The electrochemistry of neurotransmitters at conducting organic polymer electrodes: electrocatalysis and analytical applications

Mark, Harry B.; Atta, Nada F.; Ma, Yuan; Petticrew, K.L.; Zimmer, H.; Shi, Yining; Lunsford, Suzanne K.; Rubinson, Judith F.; Galal, Ahmed M.

doi:10.1016/0302-4598(95)01846-7

Cited by 90 publications

(36 citation statements)

References 43 publications

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“…In all cases, the oxidation current increased with the potential scan rate, whereas peak potential shifted towards more positive values. Linear log i p vs. log v plots were obtained with slope values close to 0.5, thus indicating that the oxidation current was diffusion controlled, which is consistent with results found for other organic compounds at these modi®ed microelectrodes [19], as well as at P3MT-coated Pt and GC electrodes of conventional size [17].…”

Section: Voltammetry At P3mt-coated Cfmessupporting

confidence: 51%

“…Electrodes of conventional size modi®ed with Na®on [15] and conducting polymers such as polypyrrole or polythiophene [16] have been employed to improve selectivity for the determination of catecholamines. In particular, Pt and glassy carbon (GC) electrodes coated with poly(3-methylthiophene) (P3MT) exhibited a good electrocatalytic ability towards the oxidation of these compounds [17]. Recently, the electrochemical behavior of different molecules of biological interest, including catecholamines, were checked at a P3MT-coated Pt microdisk electrode [18].…”

Section: Introductionmentioning

confidence: 99%

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Microcylinder Polymer Modified Electrodes as Amperometric Detectors for Liquid Chromatographic Analysis of Catecholamines

et al. 1999

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The use of cylindrical carbon ®ber microelectrodes (CFMEs) of various mm in length modi®ed with poly(3-methylthiophene) (P3MT) ®lms as amperometric microsensors for the LC-EC detection of catecholamines is reported. Cyclic voltammetry at the modi®ed microelectrodes of dopamine, epinephrine, catechol, serotonin and ascorbic acid showed electrocatalytic ability of the modi®ed surface. This allowed the application of low potentials (0.35 V) for the amperometric detection of the above-mentioned compounds. Flow injection measurements carried out using a 2:98 vav methanol:0.025 mol L À1 H 2 PO 4 À aHPO 4 2À solution of pH 7.0, showed no evidence of fouling of the modi®ed microelectrode surface. No cleaning or regeneration treatment was needed when working with the same polymer modi®ed microelectrode during the whole working day. Moreover, RSD values for i p lower than 5 % were obtained when amperometric measurements were carried out with three different P3MT-coated CFMEs. These modi®ed microelectrodes have also shown to be suitable for amperometric detection in HPLC. A mobile phase composed of 2:98 % methanol:phosphate buffer solution of pH 7.0 allowed a good separation of mixtures of ascorbic acid, epinephrine, dopamine, serotonin and catechol with detection limits ranging between 14 and 48 pmol. Furthermore, as an application, the determination of those compounds in spiked serum samples, was accomplished with good results.

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Section: Voltammetry At P3mt-coated Cfmessupporting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Microcylinder Polymer Modified Electrodes as Amperometric Detectors for Liquid Chromatographic Analysis of Catecholamines

et al. 1999

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“…Fouling of the electrode surface has long been a serious problem in electrochemical determinations of many organic compounds. Polymer coating of the surface of the electrode substrate helped to alleviate this problem [8].…”

Section: Introductionmentioning

confidence: 99%

Electrochemistry and Characterization of Some Organic Molecules at “Microsize” Conducting Polymer Electrodes

Galal

1998

Electroanalysis

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Poly(3-methylthiophene) is electrochemically deposited on platinum microsize substrate. Two methods are used for the electropolymerization including applying constant potential of 1.65 V to 1.75 V, or cycling the working electrode between two potential limits from ¹0.2 V to 1.65-1.80 V (vs. Ag/AgCl). The resulting conducting polymer electrode is used for the determination of some organic molecules of biological interest. The resolution of the voltammetric peaks obtained for the determination of a mixture of three components analyte is a function of the method used for electrodeposition of the polymer film. The electrochemical data obtained at the microsize conducting polymer electrode are compared to those obtained at ''conventional''-size polymer electrodes. The morphology of the microsize polymer electrode is examined using scanning electron microscopy. The data suggest great promise for using microsize polymer electrodes as electrochemical sensor for biomedical applications.

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“…Among the numerous polymeric materials developed and studied over the past few decades, polyanilines, polypyrroles and polythiophenes constitute an important class [19]. Among these, polythiophenes have received a significant amount of attention as electrode modifiers for a variety of applications in organic light-emitting devices, sensors, polymer batteries, electrochromic windows, etc.…”

Section: Introductionmentioning

confidence: 99%

Determination of Uric Acid in the Presence of Ascorbic Acid Using Poly(3,4-ethylenedioxythiophene)-Modified Electrodes

Mathiyarasu

Phani

et al. 2005

Electroanalysis

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A poly(3,4-ethylenedioxythiophene) (PEDOT) modified glassy carbon electrode (GCE) was used to determine uric acid in the presence of ascorbic acid at physiological pH facilitating a peak potential separation of ascorbic acid and uric acid oxidation (ca. 365 mV), which is the largest value reported so far in the literature. Also, an analytical protocol involving differential pulse voltammetry has been developed using a microchip electrode for the determination of uric acid in the concentration range of 1 to 20 mM in presence of excess of ascorbic acid.

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The electrochemistry of neurotransmitters at conducting organic polymer electrodes: electrocatalysis and analytical applications

Cited by 90 publications

References 43 publications

Microcylinder Polymer Modified Electrodes as Amperometric Detectors for Liquid Chromatographic Analysis of Catecholamines

Microcylinder Polymer Modified Electrodes as Amperometric Detectors for Liquid Chromatographic Analysis of Catecholamines

Electrochemistry and Characterization of Some Organic Molecules at “Microsize” Conducting Polymer Electrodes

Determination of Uric Acid in the Presence of Ascorbic Acid Using Poly(3,4-ethylenedioxythiophene)-Modified Electrodes

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