2021
DOI: 10.1016/j.ejphar.2021.174403
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The Egr-1/miR-15a-5p/GPX4 axis regulates ferroptosis in acute myocardial infarction

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Cited by 67 publications
(51 citation statements)
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“…SREBF1 [744], TP53 [745] and EGR1 [746] have been revealed to be highly expressed in CNS disorders, but these genes might be involved in the progression of COVID-19. SREBF1 [747], ELF5 [748], TP53 [749], EGR1 [750], E2F6 [751] and STAT3 [752] have been demonstrated to function in cardiovascular diseases, but these genes might be involved in the progression of COVID-19. ELK1 [753], EGR1 [754] and STAT3 [755] plays a key role in the development of the lung diseases, but these genes might be involved in the progression of COVID-19.…”
Section: Discussionmentioning
confidence: 99%
“…SREBF1 [744], TP53 [745] and EGR1 [746] have been revealed to be highly expressed in CNS disorders, but these genes might be involved in the progression of COVID-19. SREBF1 [747], ELF5 [748], TP53 [749], EGR1 [750], E2F6 [751] and STAT3 [752] have been demonstrated to function in cardiovascular diseases, but these genes might be involved in the progression of COVID-19. ELK1 [753], EGR1 [754] and STAT3 [755] plays a key role in the development of the lung diseases, but these genes might be involved in the progression of COVID-19.…”
Section: Discussionmentioning
confidence: 99%
“…A previous investigation found that altered expression of STAT3 [295], STAT4 [296], FOXA2 [297], SOX2 [298], EGR1 [299], SMAD1 [300] and VDR (vitamin D receptor) [301] were associated with type 2 diabetes mellitus. Bao et al [302], Reid et al [303], Tian et al [304], Liang et al [305], Fan et al [306] and VDR (vitamin D receptor) in patients with renal diseases.. In this investigation, STX7, RAD18, YWHAZ, RPS15A, RAD51B, hsa-mir-4471, hsa-mir-7159-3p, hsa-mir-4478, hsa-mir-6818-5p, hsa-mir-3150b-3p, hsa-mir-518f-5p, hsa-mir-940, hsa-mir-3666 and RAD21 were might be potential novel modulators of T1DM.…”
Section: Discussionmentioning
confidence: 99%
“…A previous investigation found that altered expression of STAT3 [295], STAT4 [296], FOXA2 [297], SOX2 [298], EGR1 [299], SMAD1 [300] and VDR (vitamin D receptor) [301] were associated with type 2 diabetes mellitus. Bao et al [302], Reid et al [303], Tian et al [304], Liang et al [305], Fan et al [306], Wang et al [307] and Gonzalez-Parra et al [308] showed that STAT3, STAT4, FOXM1, SOX2, EGR1, SMAD1 and VDR (vitamin D receptor) might play an important role in regulating the genetic network related to the occurrence and development of cardiovascular complications. The altered expression of STAT3 [309], FOXM1 [310], SMAD1 [311] and VDR (vitamin D receptor) [312] might be related to the progression of hypertension.…”
Section: Discussionmentioning
confidence: 99%
“…Studies also indicate that other signaling molecules such as NADPH oxidase 4 (NOX4) and GPX4 regulate ferroptosis and thus affect heart disease (Supplementary Table S3). Ferroptosis is increasingly considered a potential cause of cardiovascular morbidity, and inhibition of ferroptosis represents a new strategy for these patients (Liu et al, 2018a;Bai et al, 2018;Chen et al, 2019;Fang et al, 2019;Feng et al, 2019;Fan et al, 2021).…”
Section: Ferroptosis Pathways In Cardiovascular Diseasesmentioning
confidence: 99%