The Efficacy of Zinc Administration in the Treatment of Primary Dysmenorrhea

Teimoori, Batool; Ghasemi, Marzieh; Hoseini, Zeinab Sadat; Razavi, Maryam

doi:10.5001/omj.2016.21

Cited by 16 publications

(11 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Discussionmentioning

confidence: 99%

“…For example, by inhibiting the release of arachidonic acid and its conversation to prostaglandins, vitamin E may play a role in reducing pain [47,60,61]. Additionally, zinc, besides having antioxidant and anti-inflammatory properties, takes part in reducing prostaglandin metabolism and may decrease the level of pain [62,63]. Furthermore, the intensity of pain perception may be influenced by previous pain experiences, mood, stress, sleeping disorders, the occurrence of premenstrual syndrome, and some cultural and social influences [6,16]; whilst oxidative stress may also be modulated by lifestyle and environmental factors, such as diet, physical activity, alcohol consumption, smoking cigarettes, medical drug abuse, sleep deprivation, stress, or environmental pollution (pesticides, heavy metals, xenoestrogens, etc.)…”

Section: Potential Mechanismmentioning

confidence: 99%

See 1 more Smart Citation

Primary Dysmenorrhea in Relation to Oxidative Stress and Antioxidant Status: A Systematic Review of Case-Control Studies

et al. 2020

View full text Add to dashboard Cite

Primary dysmenorrhea is defined as painful menstrual cramps of uterine origin in the absence of pelvic pathology and is the most common gynecological disorder among women of reproductive age. The aim of this study was to systematically review case-control studies that have investigated the oxidative stress, antioxidant status, and inflammation markers among women with primary dysmenorrhea and controls. The study protocol was registered with PROSPERO (no. CRD42020183104). By searching PubMed and Scopus databases as well as reference lists, six case-control studies with fifteen eligible markers (seven oxidative stress, seven antioxidant status, one inflammation) were included in this review. The quality of the included studies was assessed as medium or high. The systematic review included 175 women with primary dysmenorrhea and 161 controls. The results indicate an elevated level of oxidative stress, especially of lipid peroxidation among dysmenorrheal women. For the antioxidant status, limited evidence was found for a lower status among primary dysmenorrhea women, and only one study examined one inflammation marker (hs-CRP), which makes it impossible for such a conclusion. To establish whether oxidative stress, antioxidant status or inflammation participate in the pathophysiology of primary dysmenorrhea, high-quality studies with larger study groups and clear case definitions are needed.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Potential Mechanismmentioning

confidence: 99%

Primary Dysmenorrhea in Relation to Oxidative Stress and Antioxidant Status: A Systematic Review of Case-Control Studies

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In this study, 3 clinical trials were included, administration of zinc micronutrient also significantly reduced dysmenorrhea. In a study by Zekavat et al, 36 50 mg/day zinc was used on the first 3 days for 3 cycles and in the study by Kashefi et al, 37 220 mg zinc (3 times a day to 4 days) was used for 2 months, and in Teimoori et al,'s study 38 250 mg/day zinc and Mefenamic acid capsules (250) were administered for 3 menstrual cycles. Since mefenamic acid was used with zinc as a pain killer in Teimoori et al,'s study, the synergic effect of mefenamic acid may illustrate a significant reduction of pain severity.…”

Section: Zincmentioning

confidence: 99%

The Effect of Micronutrients on Pain Management of Primary Dysmenorrhea: a Systematic Review and Meta‐Analysis

et al. 2020

View full text Add to dashboard Cite

Introduction: Primary dysmenorrhea is considered as one of the main problems in women. This review study aimed to characterize the effect of micronutrients on primary dysmenorrhea. Methods: In this systematic and meta‐analysis study, the articles were searched at Cochrane library, PubMed, Scopus, Web of Science databases. The searching process was conducted with the key terms related to dysmenorrhea and micronutrients. Risk of bias assessment was performed, using Rev Man 5.3 software. In view of the heterogeneity of some of the studies, they were analyzed, using a qualitative method (n=10), and only 6 studies were included in Meta analyze. STATA statistical software version 11 was used for the analysis. Results: In this study, finally 16 clinical trials were investigated. Most micronutrients studied in the relevant articles had anti-inflammatory and analgesic properties with a desirable effect on dysmenorrhea pain relief. Vitamins (K, D, B1, and E) and calcium, magnesium, zinc sulfate and boron contributed effectively to dysmenorrhea pain management. Two months after the intervention, there was a significant mean decrease in the pain score for the vitamin D intervention group (SMD: -1.02, 95% CI: -1.9 to – 0.14, P =0.024) , as well as in the vitamin E intervention group compared to placebo group (SMD: - 0.47,95% CI:-0.74 to – 0.2, P = 0.001). Conclusion: Despite the paucity of related research, the studies indicated the potential effects of micronutrients on reducing the pain severity in primary dysmenorrhea. But more studies are needed to confirm the safety and effectiveness of various types of micronutrients on primary dysmenorrhea.

show abstract

“…Reduction of pain severity was noted independently of zinc dose (in all used doses and without any adverse effects) administered for 3–6 days starting before or during menstrual cycle. It seems that zinc dose above 30 mg/day does not improve the efficacy of supplementation [ 88 , 91 ]. This is particularly important, because the daily dose of zinc in dietary supplements, according to EFSA and IOM recommendations, should not exceed 25 and 40 mg, respectively [ 9 , 10 ].…”

Section: Resultsmentioning

confidence: 99%

“…This is particularly important, because the daily dose of zinc in dietary supplements, according to EFSA and IOM recommendations, should not exceed 25 and 40 mg, respectively [ 9 , 10 ]. Interestingly, greater pain alleviation was observed after simultaneous administration of zinc with mefenamic acid than with mefenamic acid alone [ 91 ].…”

Section: Resultsmentioning

confidence: 99%

The Role of Zinc in Selected Female Reproductive System Disorders

et al. 2020

View full text Add to dashboard Cite

Zinc is an essential microelement that plays many important functions in the body. It is crucial for the regulation of cell growth, hormone release, immunological response and reproduction. This review focuses on its importance in the reproductive system of women of reproductive and postmenopausal ages, not including its well described role in pregnancy. Only recently, attention has been drawn to the potential role of zinc in polycystic ovary syndrome (PCOS), dysmenorrhea, or endometriosis. This review is mainly based on 36 randomized, controlled studies on reproductive, pre- and post-menopausal populations of women and on research trying to explain the potential impact of zinc and its supplementation in the etiology of selected female reproductive system disorders. In women with PCOS, zinc supplementation has a positive effect on many parameters, especially those related to insulin resistance and lipid balance. In primary dysmenorrhea, zinc supplementation before and during each menstrual cycle seems to be an important factor reducing the intensity of menstrual pain. On the other hand, little is known of the role of zinc in endometriosis and in postmenopausal women. Therefore, further studies explaining the potential impact of zinc and its supplementation on female reproductive system would be highly advisable and valuable.

show abstract

The Efficacy of Zinc Administration in the Treatment of Primary Dysmenorrhea

Abstract: The use of a zinc supplement in combination with mefenamic acid was superior in reducing primary dysmenorrhea compared to mefenamic acid alone.

Cited by 16 publications

References 25 publications

Primary Dysmenorrhea in Relation to Oxidative Stress and Antioxidant Status: A Systematic Review of Case-Control Studies

Primary Dysmenorrhea in Relation to Oxidative Stress and Antioxidant Status: A Systematic Review of Case-Control Studies

The Effect of Micronutrients on Pain Management of Primary Dysmenorrhea: a Systematic Review and Meta‐Analysis

The Role of Zinc in Selected Female Reproductive System Disorders

Contact Info

Product

Resources

About