The electrospray mass spectra of phosphoric acid, methylphosphonic acid and its alkyl esters, and their complexes with alkali and alkali earth metal ions

Borrett, Veronica; Colton, R.; Traeger, John C.

doi:10.1255/ejms.146

Cited by 34 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, Borrett and co-workers reported that phosphoric acid forms 1:1 to 1:3 adducts with sodium ions. 19 On the other hand, the neutral metal bipyridine complexes which have several carbonyl ligands presented here form only 1:1 adduct, even when the sodium ions are added in large excess. This observation 288 ANALYTICAL SCIENCES APRIL 1998, VOL.…”

Section: Es-mass Spectra Measurementsmentioning

confidence: 79%

“…Therefore, it is possible to know the molecular mass of the original neutral complex by subtracting the sodium mass from the observed m/z value. Small peaks of sodium adducts were often observed in ES-mass spectra of neutral compounds containing oxygen 19 or nitrogen atoms 4 , where the sodium ions interact with the lone-pair electrons on these atoms of the compounds. For example, Borrett and co-workers reported that phosphoric acid forms 1:1 to 1:3 adducts with sodium ions.…”

Section: Es-mass Spectra Measurementsmentioning

confidence: 99%

See 1 more Smart Citation

Electrospray Mass Spectrometric Detection of Neutral Metal Bipyridine Complexes Using Sodium Ions and Its Application in the Analysis of a Photochemical Ligand Substitution Reaction

et al. 1998

View full text Add to dashboard Cite

Sodium ions can be used as efficient chemical ionization agents in electrospray mass spectrometry of a wide variety of neutral metal bipyridine complexes. This ionization method was successfully permitted the identification of a neutral metal complex generated during the photochemical ligand substitution reaction: [Re(bpy)(CO)3{P(OEt)3}] + +Cl -® Re(bpy)(CO)2{P(OEt)3}Cl+CO by sodium adduct formation to produce an electrospray-active species [Re(bpy)(CO)2{P(OEt)3}Cl+Na] + .

show abstract

Section: Es-mass Spectra Measurementsmentioning

confidence: 79%

Section: Es-mass Spectra Measurementsmentioning

confidence: 99%

Electrospray Mass Spectrometric Detection of Neutral Metal Bipyridine Complexes Using Sodium Ions and Its Application in the Analysis of a Photochemical Ligand Substitution Reaction

et al. 1998

View full text Add to dashboard Cite

show abstract

“…This phenomenon has been reported previously for these compounds. 7 The [MH-H 2 O] + ion predominated for TDG at cone voltages greater than 20. For TDG sulfoxide and TDG sulfone at a cone voltage of 20, the base peaks (most abundant ion) were sodium adducts of the molecule.…”

Section: Resultsmentioning

confidence: 99%

Analysis of the degradation compounds of chemical warfare agents using liquid chromatography/mass spectrometry

Smith

Shih

2001

J. Appl. Toxicol.

View full text Add to dashboard Cite

The analysis of the degradation products of chemical warfare (CW) agents has been a challenge to analysts. The low volatility of these compounds makes them unsuitable for direct gas chromatography analysis without prior derivatization. Lack of a chromophore causes difficulties with classic detection methods after liquid chromatography separation. With the recent development of various interfaces that allow for the introduction of a liquid solvent stream into the mass spectrometer, the task of directly analyzing these compounds has become easier. For this report, we examined three different liquid chromatography/mass spectrometry (LC/MS) interfaces for their suitability for the analysis of CW degradation compounds. The interface types examined were particle beam electron impact ionization (PBI), electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI). Several alkylphosphonates and thiodiglycol analogs that are produced from the degradation of organophosphorus nerve agents and sulfur mustard, respectively, were analyzed using each of the three techniques. Electron impact ionization following gas chromatography or particle beam introduction typically generates very reproducible, library-searchable mass spectra. Most of the CW breakdown compounds examined using the PBI interface did not produce a molecular ion. Despite the lack of a molecular ion, the mass spectra of the various compounds contained enough different structural information from fragment ions for the positive identification of each. The mass spectra generated using ESI are generally limited to protonated molecular ions with little or no fragmentation. For positive identification and confirmation, tandem mass spectrometry techniques quite often must be used. Many of the compounds in this study were characterized by prominent sodiated adducts along with the protonated molecular ion. Methylphosphonic acid produced protonated dimers, trimers, etc. Although the various adduct ions can be used for additional confirmation of the molecular weight of a compound, the adducts also can result in suppression of ionization of the compound and thus reduce sensitivity. Another 'soft' ionization technique that results in abundant protonated molecular ions is APCI. The mass spectra of the breakdown compounds produced using APCI were characterized generally by either a prominent protonated molecular ion or a dehydrated form of it. In addition, a number of structurally significant fragment ions were observed and their relative abundances could be adjusted by altering the APCI conditions. The data presented here indicate that each of the three techniques can be used successfully for direct liquid introduction and analysis of the non-volatile compounds produced from the degradation of CW agents. The mass spectra produced using each technique are quite different and could be utilized as additional confirmation of compound identity.

show abstract

“…The potential of ESI and collision-induced dissociation was demonstrated by Borrett and co-workers [36,37]. Positive and negative ion electrospray mass spectra were obtained from water-alcohol solutions of phosphoric acid, methylphosphonic acid, and its mono(1,2,2-trimethylpropyl) ester and bis(l-methylethyl) ester.…”

Section: Liquid Chromatographymentioning

confidence: 99%

“…Positive and negative ion electrospray mass spectra were obtained from water-alcohol solutions of phosphoric acid, methylphosphonic acid, and its mono(1,2,2-trimethylpropyl) ester and bis(l-methylethyl) ester. The first stage of mass spectrometric measurement affording molecular mass information was followed by the second stage giving characteristic fragments supporting compound identification [36]. A method using liquid chromatography-time-of-flight mass spectrometry with electrospray ionisation has been developed for the identification and determination of alkyl methylphosphonic acids.…”

Section: Liquid Chromatographymentioning

confidence: 99%

Utilisation of separation methods in the analysis of chemical warfare agents

et al. 2006

View full text Add to dashboard Cite

Chemical warfare agents and their degradation products represent a broad group of compounds with different chemical properties (polarity, volatility, thermostability, etc.). These chemicals often have to be detected and determined in complex matrices and therefore highly efficient separation techniques hyphenated to selective and sensitive detectors play an indispensable role. This review offers an overview of selected papers devoted to the title subject. It cannot be considered as a comprehensive literature compilation but should allow the reader to obtain an insight into the application of separation techniques in the important area of human protection and control of chemical weapons.

show abstract

The electrospray mass spectra of phosphoric acid, methylphosphonic acid and its alkyl esters, and their complexes with alkali and alkali earth metal ions

Cited by 34 publications

References 0 publications

Electrospray Mass Spectrometric Detection of Neutral Metal Bipyridine Complexes Using Sodium Ions and Its Application in the Analysis of a Photochemical Ligand Substitution Reaction

Electrospray Mass Spectrometric Detection of Neutral Metal Bipyridine Complexes Using Sodium Ions and Its Application in the Analysis of a Photochemical Ligand Substitution Reaction

Analysis of the degradation compounds of chemical warfare agents using liquid chromatography/mass spectrometry

Utilisation of separation methods in the analysis of chemical warfare agents

Contact Info

Product

Resources

About