The emergence of a disease caused by a mosquito origin Cluster 3.2 Tembusu virus in chickens in China

Yan, Dawei; Li, Xuesong; Wang, Zhanxin; Liu, Xingpo; Xuan, Dong; Fu, Rui; Su, Xin; Xu, Biao; Teng, Quincy; Yuan, Chunxiu; Zhang, Zhifei; Liu, Qinfang; Li, Zejun

doi:10.1016/j.vetmic.2022.109500

Cited by 16 publications

(17 citation statements)

References 21 publications

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“…TMUV was reported to cause epidemics affecting ducks in China in 2010, leading to huge economic losses and attracting widespread attention (Cao et al, 2011). A wide range of avian species, including geese, chickens, house sparrows, and pigeons, was confirmed to be naturally infected by TMUV (Tang et al, 2013a(Tang et al, , 2015Chen et al, 2014;Yan et al, 2017Yan et al, , 2022Zhu et al, 2022), and infections in human have been demonstrated by serological tests or the presence of RNA (Wolfe et al, 2001;Tang et al, 2013b). Due to the lack of widespread surveillance, the virus is mostly reported in Thailand, Malaysia, and China, with few reports of TMUV in Vietnam (Hamel et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Survey of mosquito species and mosquito-borne viruses in residential areas along the Sino–Vietnam border in Yunnan Province in China

Tian

He²,

Shang³

et al. 2023

Front. Microbiol.

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Mosquitoes are capable of carrying complex pathogens, and their feeding habits on the mammalian blood can easily mediate the spread of viruses. Surveillance of mosquito-based arbovirus enables the early prevention and control of mosquito-borne arboviral diseases. The climate and geography of Yunnan Province in China are ideal for mosquitoes. Yunnan shares borders with several other countries; therefore, there exists a high risk of international transmission of mosquito-mediated infectious diseases. Previous studies have focused more on the Sino–Laos and Sino–Myanmar borders. Therefore, we focused on the neighborhoods of Malipo and Funing counties in Wenshan Prefecture, Yunnan Province, China, which are located along the Sino–Vietnam border, to investigate the species of mosquitoes and mosquito-borne viruses in the residential areas of this region. This study collected 10,800 mosquitoes from 29 species of 8 genera and grouped to isolate mosquito-borne viruses. In total, 62 isolates were isolated and classified into 11 viral categories. We demonstrated a new distribution of mosquito-borne viruses among mosquitoes in border areas, including Tembusu and Getah viruses, which can cause animal outbreaks. In addition, Dak Nong and Sarawak viruses originating from Vietnam and Malaysia, respectively, were identified for the first time in China, highlighting the complexity of mosquito-borne viruses in the Sino–Vietnam border region. The awareness of the importance of viral surveillance and prevention measures in border areas should be further encouraged to prevent future outbreaks of potentially infectious diseases.

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Section: Discussionmentioning

confidence: 99%

Survey of mosquito species and mosquito-borne viruses in residential areas along the Sino–Vietnam border in Yunnan Province in China

Tian

He²,

Shang³

et al. 2023

Front. Microbiol.

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“…The pathogen responsible for this outbreak was eventually con rmed as duck TMUV. Currently, TMUV strains have been classi ed into three clusters based on their major antigen gene E [2,3]. Cluster 1 includes TMUV strains isolated from Southeast Asia, while Cluster 2 consists of most waterfowl-origin isolates from China and Southeast Asian countries.…”

Section: Introductionmentioning

confidence: 99%

Vector Competence of Culex quinquefasciatus for Tembusu Virus and Viral Determinants for Virus Transmission by Mosquitoes

Tang,

He,

Wang

et al. 2024

Preprint

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The recent pandemic of flaviviruses all over the world has underscored the importance of studying flavivirus vector competence, as the evolutionary enhancement of mosquito transmission played a significant role in its spread. Tembusu virus is an avian-related mosquito-borane flavivirus, which is mainly epidemic in China and Southeast Asia since 2010. However, the reason for the outbreak of Tembusu virus in 2010 remains unclear, and it is unknown whether changes in vector transmission played an essential role in this process. To address these questions, we conducted a study using Culex quinquefasciatus as a model for Tembusu virus infection, employing both oral infection and microinjection methods. Our findings confirmed that both vertical and horizontal transmission collectively contribute to the cycle of Tembusu virus within the mosquito population, with persistent infection observed. Importantly, our data revealed that the prototypical Tembusu virus MM_1775 strain exhibited significantly higher infectivity and transmission rates in mosquitoes compared to a duck Tembusu virus (CQW1 strain). Furthermore, we identified that the viral E protein and 3' untranslated region are key elements responsible for these differences. In conclusion, our study sheds light on the mosquito transmission of Tembusu virus and provides valuable insights into the factors influencing its infectivity and transmission rates. These findings contribute to a better understanding of Tembusu virus epidemiology and can potentially aid in the development of strategies to control its spread.

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“…However, our current understanding of TMUV pathogenicity in chickens remains limited. Although sporadic cases of TMUV-induced egg drop syndrome in laying hens have been reported in China ( Yan et al, 2022 ; Yu et al, 2022 ), widespread TMUV infections in chicken flocks have not been documented. Given the significant chicken farming industry in Taiwan and the potential risk of virus spread, it is crucial to investigate the infectivity and pathogenicity of local TMUV strains in chickens.…”

Section: Introductionmentioning

confidence: 99%

A novel goose-origin Tembusu virus exhibits pathogenicity in day-old chicks with evidence of direct contact transmission

Liu,

Chen,

Twu

et al. 2024

Poultry Science

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The emergence of a disease caused by a mosquito origin Cluster 3.2 Tembusu virus in chickens in China

Cited by 16 publications

References 21 publications

Survey of mosquito species and mosquito-borne viruses in residential areas along the Sino–Vietnam border in Yunnan Province in China

Survey of mosquito species and mosquito-borne viruses in residential areas along the Sino–Vietnam border in Yunnan Province in China

Vector Competence of Culex quinquefasciatus for Tembusu Virus and Viral Determinants for Virus Transmission by Mosquitoes

A novel goose-origin Tembusu virus exhibits pathogenicity in day-old chicks with evidence of direct contact transmission

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