients were included, and the overall H. pylori eradication rate was 40.6% (13/32). Patients with H. pylori eradication had a higher pepsinogen ratio (PGR) than those without ( 13.00 ± 6.97 vs. 8.31 ± 3.733 ; P = 0.02 ). Female patients had a higher, albeit not statistically significant, eradication rate than male patients (53.85% vs. 31.58%; P = 0.208 ). Compared with lower gastrointestinal tract delivery route, middle gastrointestinal tract delivery route seems to be a more suitable way for the treatment of H. pylori infection (58.33% vs 16.67%; P = 0.152 ). There was no significant difference in other demographic and clinical factors between patients with and without H. pylori eradication. Conclusion. H. pylori infection is eradicated in a proportion of patients who have received WMT. An increased pre-WMT PGR appears to be associated with the therapeutic effect. Further studies are required to confirm the efficacy of WMT, especially in combination with currently recommended regimens in randomized controlled trials.

The interplay between Helicobacter pylori and the gut microbiota: An emerging driver influencing the immune system homeostasis and gastric carcinogenesis

“…Washed preparation of FMT was applied in a recent pilot study to eradicate H. pylori infection. The result of this study indicated the potential capacity of FMT in attenuating H. pylori infection to some extent (Ye et al, 2020). Considering the substantial influence of FMT on the intestinal microbiota compared to the gastric microbiota, clinical trials have investigated the impact of FMT on lower gastrointestinal disorders including CRC (Chen et al, 2019).…”

Washed preparation of faecal microbiota changes the transplantation related safety, quantitative method and delivery

“…This public platform works hard to promote the transformation of WMT from clinical benefits to breakthrough in disease cognition. The latest pilot studies indicate the role of WMT on radiation colitis (Ding et al, 2020), complex infections (Dai et al, 2019), recurrent invasive fungal infection (Wu et al, 2021), refractory Helicobacter pylori infection (Ye et al, 2020).…”

Colonic Transendoscopic Enteral Tubing: Route for a Novel, Safe, and Convenient Delivery of Washed Microbiota Transplantation in Children

“…When compared to the adult population, repeated anesthesia, endoscopy, or enema, within short intervals, put children at greater risk; hence, we urgently need to explore a more convenient and safe delivery method. Colonic TET, as a new approach for colon-targeted drug delivery, was published for the first time in 2016 and has since been used in hospitals in China mainland [ 15 , 19 , 26 – 28 ] and China Taiwan since then [ 20 ]. In the present study, TET and WMT were successfully performed in all cases, and WMT or medicine retention time was longer than 1 hour.…”