The efficiency of remote ischemic preconditioning on serum cystatin C-based acute kidney injury in patients undergoing coronary angiography; a randomized controlled trial

Moradkhani, Azadeh; Samimagham, Hamid Reza; Tamaddondar, Mohammad; Farshidi, Hossein; Khayatian, Mahmood; Soleimani, Sanaz

doi:10.34172/npj.2021.09

Cited by 3 publications

(2 citation statements)

References 38 publications

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“…Scholars such as Al-Beladi [ 10 ] have found through experiments that serum Cys C can diagnose acute renal injury 1.5 d–2 d earlier than SCr. Moradkhani et al [ 11 ] also confirmed that Cys C can be used as an early diagnostic indicator of acute kidney injury associated with sepsis in children. In this study, we divided 67 children with severe sepsis into three groups according to the time interval from the time point of serum Cys C >15 mg/L to the time point of CBP initiation.…”

Section: Discussionmentioning

confidence: 95%

Serum Cystatin C Level Monitoring for Intervention Opportunity of CBP in Children with Severe Sepsis

Wang

Tao

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. The aim of this study is to investigate the instruction value of the serum cystatin C (Cys C) level monitoring for intervention opportunity of continuous blood purification technology (CBP) in children with severe sepsis. Methods. 67 children with severe sepsis in the pediatric intensive care unit (PICU) with CBP treatment were retrospectively selected from May 2016 to April 2020. According to the time intervals between the time point of serum Cys C level began to increase (>15 mg/L) and the time point of CBP began, all children were divided into group A (<24 h, 29 cases), group B (24–48 h, 22 cases), and group C (>48 h, 16 cases). The children’s general characteristics, vital signs, biochemical parameters, acute physiology and chronic health evaluation (APACHE II), and sequential organ failure assessment (SOFA) scores were evaluated. The influence factors of prognosis of children with severe sepsis were analyzed by multivariate regression analysis. Results. The intervals between the time point of PICU hospitalization and the time point of CBP began and the times of CBP in group A were significantly more than those in group B and C P < 0.05 . There was no statistically significant duration of CBP among three groups P > 0.05 . After follow-up of 28 d, there was no significant difference on the occurrence of coagulation disorders and hypovolemic shock induced by CBP among three groups P > 0.05 . However, the mortality of children in group A was lower than that in group C P < 0.05 . Children in group A had lower APACHE II scores, SOFA scores, serum K+, blood urea nitrogen (BUN), serum creatine (SCr), partial pressure of carbon dioxide (PCO2), and higher partial pressure of oxygen (PO2) than those of children in group C after CBP. P < 0.05 . SOFA scores ≥5 after CBP treatment and the time intervals between the time point of serum Cys C level began to increase (>15 mg/L) and the time point of CBP began ≥24 h were the independent influence factors on the prognosis by multivariate regression analysis. Conclusion. There are significant evidences that continuous blood purification technology within 24 h of serum Cys C level may better control the condition of children with severe sepsis.

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Section: Discussionmentioning

confidence: 95%

Serum Cystatin C Level Monitoring for Intervention Opportunity of CBP in Children with Severe Sepsis

Wang

Tao

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Some studies have found that Cys-C has a diagnostic and predictive role in sepsis complicated with acute kidney injury (SA-AKI). Cys-c can diagnose SA-AKI in advance than creatinine and is more suitable as a biomarker of sepsis and complications than creatinine (Figure 3) [28].…”

Section: Severe Infectious Inflammatory Diseasementioning

confidence: 99%

An Overview about the Relationship between Cystatin C and Inflammatory Diseases

Huang¹

2022

austinjanalpharmchem

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Cystatin C (Cys-C) is a protease inhibitor that can be produced by nuclear cells in the human body. Its principal function is to inhibit the activity of various cysteine proteases in vivo. In addition, Cys-C also plays an essential role in regulating antigen presentation, extracellular matrix degradation, and the balance of protein production and decomposition in living cells. Cys-C is involved in the pathophysiological processes of chronic inflammatory diseases, including cardiovascular, cerebrovascular, and respiratory diseases. This article reviews the effects of Cys-C on chronic inflammatory diseases and its therapeutic prospects.

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Effect of remote ischemic preconditioning, nicorandil, and trimetazidine in contrast-induced nephropathy: a network meta-analysis of randomized controlled trials

Gao,

Li,

Sun

et al. 2024

Renal Failure

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Introduction Contrast-induced nephropathy (CIN) is a potential complication associated with the administration of intravenous contrast agents. The objective of this study was to evaluate the effectiveness of remote ischemic preconditioning (RIPC) and two pharmacological interventions in preventing CIN. Methods Randomized controlled trials (RCTs) examining the efficacy of RIPC, nicorandil, and trimetazidine in treating CIN were searched within databases such as PubMed, Cochrane Library, Embase, and Web of Science. The primary outcome was the incidence of CIN. The consistency model was used to address heterogeneity and enhance model fit. The assessment of consistency between direct and indirect evidence was conducted through the node-splitting method. Posterior probability estimates and surface under the cumulative ranking area (SUCRA) ranked interventions based on their effectiveness in preventing CIN. The Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) framework was used to grade the quality of evidence. Results Based on hydration therapy, RIPC, nicorandil, and trimetazidine all showed prophylactic effects on CIN compared to control groups. The SUCRA results showed that RIPC (SUCRA = 37.7%, PrBest = 0.4%), nicorandil (SUCRA = 91.2%, PrBest = 74.7%), and trimetazidine (SUCRA = 71.0%, PrBest = 24.9%). However, there were no significant differences between the nicorandil, RIPC, and trimetazidine groups. Subgroup analysis suggested that there was still a protective effect in populations with mean estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73 m 2 or with a high prevalence of diabetes mellitus. Conclusions Nicorandil, trimetazidine, and RIPC all showed renal protective effects. Based on hydration, nicorandil, trimetazidine, and RIPC may show better prophylaxis against CIN than hydration alone after intravenous contrast administration.

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The efficiency of remote ischemic preconditioning on serum cystatin C-based acute kidney injury in patients undergoing coronary angiography; a randomized controlled trial

Cited by 3 publications

References 38 publications

Serum Cystatin C Level Monitoring for Intervention Opportunity of CBP in Children with Severe Sepsis

Serum Cystatin C Level Monitoring for Intervention Opportunity of CBP in Children with Severe Sepsis

An Overview about the Relationship between Cystatin C and Inflammatory Diseases

Effect of remote ischemic preconditioning, nicorandil, and trimetazidine in contrast-induced nephropathy: a network meta-analysis of randomized controlled trials

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