The elements of success in a comprehensive state-wide program to safely reduce the rate of preterm birth

Newnham, John P.; White, Scott W.; Lee, Han‐Shin; Arrese, Catherine A.; Watts, J. C.; Pedretti, Michelle K.; Dickinson, Jan E.; Doherty, Dorota A.

doi:10.1371/journal.pone.0234033

Cited by 9 publications

(12 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The introduction of the multifaceted PTB Prevention Initiative was associated with a significant 10% reduction in the overall rate of PTB compared to the average for the previous five years at the tertiary referral hospital in the ACT. These findings were consistent with the successful results from the WA experience 2,19 . Once PTBs were separated into grouped gestational ages the greatest reductions in preterm birth were observed in the 20–23 + 6 and 28–31 + 6 gestation age groups.…”

Section: Discussionsupporting

confidence: 85%

Preventing early births in a regional tertiary maternity unit: Evaluating preterm and early term birth rates before and after implementation of the Preterm Birth Prevention Initiative in the Australian Capital Territory

Orefice

Smythe

Doherty

et al. 2021

Aust NZ J Obst Gynaeco

Self Cite

View full text Add to dashboard Cite

Background A multifaceted preterm birth (PTB) prevention initiative was launched in the Australian Capital Territory (ACT) in 2019. The aim of this initiative was to safely lower the rate of early births across the ACT and the surrounding areas in New South Wales. Modelled on the Western Australian PTB Prevention Initiative, the program included new clinical guidelines and a new PTB prevention clinic at the main tertiary hospital. Aim To evaluate the initiative and its effects on preterm and early term birth rates at the main tertiary hospital after 16 months of implementation. Materials and Methods A before and after intervention study was conducted. Rates of preterm and early term birth before (previous five years) and after 16 months of implementation of the ACT PTB Prevention Initiative were evaluated. Results At the main tertiary hospital in The Canberra Hospital, the rate of PTB was significantly reduced by 10% after 16 months of implementation of the initiative. Rates of PTB were lower than any of the preceding five years and resulted in 45 averted or delayed PTBs. The number of planned early term births with no medical indication was significantly reduced by 34.5% and resulted in 77 averted or delayed early term births. Conclusions The multifaceted PTB Prevention Initiative safely lowered the rates of early birth in the ACT context. These results highlight the importance of prioritising early birth prevention, education, research and expanding the initiative nationwide.

show abstract

Section: Discussionsupporting

confidence: 85%

Preventing early births in a regional tertiary maternity unit: Evaluating preterm and early term birth rates before and after implementation of the Preterm Birth Prevention Initiative in the Australian Capital Territory

Orefice

Smythe

Doherty

et al. 2021

Aust NZ J Obst Gynaeco

Self Cite

View full text Add to dashboard Cite

show abstract

“…Of the women who did have a TVU, 9.4% 13 found it uncomfortable and 5.7% reported concerns about a TVU in the future. The reasons for declining a TVU in the future are provided in Table 2, with the three highest‐rating reasons for potentially declining a TVU in the future in our cohort being the following: 47.7% (257) were told by their doctor not to have this type of ultrasound, 34.4% (159) did not feel comfortable with the operator and 30.7% (166) wanted to discuss it with their doctor first.…”

Section: Resultsmentioning

confidence: 99%

“…The Western Australian Prevention of Preterm Birth Initiative (Initiative) commenced in November 2014 and resulted in an initial reduction in the state preterm birth rate 13 . This preterm birth rate reduction has been maintained at the tertiary hospital, although a sustained reduction has not occurred throughout the state.…”

Section: Methodsmentioning

confidence: 99%

The perceptions of pregnant women about cervical length screening for preterm birth prevention

Pedretti

Dickinson

Doherty

2021

Aust NZ J Obst Gynaeco

Self Cite

View full text Add to dashboard Cite

Background The Western Australian Preterm Birth Prevention Initiative was officially launched in November 2014. It demonstrated an initial decrease in the preterm birth rate in Western Australia. One of the key points of this initiative is the routine ultrasound measurement of the cervical length in mid‐pregnancy. Aim The aim of this study was to evaluate the perceptions and attitudes of Western Australian women regarding transvaginal cervical length (TVCL) screening for preterm birth prevention. Materials and methods Self‐administered questionnaires were completed by pregnant women before and after their mid‐trimester obstetric ultrasound. Maternal demographical and medical data were collected in addition to opinions of TVCL screening. Results A total of 598 women participated with the maternal age range representative of the Western Australian obstetric population. There was a high rate of acceptance of TVCL imaging, with 2% of the 149 women declining a transvaginal ultrasound (TVU) offered in this study, 1.5% refusing a TVU in the past and 5.7% reporting that they would have a concern in having a TVU in the future. Women stated that they either had declined TVCL in the past (11%) or would decline in the future (30.7%) as they wanted to discuss the procedure with their clinician first, had been advised not to have a TVU by their clinician (11% in the past and 47.7% in the future) or felt uncomfortable with the operator (22% at a previous TVU and 34.4% in the future). Conclusion Pregnant women participating in this study had a high acceptance of TVCL screening for preterm birth prevention.

show abstract

“…Optimal antenatal care (ANC) is a prerequisite to alleviate pregnancy-associated complications, including reduction of the PTB risk [ 13 ]. So far predictive clinical risk models are insufficient to identify PTB risk [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Blood gene transcript signature profiling in pregnancies resulting in preterm birth: A systematic review

Brummaier

Kabeer

Chaussabel

et al. 2020

European Journal of Obstetrics & Gynecology and Reproductiv

View full text Add to dashboard Cite

Highlights Globally, 10 % of birth are preterm and these are the leading cause of under 5-year mortality and disproportionally affect low-resource settings. Gene expression profiling in maternal blood samples obtained during pregnancy has a high potential to identify pregnant women at risk of preterm birth. To detect distinct transcriptome signatures, standardized protocols in cohorts commenced early in gestation and followed prospectively are key. Gene expression profiling in maternal blood may guide targeted interventions to alleviate the risk of preterm birth.

show abstract

The elements of success in a comprehensive state-wide program to safely reduce the rate of preterm birth

Cited by 9 publications

References 18 publications

Preventing early births in a regional tertiary maternity unit: Evaluating preterm and early term birth rates before and after implementation of the Preterm Birth Prevention Initiative in the Australian Capital Territory

Preventing early births in a regional tertiary maternity unit: Evaluating preterm and early term birth rates before and after implementation of the Preterm Birth Prevention Initiative in the Australian Capital Territory

The perceptions of pregnant women about cervical length screening for preterm birth prevention

Blood gene transcript signature profiling in pregnancies resulting in preterm birth: A systematic review

Contact Info

Product

Resources

About