The efficiency of metal, metal oxide, and metalloid nanoparticles against cancer cells and bacterial pathogens: different mechanisms of action

Alavi, Mehran; Rai, Mahendra; Martínez, Fleming; Kahrizi, Danial; Khan, Haroon; Menezes, Irwin Rose Alencar de; Coutinho, Henrique Douglas Melo; Costa, José G. M.

doi:10.55705/cmbr.2022.147090.1023

Cited by 68 publications

(47 citation statements)

References 39 publications

(41 reference statements)

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“…As shown in Figure 2, other components of the bacterial envelope, including capsule, fimbriae, pilus, flagellum, teichoic acid and lipoteichoic acid of Grampositive bacteria, and lipopolysaccharide of Gram-negative bacteria could be targeted by functionalized SiO2NPs [68]. In order to achieve synergistic antimicrobial activity against bacteria or viruses, antibacterial or antiviral agents such as metals, metal oxide NPs or antibiotics can be employed to functionalize SiO2NPs to produce reactive oxygen species (ROS) that can then damage biological macromolecules (Figure 3e) [70][71][72]. The use of organosilane-based coupling agents is the main way to prepare different derivatives of SiO2NPs (Figure 3a-3d) [58,73].…”

Section: Surface Modification By Sio2 Npsmentioning

confidence: 99%

Surface modification of SiO2 nanoparticles for bacterial decontaminations of blood products

Alavi¹,

Hamblin²,

Mozafari³

et al. 2022

Cell. Mol. Biomed. Rep.

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Section: Surface Modification By Sio2 Npsmentioning

confidence: 99%

Surface modification of SiO2 nanoparticles for bacterial decontaminations of blood products

Alavi¹,

Hamblin²,

Mozafari³

et al. 2022

Cell. Mol. Biomed. Rep.

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“…Treatment of S. pneumoniae infections should be based on the site of infection and the underlying disease, and the high resistance to trimethoprim/sulfamethoxazole and rifampicin in our study showed that these two antibiotics do not help treat these infections. One of the main reasons for the high resistance of Streptococcus pneumoniae and other bacterial species to these antibiotics is their excessive use in lung infections, sinusitis, and middle ear infections, as well as over-the-counter sales in pharmacies (26). It may also be due to the high prevalence of brucellosis and tuberculosis and the over-use of antibiotics in treating these two diseases, especially at a young age.…”

Section: Resultsmentioning

confidence: 99%

Determining the frequency of Streptococcus pneumoniae carriers and its microbial resistance in children

Lei¹,

Wang²

2022

Cell Mol Biol (Noisy-le-grand)

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Streptococcus pneumoniae is a common cause of bacterial infections of the respiratory system, middle ear infection, bacteremia, meningitis, and pneumonia, especially in children. Due to the lack of information about the frequency and resistance of Streptococcus pneumoniae to antibiotics, the present study was performed to determine the frequency of carriers of Streptococcus pneumoniae and its microbial resistance in children. For this purpose, the current descriptive cross-sectional study was conducted from November to March 2020 on 554 children aged 2-12 years in kindergartens and schools. This study collected samples with a sterile swab from the nasopharyngeal region, transported them to the laboratory by a transport medium, and then cultured them on an agar culture medium. After isolation, confirmatory tests and antibiotic susceptibility were performed. The results were analyzed using SPSS16 software and interpreted according to Mann Whitney U and Chi-Square Tests. Streptococcus pneumoniae was found in 15% of samples, and the antibiotic resistance of the isolates to the antibiotics azithromycin, amoxicillin, rifampicin, amoxicillin-clavulanic acid, trimethoprim/Sulfamethoxazole, and ceftriaxone were 63.9%, 56.6%, 41%, 37.3%, 37.3%, and 3.6%, respectively. Also, 31.1% of the isolates were not resistant to any antibiotics. According to the results, excessive use of antibiotics has led to high resistance to azithromycin, amoxicillin, amoxicillin/clavulanic acid, and trimethoprim/Sulfamethoxazole, which indicates an increased risk of refractory infectious diseases. For this reason, it is necessary to adequately educate physicians and the general public about the overuse of antibiotics.

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“…However, the exact mechanism has not been completely defined. In review studies by Alavi et al [ 15 , 16 ] on antibacterial properties of NPs, various mechanisms were pointed out, including increase in the permeability of antibiotics into the cells, pore creation and membrane destruction, prevention of biofilm formation, inactivation of electron transfer chain, production of reactive oxygen species (ROS), denaturation of macromolecules, and effect on cellular signals. Taken together, more potential of ZnONPs than CCCP in dye accumulation, suggests that it can be a suitable candidate for anti-efflux studies in future.…”

Section: Discussionmentioning

confidence: 99%

Determination of efflux activity in Enterococci by Hoechst accumulation assay and the role of zinc oxide nanoparticles in inhibition of this activity

et al. 2022

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Background Contribution of efflux pumps in development of antimicrobial resistance has been largely addressed in Gram negative and to a much lesser extent in Gram positive bacteria. Measuring accumulation of Hoechst (H) dye is known as a safe and rapid method for monitoring efflux activity in bacteria. Antimicrobial effects of metal nanoparticles have been attributed in part to inhibition of efflux pumps. This study aimed to first determine efflux activity in enterococci by Hoechst accumulation assay, and to second characterize the role of zinc oxide nanoparticles (ZnONPs) in inhibition of these pumps. Results Increased accumulation of Hoechst dye showed more potential of ZnONPs in efflux inhibition compared with CCCP. H33258 represented more suitability for accumulation studies in enterococci. Two to six-fold reduction in minimum inhibitory concentration (MIC) values of antimicrobial agents in the presence of ZnONPs was observed. Conclusions Efflux activity in enterococcal strains can be measured by H33258 accumulation assay. Application of ZnONPs as an efflux inhibitor, may rejuvenate the use of conventional antimicrobial agents against these bacteria.

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The efficiency of metal, metal oxide, and metalloid nanoparticles against cancer cells and bacterial pathogens: different mechanisms of action

Cited by 68 publications

References 39 publications

Surface modification of SiO2 nanoparticles for bacterial decontaminations of blood products

Surface modification of SiO2 nanoparticles for bacterial decontaminations of blood products

Determining the frequency of Streptococcus pneumoniae carriers and its microbial resistance in children

Determination of efflux activity in Enterococci by Hoechst accumulation assay and the role of zinc oxide nanoparticles in inhibition of this activity

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