The emergence of insulin resistance following a chronic high-fat diet regimen coincides with an increase in the reinforcing effects of nicotine in a sex-dependent manner

Cruz, Bryan; Ortegon, Sebastian; Giner, Priscilla; Matos-Ocasio, Felix; Rodríguez-Crespo, Andrea; Uribe, Kevin P.; Galindo, Kayla I; Serafine, Katherine M.; Nazarian, Arbi; O’Dell, Laura E.

doi:10.1016/j.neuropharm.2021.108787

Cited by 9 publications

(9 citation statements)

References 37 publications

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“…In contrast, both male and female mice conditioned with HFD in one conditioning chamber and RCD in the opposite chamber (treated group) displayed a robust CPP response following the single conditioning with oxycodone, when paired with the HFD-paired chamber (PCh). Our results are consistent with previous reports [28][29][30] suggesting that prior exposure to HFD enhances the rewarding action of addictive drugs, in this case, oxycodone. However, given that it is generally thought that palatable food is rewarding (for a review, see [31]) and that mice already showed CPP following LAC with HFD, it is unclear whether the CPP response following oxycodone is potentiation of oxycodone reward or oxycodone conditioning increased the expression of the CPP induced by HFD.…”

Section: Discussionsupporting

confidence: 93%

<strong>The Role of Mu Opioid Receptors in High Fat Diet-induced Reward and Potentiation of the Rewarding Effect of Oxycodone</strong>

Iqbal¹,

Hamid²,

Ahmad³

et al. 2023

Preprint

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Excessive high fat diet (HFD) consumption can induce food addiction which is believed to involve the communication between the hypothalamus and mesolimbic dopaminergic neurons, originating in the ventral tegmental area (VTA) and projecting to the nucleus accumbens (NAc). These brain regions are densely populated with opioid receptors, raising the possibility that these receptors, and particularly mu opioid receptors (MORs), are involved in mediating reward induced by palatable foods. This study sought to investigate the involvement of MORs in high fat diet (HFD)-induced reward and if there is any difference between male and female subjects in this response. We also assessed if exposure to HFD would potentiate the rewarding action of oxycodone, a relatively selective MOR agonist. The place conditioning paradigm was used to determine if conditioning for a short time (STC, 2 h) or long time (LTC, 16 h) with HFD induces reward or alters the rewarding action of oxycodone. Male and female C57BL/6J mice as well as MOR knockout and wildtype mice of both sexes were tested for basal place preference on day 1 and then conditioned with HFD in one chamber and regular chow diet (RCD) in another chamber and tested for place preference again after three sets of STC and again after a set of LTC. Each set consisted of two conditioning with RCD and two conditioning with HFD. Controls were conditioned with RCD in both conditioning chambers. Following the last place preference test, mice were treated with oxycodone and conditioned in the HFD-paired chamber and saline in the RCD-paired chamber for one hour once a day to explore the possibility if the HFD could alter oxycodone reward. The result showed that HFD induced conditioned place preference (CPP) in both male and female subjects following the LTC. This response was further potentiated after oxycodone conditioning. The latter response was mediated via MORs, as it was blunted in MOR knockout mice. However, HFD-induced CPP was observed following LTC in only female MOR knockout mice, suggesting for sexual dimorphism in this response.

show abstract

Section: Discussionsupporting

confidence: 93%

<strong>The Role of Mu Opioid Receptors in High Fat Diet-induced Reward and Potentiation of the Rewarding Effect of Oxycodone</strong>

Iqbal¹,

Hamid²,

Ahmad³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…In contrast, both male and female mice conditioned with HFD in one conditioning chamber and RCD in the opposite chamber (HFD group) displayed a robust CPP response following the single conditioning with oxycodone when paired with the HFD-paired chamber (PCh). Our results are consistent with previous reports [ 42 , 43 , 44 ] suggesting that prior exposure to HFD enhances the rewarding action of addictive drugs; in this case, oxycodone. However, given that it is generally thought that palatable food is rewarding (for a review, see [ 45 ]) and that mice already showed CPP following LTC with HFD, it is unclear whether conditioning with HFD potentiated the oxycodone reward or the enhanced reward following oxycodone was a result of the CPP induced by HFD.…”

Section: Discussionsupporting

confidence: 93%

The Role of Mu Opioid Receptors in High Fat Diet-Induced Reward and Potentiation of the Rewarding Effect of Oxycodone

Iqbal

Hamid

Ahmad

et al. 2023

Life

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Excessive high fat diet (HFD) consumption can induce food addiction, which is believed to involve the communication between the hypothalamus and mesolimbic dopaminergic neurons, originating in the ventral tegmental area (VTA) and projecting to the nucleus accumbens (NAc). These brain areas are densely populated with opioid receptors, raising the possibility that these receptors, and particularly mu opioid receptors (MORs), are involved in rewards elicited by palatable food. This study sought to investigate the involvement of MORs in HFD-induced reward and if there is any difference between male and female subjects in this response. We also assessed if exposure to HFD would alter the rewarding action of oxycodone, a relatively selective MOR agonist. The place conditioning paradigm was used as an animal model of reward to determine if short-time (STC, 2 h) or long-time (LTC, 16 h) conditioning with HFD induces reward or alters the rewarding action of oxycodone. Male and female C57BL/6J mice as well as MOR knockout and their wildtype littermates of both sexes were tested for basal place preference on day 1 and then conditioned with an HFD in one chamber and a regular chow diet (RCD) in another chamber for 2 h on alternate days. Three sets of STC were used, followed by a set of LTC. Each set of conditioning consisted of two conditioning with RCD and two conditioning with HFD. Mice were tested for place preference after each set of STC and again after LTC. Controls were conditioned with RCD in both conditioning chambers. Following the last place preference test, mice were treated with oxycodone and conditioned in the HFD-paired chamber and with saline in the RCD-paired chamber for one hour once a day to explore the possibility if the HFD could alter oxycodone reward. The result showed that HFD induced conditioned place preference (CPP) in male but not female subjects. However, oxycodone conditioning elicited reward in both male and female mice of the HFD group but not the control group, showing that prior conditioning with HFD potentiated the rewarding action of oxycodone. The latter response was mediated via MORs, as it was blunted in MOR knockout mice. Similarly, HFD-induced CPP was blunted in male MOR knockout mice, suggesting sexual dimorphism in this response.

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“…Nevertheless, more doses of nicotine should be tested to see how the LHb/VTA dynamics would change. Finaly, our experiments were performed in male rats but a growing number of studies reports genderspecific effects of nicotine that need to be addressed in future studies (Chellian et al, 2021;Cruz et al, 2021;O'Dell & Torres, 2014).…”

Section: Discussionmentioning

confidence: 99%

Nicotine modulation of the lateral habenula/ventral tegmental area circuit dynamics: An electrophysiological study in rats

et al. 2022

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The emergence of insulin resistance following a chronic high-fat diet regimen coincides with an increase in the reinforcing effects of nicotine in a sex-dependent manner

Cited by 9 publications

References 37 publications

<strong>The Role of Mu Opioid Receptors in High Fat Diet-induced Reward and Potentiation of the Rewarding Effect of Oxycodone</strong>

<strong>The Role of Mu Opioid Receptors in High Fat Diet-induced Reward and Potentiation of the Rewarding Effect of Oxycodone</strong>

The Role of Mu Opioid Receptors in High Fat Diet-Induced Reward and Potentiation of the Rewarding Effect of Oxycodone

Nicotine modulation of the lateral habenula/ventral tegmental area circuit dynamics: An electrophysiological study in rats

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