The Efficiency of AuNPs in Cancer Cell Targeting Compared to Other Nanomedicine Technologies Using Fuzzy PROMETHEE

et al. 2023

Pharmaceutics

The accumulation of pathologically misfolded tau is a feature shared by a group of neurodegenerative disorders collectively referred to as tauopathies. Alzheimer’s disease (AD) is the most prevalent of these tauopathies. Immunohistochemical evaluation allows neuropathologists to visualize paired-helical filaments (PHFs)—tau pathological lesions, but this is possible only after death and only shows tau in the portion of brain sampled. Positron emission tomography (PET) imaging allows both the quantitative and qualitative analysis of pathology over the whole brain of a living subject. The ability to detect and quantify tau pathology in vivo using PET can aid in the early diagnosis of AD, provide a way to monitor disease progression, and determine the effectiveness of therapeutic interventions aimed at reducing tau pathology. Several tau-specific PET radiotracers are now available for research purposes, and one is approved for clinical use. This study aims to analyze, compare, and rank currently available tau PET radiotracers using the fuzzy preference ranking organization method for enrichment of evaluations (PROMETHEE), which is a multi-criteria decision-making (MCDM) tool. The evaluation is based on relatively weighted criteria, such as specificity, target binding affinity, brain uptake, brain penetration, and rates of adverse reactions. Based on the selected criteria and assigned weights, this study shows that a second-generation tau tracer, [18F]RO-948, may be the most favorable. This flexible method can be extended and updated to include new tracers, additional criteria, and modified weights to help researchers and clinicians select the optimal tau PET tracer for specific purposes. Additional work is needed to confirm these results, including a systematic approach to defining and weighting criteria and clinical validation of tracers in different diseases and patient populations.

Section: Adverse Reactionsmentioning

confidence: 99%

A Multi-Criteria Decision Aid Tool for Radiopharmaceutical Selection in Tau PET Imaging

Ozsahin

Onakpojeruo²,

et al. 2023

Pharmaceutics

“…In this way, fuzzy logic and its applications enable decision makers to analyze ambiguous decision models and assess uncertain data, more concretely than the traditional methods. The fuzzy PROMETHEE technique is also a hybrid model that is based on the evaluation of variable systems, and it has applications in a wide range of sectors such as architecture, sociology, engineering, medicine, biomedicine, and so on [25]. The PROMETHEE technique is based on the simultaneous evaluation of selected alternatives with regard to factors selected as criteria.…”

Section: Fuzzy Promethee and Applicationmentioning

confidence: 99%

Comparative Evaluation of 3D Filaments, Used in Additive Manufacturing of Biomedical Tools; Using Fuzzy Promethee.

Duwa

Onakpojeruo

et al. 2022

Preprint

Self Cite

The additive manufacturing technique is currently revolutionizing the healthcare industry. This technology utilizes modern approaches to develop advanced medical equipment and artificial body tissues. The 3D filament is regarded as one of the major components of the 3D printing technique. These filaments have peculiar characters to print different objects. Similarly, hospital and biomedical tools, such as syringes, catheters, insulin pens, and surgical gloves, for instance, are produced using non-biodegradable plastics, which could be toxic and unsafe to the environment. Therefore, there is a need to produce these biomedical tools using safe and environmentally friendly filaments. Therefore, this study evaluates and compares the major 3D filaments used in Fused deposition modeling, using a multi-criteria decision-making technique called the fuzzy preference ranking organization method for enrichment evaluations (PROMETHEE). The variables were evaluated based on parameters such as strength, warp, flexibility, heat resistance, biodegradability, average cost, resistance to UV, food safety, print temperature, speed, and ease of print. The result recorded PLA with a net flow of 0.0316 as the preferred and extensively used 3D printing filaments in additive manufacturing of biomedical tools based on applied parameters/set preference, selected criteria, and important weights allocated to the selected criteria. PC is second with a net flow of 0.0069. In contrast, TPE ranked least with a negative net flow result of -0.0327.

“…The idea was to create a middle ground in the presence of uncertainty when making di cult decisions that have possibilities that differ from yes or no [1][4] [38]. Therefore, F-PROMETHEE is a reliable decision-making tool to compare well-structured linguistic fuzzy data [4] [35], [36], [39] [40], [41]. The application of F-PROMETHEE is well detailed in a study by Ozsahin et al [4].…”

Section: Application Of F-promethee Technique To Studymentioning

confidence: 99%

Evaluation of the Treatment Alternatives for Spinal Cord Tumors Using Analytical Evaluation Models

Onakpojeruo¹,

Ozsahin

et al. 2022

Preprint

Self Cite

Spinal cord tumors are the abnormal mass of cells that grow, divide and multiply uncontrollably in the spinal cord. Treatment of spinal cord tumors depends on the type, the affected site, the level of complications, and the spread levels. The treatment of spinal cord tumors is not limited to conventional chemotherapy, radiotherapy, and surgery methods but also other techniques, including immunotherapy, targeted therapy, proton therapy, interventional radiology, radiofrequency ablation, and cryoablation. This study compares the treatment alternatives for spinal cord tumors using a multi-criteria decision-making technique called the fuzzy preference ranking organization method for enrichment evaluations (PROMETHEE). These alternatives are evaluated based on certain criteria, which include reliability, use in isolation, cost of treatment, complications during use, side effects, pain relief rate, recovery period, session duration, necrotic tumor rate, and survival rate. The results show that radiofrequency ablation with the highest net outranking flow (0.2604) was the most preferred treatment alternative for the spinal cord tumor. Followed by cryoablation (with 0.1370 net flow), and then, surgery with (-0.0415 net flow). This study indicates that the fuzzy PROMETHEE technique is very effective in producing solutions for health care decision-makers facing problems of uncertainty and can be improved with the availability of more alternatives and criteria based on the specific needs of the patients individually.