The emergence of extended-spectrum β-lactamase (ESBL)-producing Salmonella London isolates from human patients, retail meats and chickens in southern China and the evaluation of the potential risk factors of Salmonella London

Xu, Ziheng; Wang, Min; Wang, Can; Zhou, Chenyu; JingZhen, Liang; Gu, Guimin; Wang, Mingliu; Wei, Ping

doi:10.1016/j.foodcont.2021.108187

Cited by 9 publications

(6 citation statements)

References 23 publications

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“…Salmonella is an important foodborne pathogen that has a nearly ubiquitous distribution among humans, animals, and the open environment. According to the WHO, there over 90 million people are infected by Salmonella annually, and 150,000 people die from Salmonella infection [ 1 ]. Over 2600 Salmonella serotypes have been identified and can be referred to as typhoidal or non-typhoidal (NTS); the latter are present in different animal reservoirs and are responsible for self-limiting gastrointestinal syndromes [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Global Spread and Molecular Characterization of CTX-M-Producing Salmonella Typhimurium Isolates

Guo

Zhao

2021

Antibiotics

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This study aimed to determine the global prevalence and molecular characterization of CTX-M-producing Salmonella Typhimurium isolates. A total of 330 (15.2%, 330/21779) blaCTX-M-positive S. Typhimurium were obtained from the public databases in July 2021. Thirteen variants were found in the 330 members of the blaCTX-M group, and blaCTX-M-9 (26.4%, 88/330) was the most prevalent. The majority of blaCTX-M-positive S. Typhimurium were obtained from humans (59.7%, 197/330) and animals (31.5%, 104/330). The number of blaCTX-M-positive S. Typhimurium increased annually (p < 0.0001). These isolates were primarily found from China, the United Kingdom, Australia, the USA, and Germany. In addition, these isolates possessed 14 distinct sequence types (ST), and three predominated: ST34 (42.7%, 141/330), ST19 (37.0%, 122/330), and ST313 (10.3%, 34/330). The majority of ST34 S. Typhimurium isolates were distributed in China and mainly from swine. However, the majority of ST19 were distributed in the United Kingdom and Australia. Analysis of contigs showed that the major type of blaCTX-M-carrying plasmid was identified as IncI plasmid (52.9%, 27/51) and IncHI2 plasmid (17.6%, 9/51) in 51 blaCTX-M-positive S. Typhimurium isolates. In addition, WGS analysis further revealed that blaCTX-M co-existed with nine antibiotic-resistant genes with a detection rate over 50%, conferring resistance to five classes of antimicrobials. The 154 virulence genes were detected among these isolates, of which 107 virulence genes were highly common. This study revealed that China has been severely contaminated by blaCTX-M-positive S. Typhimurium isolates, these isolates possessed numerous ARGs and virulence genes, and highlighted that continued vigilance for blaCTX-M-positive S. Typhimurium in animals and humans is urgently needed.

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Section: Introductionmentioning

confidence: 99%

Global Spread and Molecular Characterization of CTX-M-Producing Salmonella Typhimurium Isolates

Guo

Zhao

2021

Antibiotics

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“…The emergence of antimicrobial resistance of Salmonella spp. against βlactam antimicrobials has become a significant challenge for human medicine (Sabry et al 2020), especially against Aztreonam (Xu et al 2021). In several studies, Salmonella spp.…”

Section: Discussionmentioning

confidence: 99%

Multidrug-resistant Salmonella species from chicken meat sold at Surabaya Traditional Markets, Indonesia

et al. 2022

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Abstract. Fanissa F, Effendi MH, Tyasningsih W, Ugbo EN. 2022. Multidrug-resistant Salmonella species from chicken meat sold at Surabaya Traditional Markets, Indonesia. Biodiversitas 23: 2823-2829. Salmonella species is one of the major infectious pathogens associated with poultry birds, which also has an impact on public health. Antimicrobials are used as growth promoters or treatment of diseases thus; this encourages the persistent spread of antimicrobial resistance (AMR). This study aimed to identify multidrug-resistant Salmonella species from traditional chicken meat sold at Surabaya markets. A total of 150 chicken meat swab samples were collected from five different traditional markets and identified using microbiological standard methods. The Kirby-Bauer disk diffusion method identified multidrug-resistant Salmonella species on five different antibiotics discs. A low prevalence of Salmonella species was detected with a frequency of 11.3% (17/150). Some of the Salmonella isolates showed strong resistance to trimethoprim-sulfamethoxazole, tetracycline, aztreonam, and chloramphenicol. Five (29.4%) out of seventeen were multidrug-resistant Salmonella species. The presence of multidrug-resistant Salmonella species in these traditional markets is worrisome, since, it can lead to an outbreak of Salmonellosis as a result of the consumption of contaminated chicken meat. Therefore, the detection of multidrug-resistant Salmonella species is significant in understanding their prevalence and development of AMR. More strong awareness education and monitoring programs are recommended to mitigate the persistent spread of antimicrobial resistance.

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“…In recent years, the number of cases with Salmonella resistance to clinically significant antimicrobials, such as fluoroquinolones and third-generation cephalosporins, has increased [ 15 , 16 ]. A serious problem of recent decades, not only for human medicine [ 17 ] but also for animals [ 18 ], is the appearance of strains producing extended-spectrum beta-lactamases that are capable of hydrolyzing beta-lactam antibiotics.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and resistance to antibacterial agents in Salmonella enterica strains isolated from poultry products in Northern Kazakhstan

et al. 2023

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Background and Aim: Salmonella is one of the main causative agents of foodborne infections. The source of the pathogen, in most cases, is poultry products. The intensification of poultry farming and the constant and uncontrolled use of antimicrobials has led to an increase in the level of antibiotic resistance, especially in developing countries. This study aimed to determine the level of sensitivity to antimicrobial agents in Salmonella enterica strains isolated from poultry products in Northern Kazakhstan, as well as to determine the genetic mechanisms of resistance and the presence of integrons. Materials and Methods: In total, 398 samples of poultry products sold in Northern Kazakhstan were selected. Salmonella strains were isolated from product samples using microbiological methods. Salmonella was identified based on morphological, biochemical, and serological methods, as well as polymerase chain reaction (PCR). Sensitivity testing for antimicrobial agents was performed using the disk diffusion method. The detection of resistance genes was performed using PCR and gel electrophoresis. Results: Out of 398 samples of poultry products, a total of 46 Salmonella isolates were obtained. Most of the isolates belong to the serovar Salmonella Enteritidis (80.4%). The assessment of sensitivity to antibacterial agents showed that Salmonella was mainly resistant to nalidixic acid (63%), furadonin (60.9%), ofloxacin (45.6%), and tetracycline (39.1%). In 64.3% of cases, Salmonella was resistant to three or more groups of antibacterial agents. Resistance genes such as tetA, tetB, blaTEM, aadA, sul3, and catII, as well as integrons of two classes (teg1 and teg2), were identified. Conclusion: Poultry products contain antimicrobial-resistant strains of Salmonella, as well as genes encoding resistance mechanisms. The results emphasize the need for constant monitoring of not only pathogenic microorganisms but also their sensitivity to antimicrobial agents. The potential threat to human health requires a unified approach to the problem of antibiotic resistance from representatives of both public health and the agroindustrial complex. Keywords: antibiotic resistance, food safety, poultry, resistance genes, Salmonella.

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The emergence of extended-spectrum β-lactamase (ESBL)-producing Salmonella London isolates from human patients, retail meats and chickens in southern China and the evaluation of the potential risk factors of Salmonella London

Cited by 9 publications

References 23 publications

Global Spread and Molecular Characterization of CTX-M-Producing Salmonella Typhimurium Isolates

Global Spread and Molecular Characterization of CTX-M-Producing Salmonella Typhimurium Isolates

Multidrug-resistant Salmonella species from chicken meat sold at Surabaya Traditional Markets, Indonesia

Prevalence and resistance to antibacterial agents in Salmonella enterica strains isolated from poultry products in Northern Kazakhstan

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